Click here to switch to the map view.

The map label for this gene is ureC

Identifier: 50084288

GI number: 50084288

Start: 1084558

End: 1086258

Strand: Direct

Name: ureC

Synonym: ACIAD1091

Alternate gene names: 50084288

Gene position: 1084558-1086258 (Clockwise)

Preceding gene: 50084287

Following gene: 50084289

Centisome position: 30.14

GC content: 45.21

Gene sequence:

>1701_bases
ATGAAAATGTCGCGTCGTGCATATGCTGAAATGTTTGGGCCTACGGTGGGGGATCGTGTTCGTTTAGCCGATACAGAACT
ATTTATTGAAGTTGAACAAGACCTCACGACCTATGGAGAAGAAGTCAAGTTTGGCGGTGGGAAGGTGATTCGTGATGGTA
TGGGCCAATCGCAATTACTTGCAGATGAAGTTGCCGATACCGTGATTACCAATGCATTGATTGTTGATTGGTGGGGAATC
GTCAAAGCCGATGTCGGCCTTAAAAATGGTCGCATCTGGAAAATTGGCAAAGCAGGGAATCCTGATATTCAGCCAGATAT
TACCATTCCATTGGGTGCAGCGACGGAAGTCATTGCAGGTGAGGGGCAGATACTCACTGCTGGCGGGATTGATACGCATA
TTCACTGGATTTGTCCACAGCAAGTTGAAACTGCACTGATGTCGGGCGTAACGACGATGGTCGGTGGTGGTACTGGCCCT
GCAGCAGGGACTTCTGCAACGACAGTCACACCAGGTCCCTGGCACATTGGCACCATGTTACAAGCAATTGATGATTTGCC
GATGAACATTGGATTATTAGGTAAAGGTAACTTAAGTTTGCCTGATCCAATTCGTGAGCAGATCAAAGCAGGTGTAGTGG
GGCTCAAATTGCATGAAGACTGGGGTTCAACCCCAGCAGCAATTGATAACTGCTTAAGTGTTGCAGATGAGTTTGATGTA
CAGGTGGCAATTCATACCGATACTCTCAACGAAAGTGGTTTTTTAGAAGAAACCTTGGCGGCATTTAAAAATCGTACCAT
TCATACGTATCACACCGAAGGTGCGGGCGGTGGACATGCACCTGATATTTTAAAGGCCATTGGTCAAGCCAATGTCTTAC
CATCTTCAACGAATCCGACACGTCCTTATACCATTAACACCATTGATGAACATCTGGATATGTTGATGGTGTGTCATCAT
CTTGATCCAGCGATTGCAGAAGATGTGGCTTTTGCAGAAAGTCGAATTCGCCGTGAAACCATTGCTGCGGAAGATATTTT
GCAAGATTTAGGCGCAATTGCGATGATGTCCTCAGATTCACAAGCAATGGGGCGTGTGGGTGAGGTGATTATTCGTACAT
GGCAAACTGCACATAAAATGAAAGTCCAGCGCGGTGCATTGCAGGGCGATGAGACAAGCCATGATAACAGCCGAGTCAAA
CGTTATATTGCCAAGTACACCATCAATCCTGCAATTACGCATGGTTTAAGTCATGAAATTGGTTCGGTGGAAGAAGGAAA
ACTCGCAGATTTGGTATTGTGGAAACCTGCTTTCTTTGGGGTTAAACCTTCTATGATTATCAAAGGCGGTATGATTGCGG
CTGCGCCAATGGGGGATATCAATGCCTCAATTCCAACGCCACAACCTGTACATTATCGTCCAATGTTTGGTGCTTACCCA
CGTGGTGTGCATAACACCTGCATTACCTTTTTGTCACAAGCCGCAATTGATGATGGTGTAGCAGAAAAGCTAAAACTGAA
AAAGCTGATCAGTCCTTGTAAAAATACTCGCCAGATCACTAAGGCTGATATGAAACATAATACCTATTGCCCAGTGATGG
ATGTTCATCCAGAAACTTATGAAGTACGTGCAGATGGTGAGTTGTTGACTTGTGAACCTGCGGATGTATTACCAATGGCG
CAACGTTATTTCTTGTTTTAA

Upstream 100 bases:

>100_bases
GTTGGTTGCTTTGTCAGGTAAACGTCAAGTTTACGGTTTCGCTGGGCGTGTCATGGGCGCATTGGATTAAAAATTAATAC
AGATTAGAAGGTCTTTTATT

Downstream 100 bases:

>100_bases
GGCTAAGATAAGACGTGATTTATTTAATCCGGCATGCGCAAAGTATGGCTAATGTAAATGCAAGATGTACTTCGCATGCC
AGTATTGCATTGACTGAACA

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKMSRRAYAEMFGPTVGDRVRLADTELFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGI
VKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGVTTMVGGGTGP
AAGTSATTVTPGPWHIGTMLQAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVVGLKLHEDWGSTPAAIDNCLSVADEFDV
QVAIHTDTLNESGFLEETLAAFKNRTIHTYHTEGAGGGHAPDILKAIGQANVLPSSTNPTRPYTINTIDEHLDMLMVCHH
LDPAIAEDVAFAESRIRRETIAAEDILQDLGAIAMMSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALQGDETSHDNSRVK
RYIAKYTINPAITHGLSHEIGSVEEGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
RGVHNTCITFLSQAAIDDGVAEKLKLKKLISPCKNTRQITKADMKHNTYCPVMDVHPETYEVRADGELLTCEPADVLPMA
QRYFLF

Sequences:

>Translated_566_residues
MKMSRRAYAEMFGPTVGDRVRLADTELFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGI
VKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGVTTMVGGGTGP
AAGTSATTVTPGPWHIGTMLQAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVVGLKLHEDWGSTPAAIDNCLSVADEFDV
QVAIHTDTLNESGFLEETLAAFKNRTIHTYHTEGAGGGHAPDILKAIGQANVLPSSTNPTRPYTINTIDEHLDMLMVCHH
LDPAIAEDVAFAESRIRRETIAAEDILQDLGAIAMMSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALQGDETSHDNSRVK
RYIAKYTINPAITHGLSHEIGSVEEGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
RGVHNTCITFLSQAAIDDGVAEKLKLKKLISPCKNTRQITKADMKHNTYCPVMDVHPETYEVRADGELLTCEPADVLPMA
QRYFLF
>Mature_566_residues
MKMSRRAYAEMFGPTVGDRVRLADTELFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGI
VKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGVTTMVGGGTGP
AAGTSATTVTPGPWHIGTMLQAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVVGLKLHEDWGSTPAAIDNCLSVADEFDV
QVAIHTDTLNESGFLEETLAAFKNRTIHTYHTEGAGGGHAPDILKAIGQANVLPSSTNPTRPYTINTIDEHLDMLMVCHH
LDPAIAEDVAFAESRIRRETIAAEDILQDLGAIAMMSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALQGDETSHDNSRVK
RYIAKYTINPAITHGLSHEIGSVEEGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
RGVHNTCITFLSQAAIDDGVAEKLKLKKLISPCKNTRQITKADMKHNTYCPVMDVHPETYEVRADGELLTCEPADVLPMA
QRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_ACIAD (Q6FD83)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045798.1
- ProteinModelPortal:   Q6FD83
- SMR:   Q6FD83
- STRING:   Q6FD83
- GeneID:   2879202
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1091
- NMPDR:   fig|62977.3.peg.1236
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   ASP62977:ACIAD1091-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61193; Mature: 61193

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3; PS00024 HEMOPEXIN

Important sites: ACT_SITE 319-319 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMSRRAYAEMFGPTVGDRVRLADTELFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLL
CCCCHHHHHHHHCCCCCCEEEEECCEEEEEEHHHHHHCCCEEECCCCEEEECCCCCHHHH
ADEVADTVITNALIVDWWGIVKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAG
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCEEEECCCCHHEEEC
EGQILTAGGIDTHIHWICPQQVETALMSGVTTMVGGGTGPAAGTSATTVTPGPWHIGTML
CCCEEEECCCCCEEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
QAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVVGLKLHEDWGSTPAAIDNCLSVADEFDV
HHHHCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCE
QVAIHTDTLNESGFLEETLAAFKNRTIHTYHTEGAGGGHAPDILKAIGQANVLPSSTNPT
EEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCC
RPYTINTIDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILQDLGAIAMMSSDS
CCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCH
QAMGRVGEVIIRTWQTAHKMKVQRGALQGDETSHDNSRVKRYIAKYTINPAITHGLSHEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHCC
GSVEEGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
CCCCCCCEEEEEEECCHHCCCCCCCEEECCEEEECCCCCCCCCCCCCCCCEECCCCCCCC
RGVHNTCITFLSQAAIDDGVAEKLKLKKLISPCKNTRQITKADMKHNTYCPVMDVHPETY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCE
EVRADGELLTCEPADVLPMAQRYFLF
EEEECCCEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure
MKMSRRAYAEMFGPTVGDRVRLADTELFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLL
CCCCHHHHHHHHCCCCCCEEEEECCEEEEEEHHHHHHCCCEEECCCCEEEECCCCCHHHH
ADEVADTVITNALIVDWWGIVKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAG
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCCEEEECCCCHHEEEC
EGQILTAGGIDTHIHWICPQQVETALMSGVTTMVGGGTGPAAGTSATTVTPGPWHIGTML
CCCEEEECCCCCEEEEECHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
QAIDDLPMNIGLLGKGNLSLPDPIREQIKAGVVGLKLHEDWGSTPAAIDNCLSVADEFDV
HHHHCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCE
QVAIHTDTLNESGFLEETLAAFKNRTIHTYHTEGAGGGHAPDILKAIGQANVLPSSTNPT
EEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCC
RPYTINTIDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILQDLGAIAMMSSDS
CCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCH
QAMGRVGEVIIRTWQTAHKMKVQRGALQGDETSHDNSRVKRYIAKYTINPAITHGLSHEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHCC
GSVEEGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYP
CCCCCCCEEEEEEECCHHCCCCCCCEEECCEEEECCCCCCCCCCCCCCCCEECCCCCCCC
RGVHNTCITFLSQAAIDDGVAEKLKLKKLISPCKNTRQITKADMKHNTYCPVMDVHPETY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCE
EVRADGELLTCEPADVLPMAQRYFLF
EEEECCCEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA