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The map label for this gene is hisC

Identifier: 50083893

GI number: 50083893

Start: 657635

End: 658720

Strand: Direct

Name: hisC

Synonym: ACIAD0664

Alternate gene names: 50083893

Gene position: 657635-658720 (Clockwise)

Preceding gene: 50083892

Following gene: 50083895

Centisome position: 18.27

GC content: 38.95

Gene sequence:

>1086_bases
ATGAATGTCACTAATGAAAAAATGCGTTTCTGGAGTCCAGAGGTTCGTGAGTTAGAGCCTTATGTACCTGGTGAGCAACC
TAAAATCCAGAACTTACTTAAACTCAATACCAATGAAAATCCGTATCCACCTTCGCCTAAAGTAAAAGCAGCAGTAGAGA
CTGTACTGGTAGATCAGGCAGACGCATTGCGTTTATATCCTGATCCAGATGCATCATTGCTAAAACAGGCAATTGCGAAA
CAGCAGCATTTGAGTGTGGAACAGGTGTTTGTAGGCAATGGTTCAGATGAAGTGCTTGCACATATTTTTAAAGCATTCTT
CATTCAAGATGAACCAATTTTATATCCCGATATTAGCTACAGCTTTTATCCAGTTTATAGCCAGTTCTTTGGTGTACAAA
CCAAACAAATTCCACTGAATGATCATTTCGAAATTGTCGTAGAAGATTATCAGCAGAATAATGGCGGTATTATTATTGCT
AATCCAAATGCACCCACCAGCATAGCGCTTTCATTGAAAAACATTGAGCAAATTCTAAAGAATAATCCCGATCGTGTAGT
CGTAATTGACGAAGCCTATGTCGATTTTGGTGCCGAATCTGCTGCGAGTTTGGTAAACCAGTATGATAATTTGGTCGTGT
GTCAAACCACCTCAAAATCACGATCTCTGGCAGGTTTACGCGTCGGGTATGCACTTGCACAAGCACATCTCATTGCTGCA
CTTGAAGCAGTGAAAAACAGTTTCAATTCTTATCCCATTGATCGTTTTGCCATAGCTGCGGCAGTAGCATCTTTTGAAGA
TCAAGCTTATTTTGAAGAACAGTGTTTAAAAGTGATTCAAAGCCGCGAACAATTGATTGAGCAGCTTGAAACTATAGGGT
TTGACGTATTGCCATCTAAGGCAAACTTTATTTTTGTGACACATCCTGCTCATGTTGCAATTGAGTTAGCAAAAGCATTG
CGTGAACAAGGGATTATTGTGCGTCATTTCAATAAACCACGTATCAATCAATATCTAAGAATTACTGTAGGCACAGACGA
GCAGAATCAGCGCTTAGTAAATACTTTAAAACTATTTATTAATTAA

Upstream 100 bases:

>100_bases
GCACGTTATCGTTATCAGTAAGTATTAATATTTTAGCAAGATCAGAGCTTAGTAACTGCTCTACGGGGCTGATTTTCAGC
CCTTTTTTGAGAATAGAAAG

Downstream 100 bases:

>100_bases
GCCGTGCTTTGCATGCTTTGCCATGTATTGATTAGATTCAGCATGGCAGAGACTTTATCAAAACATTCCTGATATTCAGC
CTCAGAGTTTGATGCGATGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNVTNEKMRFWSPEVRELEPYVPGEQPKIQNLLKLNTNENPYPPSPKVKAAVETVLVDQADALRLYPDPDASLLKQAIAK
QQHLSVEQVFVGNGSDEVLAHIFKAFFIQDEPILYPDISYSFYPVYSQFFGVQTKQIPLNDHFEIVVEDYQQNNGGIIIA
NPNAPTSIALSLKNIEQILKNNPDRVVVIDEAYVDFGAESAASLVNQYDNLVVCQTTSKSRSLAGLRVGYALAQAHLIAA
LEAVKNSFNSYPIDRFAIAAAVASFEDQAYFEEQCLKVIQSREQLIEQLETIGFDVLPSKANFIFVTHPAHVAIELAKAL
REQGIIVRHFNKPRINQYLRITVGTDEQNQRLVNTLKLFIN

Sequences:

>Translated_361_residues
MNVTNEKMRFWSPEVRELEPYVPGEQPKIQNLLKLNTNENPYPPSPKVKAAVETVLVDQADALRLYPDPDASLLKQAIAK
QQHLSVEQVFVGNGSDEVLAHIFKAFFIQDEPILYPDISYSFYPVYSQFFGVQTKQIPLNDHFEIVVEDYQQNNGGIIIA
NPNAPTSIALSLKNIEQILKNNPDRVVVIDEAYVDFGAESAASLVNQYDNLVVCQTTSKSRSLAGLRVGYALAQAHLIAA
LEAVKNSFNSYPIDRFAIAAAVASFEDQAYFEEQCLKVIQSREQLIEQLETIGFDVLPSKANFIFVTHPAHVAIELAKAL
REQGIIVRHFNKPRINQYLRITVGTDEQNQRLVNTLKLFIN
>Mature_361_residues
MNVTNEKMRFWSPEVRELEPYVPGEQPKIQNLLKLNTNENPYPPSPKVKAAVETVLVDQADALRLYPDPDASLLKQAIAK
QQHLSVEQVFVGNGSDEVLAHIFKAFFIQDEPILYPDISYSFYPVYSQFFGVQTKQIPLNDHFEIVVEDYQQNNGGIIIA
NPNAPTSIALSLKNIEQILKNNPDRVVVIDEAYVDFGAESAASLVNQYDNLVVCQTTSKSRSLAGLRVGYALAQAHLIAA
LEAVKNSFNSYPIDRFAIAAAVASFEDQAYFEEQCLKVIQSREQLIEQLETIGFDVLPSKANFIFVTHPAHVAIELAKAL
REQGIIVRHFNKPRINQYLRITVGTDEQNQRLVNTLKLFIN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=31.3725490196078, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1788722, Length=278, Percent_Identity=27.3381294964029, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=384, Percent_Identity=30.46875, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_ACIAD (Q6FEC7)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045403.1
- ProteinModelPortal:   Q6FEC7
- SMR:   Q6FEC7
- STRING:   Q6FEC7
- GeneID:   2878925
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0664
- NMPDR:   fig|62977.3.peg.362
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MQAELND
- PhylomeDB:   Q6FEC7
- ProtClustDB:   PRK05387
- BioCyc:   ASP62977:ACIAD0664-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40591; Mature: 40591

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTNEKMRFWSPEVRELEPYVPGEQPKIQNLLKLNTNENPYPPSPKVKAAVETVLVDQA
CCCCCCHHHCCCCCHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHCCC
DALRLYPDPDASLLKQAIAKQQHLSVEQVFVGNGSDEVLAHIFKAFFIQDEPILYPDISY
CCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCC
SFYPVYSQFFGVQTKQIPLNDHFEIVVEDYQQNNGGIIIANPNAPTSIALSLKNIEQILK
CCHHHHHHHHCCCEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHH
NNPDRVVVIDEAYVDFGAESAASLVNQYDNLVVCQTTSKSRSLAGLRVGYALAQAHLIAA
CCCCEEEEEEHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LEAVKNSFNSYPIDRFAIAAAVASFEDQAYFEEQCLKVIQSREQLIEQLETIGFDVLPSK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
ANFIFVTHPAHVAIELAKALREQGIIVRHFNKPRINQYLRITVGTDEQNQRLVNTLKLFI
CCEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
N
C
>Mature Secondary Structure
MNVTNEKMRFWSPEVRELEPYVPGEQPKIQNLLKLNTNENPYPPSPKVKAAVETVLVDQA
CCCCCCHHHCCCCCHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHCCC
DALRLYPDPDASLLKQAIAKQQHLSVEQVFVGNGSDEVLAHIFKAFFIQDEPILYPDISY
CCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCC
SFYPVYSQFFGVQTKQIPLNDHFEIVVEDYQQNNGGIIIANPNAPTSIALSLKNIEQILK
CCHHHHHHHHCCCEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHH
NNPDRVVVIDEAYVDFGAESAASLVNQYDNLVVCQTTSKSRSLAGLRVGYALAQAHLIAA
CCCCEEEEEEHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LEAVKNSFNSYPIDRFAIAAAVASFEDQAYFEEQCLKVIQSREQLIEQLETIGFDVLPSK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
ANFIFVTHPAHVAIELAKALREQGIIVRHFNKPRINQYLRITVGTDEQNQRLVNTLKLFI
CCEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA