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The map label for this gene is lon [H]

Identifier: 50084309

GI number: 50084309

Start: 1101710

End: 1104136

Strand: Reverse

Name: lon [H]

Synonym: ACIAD1115

Alternate gene names: 50084309

Gene position: 1104136-1101710 (Counterclockwise)

Preceding gene: 50084310

Following gene: 50084308

Centisome position: 30.68

GC content: 42.6

Gene sequence:

>2427_bases
ATGTCTGAAAATATTATGAAAGTAGAAACCTTAGAGCCTCAGGTTCAAAGTGTATTACCGCTCTTAGCGTTACGTGATGT
TGTGGTGTATCCACACATGCAAATCGCGCTATTTGTAGGTCGTGAAAAATCGATCAATGCAGTTGATGTGGCTCGTAACA
GTGACAATTTAGTATTTGTAGTTGCACAAAAGGATTCTCTCACCGAAGAAATTGATCACGACAACCTTTATCAATACGGT
ACTGTCGCGAAGATTGTGCAAGTTGTGAATCACGAAAATGATGAAAACTGTATCAAAGTTTTGATCGAAGGCTTATATCG
ATCAAAACTCACAAAAATTATTGATGAAGACAGTTATTTGACTGCCGAACATCAACTAAGCCCAATGACTGTAACAATCG
ATCAAGAGACGCAAGAGACTCGTCTTCAAGAATTACGCAATTTATTTAGCCAATATGCTGAAGCAAAATTGCGTAATGCG
CGTGAACTGATTGCTGCGGCAAATAAAATTGAAGATTTGCTACAACTGATGTTCTTTGTCGCAACACGTGTTCCGCTCAA
CATTGATGTGAAACAAAAATTTCTTGAACATAACGAGTTTGAAGCACACTTACAAGAGTTGATGAGCTATCTGGTTCAGC
AATCTGCTGAGCAACAGATAGAACAAACACTGCATGATAATGTAAAACGCCAAATGGAAAAGAATCAACGTGAATACTTT
CTCAATGAAAAAATGAAAGTGATTCAGCGTGAACTTTCCGACATGAATGGCGGTGCTGAAGACGATGTTGCTGAAATTGA
AAAACGTCTTGTTGAAGCAGATTTGCCTGAGCATGTGCGTAAAAAAGCTGAAGCCGAGTTTCGTAAGTTAAAAGCAATGC
AGCCTGCTTCAAGTGAAGCGGCCGTGGTGCGCAATTACCTTGAAGTGATTCTAGATACACCTTGGAATACTGCAAGCAAG
GTCAGTATTAACCTGAAAAAAGCACAGGAAATTCTGGATGCAGACCATTATGGCCTTGATGATGTCAAAGACCGTATTGT
CGAATATCTTGCTGTGCAATCGCGTGTGAAAAAACTTCGCGGACCAATCTTATGCTTGGTCGGACCTCCAGGTGTGGGTA
AAACCTCACTGGGTGAATCGATTGCCAAAGCAACAGGTCGTGAGTTTGTACGCATGGCTTTAGGTGGTGTGCGTGACGAA
GCTGAAATTCGTGGTCACCGTCGTACTTATATTGGTGCAATGCCAGGTAAAATCGTACAGTCTTTAACCAAAGTGGGCGT
AAAAAACCCATTGTTCTTGCTCGATGAAATCGACAAGATGGCGCAAGACTATCGAGGTGATCCTGCATCTGCAATGCTAG
AAGTATTGGATCCATCGCAAAACAACAAGTTCAACGATCATTATCTTGATCTAGACCTTGATCTGTCTGAAGTGATGTTT
ATCTGTACTGCAAACAGCATGAATATTCCTGAAGCGTTGTTAGACCGTATGGAAGTAATTCGTCTTCCTGGCTACACCGA
AGAAGAGAAAGTTAAGATTGCTGATCGCTACTTGGTTCCAAAAGCAATTAAGGACAATGGTTTGCGTAGCAGTGAATTGA
CTGTTCATGAAGAAGCGATTCGTGACATTGTACGACGCTACACACGTGAAGCAGGTGTGCGTAGCCTTGAGCGTGAAGTG
TCTAAAATTGCACGTAAGGTAGTGAAAGAAGCGGTAAGCAAGAAGAGTAAAAATCTGCATATCGATGTGACTCAAGAAAC
GCTTCCTGAGTATCTTGGTCCACACAAGTTTGACTTTGGTATTGCAGAGGAAGAAGCTCAGGTTGGTCGTGTAAACGGCT
TGGCATGGACATCAGTCGGTGGCGAGTTGCTCACTATTGAAGTGGCAGCGGTGAAAGGTAAAGGTAAATTCATTACGACT
GGCTCTTTGGGCGATGTCATGAAGGAATCGATTACTGCGGCCATGACGGTAGTGAGAACACGTGCGGATGAATTGGGTAT
TGAAGCTTCACGCTTTGAAGAAACCGATGTTCACGTGCATTTGCCTGAAGGCGCTACACCAAAAGACGGTCCGTCTGCTG
GTTTGGCACTGACTACCGCACTTGTATCTGCATTTACGGGTATTCCGATTCGTGCTGATATTGCAATGACAGGTGAAACC
TCTTTACGTGGTAATGCACTACGTATTGGTGGTTTGAAAGAAAAGCTATTGGCTGCACACCGTGGTGGAATCAAACTTGT
CTTTATCCCGCAAGATAACGTGCGTGATTTGGCTGAAATACCAGACAATGTTAAAGAGGGTTTAGAAATCAAAGCAGTGA
AAAGCATTGATGAAATCTTACCTTTAGCTTTGACAGAACAGCCTAAACCATTGGCCAAAGCACCAATTGTTAAGCCTGTA
GAAGAGTCAAAAGCGGCACGTCATTGA

Upstream 100 bases:

>100_bases
CATTTTTTTGACATTTTCTATTGTCATGCCCTTGTAATTTTTAAAATACCCATCACTATAAAAAACATGGCAACCTCGTT
GTCACTCATTAGGAGTGCCC

Downstream 100 bases:

>100_bases
TGTAGTAAAAATCCAATAAAAAAGAGAGCTTCGGCTCTCTTTTTTACATTTATAAGGTTGAAAAATGATCAATTATCTCC
ATAATAATATTATATGCTCA

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MSENIMKVETLEPQVQSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFVVAQKDSLTEEIDHDNLYQYG
TVAKIVQVVNHENDENCIKVLIEGLYRSKLTKIIDEDSYLTAEHQLSPMTVTIDQETQETRLQELRNLFSQYAEAKLRNA
RELIAAANKIEDLLQLMFFVATRVPLNIDVKQKFLEHNEFEAHLQELMSYLVQQSAEQQIEQTLHDNVKRQMEKNQREYF
LNEKMKVIQRELSDMNGGAEDDVAEIEKRLVEADLPEHVRKKAEAEFRKLKAMQPASSEAAVVRNYLEVILDTPWNTASK
VSINLKKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIAKATGREFVRMALGGVRDE
AEIRGHRRTYIGAMPGKIVQSLTKVGVKNPLFLLDEIDKMAQDYRGDPASAMLEVLDPSQNNKFNDHYLDLDLDLSEVMF
ICTANSMNIPEALLDRMEVIRLPGYTEEEKVKIADRYLVPKAIKDNGLRSSELTVHEEAIRDIVRRYTREAGVRSLEREV
SKIARKVVKEAVSKKSKNLHIDVTQETLPEYLGPHKFDFGIAEEEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITT
GSLGDVMKESITAAMTVVRTRADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIPIRADIAMTGET
SLRGNALRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEILPLALTEQPKPLAKAPIVKPV
EESKAARH

Sequences:

>Translated_808_residues
MSENIMKVETLEPQVQSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFVVAQKDSLTEEIDHDNLYQYG
TVAKIVQVVNHENDENCIKVLIEGLYRSKLTKIIDEDSYLTAEHQLSPMTVTIDQETQETRLQELRNLFSQYAEAKLRNA
RELIAAANKIEDLLQLMFFVATRVPLNIDVKQKFLEHNEFEAHLQELMSYLVQQSAEQQIEQTLHDNVKRQMEKNQREYF
LNEKMKVIQRELSDMNGGAEDDVAEIEKRLVEADLPEHVRKKAEAEFRKLKAMQPASSEAAVVRNYLEVILDTPWNTASK
VSINLKKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIAKATGREFVRMALGGVRDE
AEIRGHRRTYIGAMPGKIVQSLTKVGVKNPLFLLDEIDKMAQDYRGDPASAMLEVLDPSQNNKFNDHYLDLDLDLSEVMF
ICTANSMNIPEALLDRMEVIRLPGYTEEEKVKIADRYLVPKAIKDNGLRSSELTVHEEAIRDIVRRYTREAGVRSLEREV
SKIARKVVKEAVSKKSKNLHIDVTQETLPEYLGPHKFDFGIAEEEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITT
GSLGDVMKESITAAMTVVRTRADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIPIRADIAMTGET
SLRGNALRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEILPLALTEQPKPLAKAPIVKPV
EESKAARH
>Mature_807_residues
SENIMKVETLEPQVQSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFVVAQKDSLTEEIDHDNLYQYGT
VAKIVQVVNHENDENCIKVLIEGLYRSKLTKIIDEDSYLTAEHQLSPMTVTIDQETQETRLQELRNLFSQYAEAKLRNAR
ELIAAANKIEDLLQLMFFVATRVPLNIDVKQKFLEHNEFEAHLQELMSYLVQQSAEQQIEQTLHDNVKRQMEKNQREYFL
NEKMKVIQRELSDMNGGAEDDVAEIEKRLVEADLPEHVRKKAEAEFRKLKAMQPASSEAAVVRNYLEVILDTPWNTASKV
SINLKKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLRGPILCLVGPPGVGKTSLGESIAKATGREFVRMALGGVRDEA
EIRGHRRTYIGAMPGKIVQSLTKVGVKNPLFLLDEIDKMAQDYRGDPASAMLEVLDPSQNNKFNDHYLDLDLDLSEVMFI
CTANSMNIPEALLDRMEVIRLPGYTEEEKVKIADRYLVPKAIKDNGLRSSELTVHEEAIRDIVRRYTREAGVRSLEREVS
KIARKVVKEAVSKKSKNLHIDVTQETLPEYLGPHKFDFGIAEEEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITTG
SLGDVMKESITAAMTVVRTRADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIPIRADIAMTGETS
LRGNALRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEILPLALTEQPKPLAKAPIVKPVE
ESKAARH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=837, Percent_Identity=37.037037037037, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=616, Percent_Identity=42.3701298701299, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=56.9948186528497, Blast_Score=863, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=666, Percent_Identity=39.4894894894895, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17556486, Length=799, Percent_Identity=32.1652065081352, Blast_Score=424, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=40.8888888888889, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=608, Percent_Identity=43.2565789473684, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666867, Length=608, Percent_Identity=43.2565789473684, Blast_Score=512, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90239; Mature: 90108

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENIMKVETLEPQVQSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFV
CCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCEEEE
VAQKDSLTEEIDHDNLYQYGTVAKIVQVVNHENDENCIKVLIEGLYRSKLTKIIDEDSYL
EECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
TAEHQLSPMTVTIDQETQETRLQELRNLFSQYAEAKLRNARELIAAANKIEDLLQLMFFV
ECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRVPLNIDVKQKFLEHNEFEAHLQELMSYLVQQSAEQQIEQTLHDNVKRQMEKNQREYF
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEKMKVIQRELSDMNGGAEDDVAEIEKRLVEADLPEHVRKKAEAEFRKLKAMQPASSEA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHH
AVVRNYLEVILDTPWNTASKVSINLKKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLR
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPILCLVGPPGVGKTSLGESIAKATGREFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQ
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHH
SLTKVGVKNPLFLLDEIDKMAQDYRGDPASAMLEVLDPSQNNKFNDHYLDLDLDLSEVMF
HHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEEE
ICTANSMNIPEALLDRMEVIRLPGYTEEEKVKIADRYLVPKAIKDNGLRSSELTVHEEAI
EEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHH
RDIVRRYTREAGVRSLEREVSKIARKVVKEAVSKKSKNLHIDVTQETLPEYLGPHKFDFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCCC
IAEEEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITTGSLGDVMKESITAAMTVVRT
CCHHHHHHCCCCCEEEECCCCEEEEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHH
RADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIPIRADIAMTGET
HHHHHCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
SLRGNALRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEIL
CCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHCCCEEHHHHHHHHHH
PLALTEQPKPLAKAPIVKPVEESKAARH
HHHHCCCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
SENIMKVETLEPQVQSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFV
CCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCEEEE
VAQKDSLTEEIDHDNLYQYGTVAKIVQVVNHENDENCIKVLIEGLYRSKLTKIIDEDSYL
EECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
TAEHQLSPMTVTIDQETQETRLQELRNLFSQYAEAKLRNARELIAAANKIEDLLQLMFFV
ECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRVPLNIDVKQKFLEHNEFEAHLQELMSYLVQQSAEQQIEQTLHDNVKRQMEKNQREYF
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEKMKVIQRELSDMNGGAEDDVAEIEKRLVEADLPEHVRKKAEAEFRKLKAMQPASSEA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHH
AVVRNYLEVILDTPWNTASKVSINLKKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLR
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GPILCLVGPPGVGKTSLGESIAKATGREFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQ
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHH
SLTKVGVKNPLFLLDEIDKMAQDYRGDPASAMLEVLDPSQNNKFNDHYLDLDLDLSEVMF
HHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHEEE
ICTANSMNIPEALLDRMEVIRLPGYTEEEKVKIADRYLVPKAIKDNGLRSSELTVHEEAI
EEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHH
RDIVRRYTREAGVRSLEREVSKIARKVVKEAVSKKSKNLHIDVTQETLPEYLGPHKFDFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCCC
IAEEEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITTGSLGDVMKESITAAMTVVRT
CCHHHHHHCCCCCEEEECCCCEEEEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHH
RADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIPIRADIAMTGET
HHHHHCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
SLRGNALRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEIL
CCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHCCCEEHHHHHHHHHH
PLALTEQPKPLAKAPIVKPVEESKAARH
HHHHCCCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA