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The map label for this gene is prs [H]

Identifier: 50084169

GI number: 50084169

Start: 950541

End: 951422

Strand: Reverse

Name: prs [H]

Synonym: ACIAD0964

Alternate gene names: 50084169

Gene position: 951422-950541 (Counterclockwise)

Preceding gene: 50084171

Following gene: 50084168

Centisome position: 26.44

GC content: 39.12

Gene sequence:

>882_bases
ATGGCGATTCAATTTTTCATCAAACAACAGAAAGTGAATATCGAGTTTATACAGTTTTCAGGTGGAGAACGTCATGTCCA
ACTTAGCTCCCAACTACTTGATACATTAGGCAATACCGTCAGGGTAAGAGCTGAATTAAACAGCAGTGATGACATTCTGG
ATTATTTGCTTTTAGAAAATGTATTGATACAACACAGAAAGAATATTGAGGTCGAAATTCCGTATTTTCCTTATGCACGG
CAGGATCGTGTATGTGCTACAGGTCAAGCATTTTCACTGGATGTGTTTTGTCATCTTCTAAATATCAATATAGAAAAACA
CACCTCTATCCGAAGAAGAATTACGTTGTGGGATGCTCACAGCAATGTAATTGGGCAGCTTTTGAATGGGTACTCATCAC
ATTTAGATCTGTATCAGGTTGAACCCGTTGAAATCATCAAAACATCGCCCGCTTTGACTGAATTATTACAACAGCAACAC
ACTGTTCTGGTTTGTCCAGATCGTGGTGCAAAAGCGAGAACAGCCGCAATTGCACAATATTTTAATCCAAAAAGATCACA
GCAAATTGCAATCATTCACTGTGACAAAACACGAGAACCAACCACAGGAAAAATTACTTCAAGCGTGGTCAAAACTGGTT
CTTTGGCAGGGAAAACCGCAGTAATCACTGACGATATTTGTGACGGCGGTGCAACCTTTATTGGTATCGCAAAAGAGCTA
AGAAAACTGCAATGCGAGCACATCATCTTGTATGTCACACATGGAATTTTTAGTCGCGGTTTGGATGTGTTTGATGGACT
GATCGACCAGATATTTACCAGCAATAGTCGACCACAACAATTCCATAAAAACCTGAATGTAATTGAATTTACAGCAATTT
AA

Upstream 100 bases:

>100_bases
CAGGTAAGTGTAATTTTTTGTAATTCGAGTATTGCTATATAAATTGTCTTTATGCCACTATATATTTAATGGCTTTATGC
CACTATTAATGAGAATTCAA

Downstream 100 bases:

>100_bases
ATATTGGAGAAACATTATGAGTTTCAGAATTAATCCACTCAATGCCATCGATTTTTACAAAGCAGATCACAGACGTCAGT
ATCCTGAAGGTACAGAATAT

Product: ribose-phosphate pyrophosphokinase (phosphoribosyl pyrophosphate synthetase)

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAIQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLENVLIQHRKNIEVEIPYFPYAR
QDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQH
TVLVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKEL
RKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI

Sequences:

>Translated_293_residues
MAIQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLENVLIQHRKNIEVEIPYFPYAR
QDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQH
TVLVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKEL
RKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI
>Mature_292_residues
AIQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLENVLIQHRKNIEVEIPYFPYARQ
DRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAHSNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHT
VLVCPDRGAKARTAAIAQYFNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKELR
KLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Escherichia coli, GI1787458, Length=269, Percent_Identity=26.0223048327138, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554704, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25149168, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17554702, Length=256, Percent_Identity=26.171875, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71989924, Length=256, Percent_Identity=26.171875, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319403, Length=248, Percent_Identity=25.4032258064516, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320946, Length=239, Percent_Identity=25.1046025104602, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355239, Length=242, Percent_Identity=24.3801652892562, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33014; Mature: 32883

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLEN
CEEEEEEEECCCEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
VLIQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAH
HHHHHCCCCEEECCCCCCCCCCCEEECCCEEEHHHEEEEHCCCCHHCCCCEEEEEEEECH
SNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHTVLVCPDRGAKARTAAIAQY
HHHHHHHHHHHHHCCCEEEECCHHEEECCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
FNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKEL
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI
HHHHHHEEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEC
>Mature Secondary Structure 
AIQFFIKQQKVNIEFIQFSGGERHVQLSSQLLDTLGNTVRVRAELNSSDDILDYLLLEN
EEEEEEEECCCEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
VLIQHRKNIEVEIPYFPYARQDRVCATGQAFSLDVFCHLLNINIEKHTSIRRRITLWDAH
HHHHHCCCCEEECCCCCCCCCCCEEECCCEEEHHHEEEEHCCCCHHCCCCEEEEEEEECH
SNVIGQLLNGYSSHLDLYQVEPVEIIKTSPALTELLQQQHTVLVCPDRGAKARTAAIAQY
HHHHHHHHHHHHHCCCEEEECCHHEEECCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
FNPKRSQQIAIIHCDKTREPTTGKITSSVVKTGSLAGKTAVITDDICDGGATFIGIAKEL
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHH
RKLQCEHIILYVTHGIFSRGLDVFDGLIDQIFTSNSRPQQFHKNLNVIEFTAI
HHHHHHEEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA