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The map label for this gene is proA

Identifier: 50083785

GI number: 50083785

Start: 538888

End: 540153

Strand: Reverse

Name: proA

Synonym: ACIAD0547

Alternate gene names: 50083785

Gene position: 540153-538888 (Counterclockwise)

Preceding gene: 50083787

Following gene: 50083779

Centisome position: 15.01

GC content: 45.1

Gene sequence:

>1266_bases
ATGCAAGATTCAATTGAACAATACATGCAGGCAGTAGGTCAGCAAGCCCGCAAGGCTTCGCGCGTGCTTTCGAGCGCATC
TACTCATACTAAAAATAACGCACTTTCTGCGATTTATACTGCTTTGGTAAATCATGAGCCCGAAATTTTGGCAGCCAATG
CTGTCGATATGCAAAAAGGCCGTGACAGCCATCTGGATAGTGCCCTGCTAGATCGTTTAGAACTTACACCCACACGCTTT
AAAGGAATGTTACAGGGGTTAAAAGATGTCATCGCACTGACAGACCCAATTGGTGAAATCACCGACTTGGCCTATCGACC
ATCTGGCATTCAACTTGGCAAAATGCGCGTACCATTGGGTGTGATTGGGATGATTTATGAATCACGTCCAAATGTAACAC
TTGAAGCTGCGTCTTTAGCGCTTAAATCTGGTAATGCGATTATTTTACGTGGTGGCTCAGAAGCCCTGCAATCGAATAAG
GCAATTGCCACAGCCATTCAGCATGGCCTAAAAGTAGCTGGACTACCAGAACATGCCATTCAGGTCATAGAAACAGCAGA
TCGTGCTGCAGTTGGACAGCTCATCACCATGACAGAGTATGTCGATGTGATTGTACCACGTGGGGGTAAAAGCCTGATTG
AGCGTATCAGTAACGAAGCACGCATTCCTGTCATCAAGCATCTGGATGGCAATTGCCATGTGTTTATTGACGTTGAGGCC
GATCTTCACAAAGCATTACCCATTGCACTCAATGCAAAAACCCATCGTTATGGGGTATGTAATGCCATGGAAACCTTATT
GGTTCATGAGGAAATTGCAGAAGAGTTCTTACCACGAATTGCTGAATTATATGCAGAGAAGCATGTTGAGCTTCGCGGTT
GTCAGGAAACCCGTCGTATTTTGGGTAGCAGCGTAAAAACTGCAACAGAAGAAGACTGGTACACCGAATATTTGGCACCC
ATTTTAGCCATTAAAGTGGTCGAACATATTGATCAGGCGATTGAGCATATCAATAAATACGGTTCTCATCATACCGATGC
AATTGTGACTGAAAACTACAGCAAAGTACGCAAGTTTTTGGCTGAAGTCGATTCAAGTTCGGTGATGATCAATGCCTCTA
CCCGCTTTGCCGACGGATTTGAGTATGGGCTAGGTGCGGAAATTGGCATCTCGACCGATAAAATCCATGCACGCGGCCCA
GTCGGTTTGGAAGGATTAACCTCACAAAAATGGATTGTGTTTGGCGATGGTCAAATTCGCCATTAA

Upstream 100 bases:

>100_bases
TAAGTATCTTAAAGGAATGATCTGTTTTTTCGGTTAAAGCATTCATTGTTGCTGCATAGCCTGATACTATGAAGATCCTG
GAATCAATCTTTCTAAGCGT

Downstream 100 bases:

>100_bases
GTCAGAAAGTAATTTATAACTTTAAATAAAAGCGCCTGATTAATCTCAGGCGCTTTTATATTATTGTTCAAATACCTACA
CATCAGAAACCAGCCCGAAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQDSIEQYMQAVGQQARKASRVLSSASTHTKNNALSAIYTALVNHEPEILAANAVDMQKGRDSHLDSALLDRLELTPTRF
KGMLQGLKDVIALTDPIGEITDLAYRPSGIQLGKMRVPLGVIGMIYESRPNVTLEAASLALKSGNAIILRGGSEALQSNK
AIATAIQHGLKVAGLPEHAIQVIETADRAAVGQLITMTEYVDVIVPRGGKSLIERISNEARIPVIKHLDGNCHVFIDVEA
DLHKALPIALNAKTHRYGVCNAMETLLVHEEIAEEFLPRIAELYAEKHVELRGCQETRRILGSSVKTATEEDWYTEYLAP
ILAIKVVEHIDQAIEHINKYGSHHTDAIVTENYSKVRKFLAEVDSSSVMINASTRFADGFEYGLGAEIGISTDKIHARGP
VGLEGLTSQKWIVFGDGQIRH

Sequences:

>Translated_421_residues
MQDSIEQYMQAVGQQARKASRVLSSASTHTKNNALSAIYTALVNHEPEILAANAVDMQKGRDSHLDSALLDRLELTPTRF
KGMLQGLKDVIALTDPIGEITDLAYRPSGIQLGKMRVPLGVIGMIYESRPNVTLEAASLALKSGNAIILRGGSEALQSNK
AIATAIQHGLKVAGLPEHAIQVIETADRAAVGQLITMTEYVDVIVPRGGKSLIERISNEARIPVIKHLDGNCHVFIDVEA
DLHKALPIALNAKTHRYGVCNAMETLLVHEEIAEEFLPRIAELYAEKHVELRGCQETRRILGSSVKTATEEDWYTEYLAP
ILAIKVVEHIDQAIEHINKYGSHHTDAIVTENYSKVRKFLAEVDSSSVMINASTRFADGFEYGLGAEIGISTDKIHARGP
VGLEGLTSQKWIVFGDGQIRH
>Mature_421_residues
MQDSIEQYMQAVGQQARKASRVLSSASTHTKNNALSAIYTALVNHEPEILAANAVDMQKGRDSHLDSALLDRLELTPTRF
KGMLQGLKDVIALTDPIGEITDLAYRPSGIQLGKMRVPLGVIGMIYESRPNVTLEAASLALKSGNAIILRGGSEALQSNK
AIATAIQHGLKVAGLPEHAIQVIETADRAAVGQLITMTEYVDVIVPRGGKSLIERISNEARIPVIKHLDGNCHVFIDVEA
DLHKALPIALNAKTHRYGVCNAMETLLVHEEIAEEFLPRIAELYAEKHVELRGCQETRRILGSSVKTATEEDWYTEYLAP
ILAIKVVEHIDQAIEHINKYGSHHTDAIVTENYSKVRKFLAEVDSSSVMINASTRFADGFEYGLGAEIGISTDKIHARGP
VGLEGLTSQKWIVFGDGQIRH

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=35.8536585365854, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=35.8536585365854, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=44.0963855421687, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=35.5072463768116, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=35.5072463768116, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=40, Blast_Score=309, Evalue=5e-85,
Organism=Drosophila melanogaster, GI21357643, Length=410, Percent_Identity=39.2682926829268, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_ACIAD (Q6FEN5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045295.1
- ProteinModelPortal:   Q6FEN5
- SMR:   Q6FEN5
- STRING:   Q6FEN5
- GeneID:   2880045
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0547
- NMPDR:   fig|62977.3.peg.34
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q6FEN5
- ProtClustDB:   PRK00197
- BioCyc:   ASP62977:ACIAD0547-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46059; Mature: 46059

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDSIEQYMQAVGQQARKASRVLSSASTHTKNNALSAIYTALVNHEPEILAANAVDMQKG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCC
RDSHLDSALLDRLELTPTRFKGMLQGLKDVIALTDPIGEITDLAYRPSGIQLGKMRVPLG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECEEECCHH
VIGMIYESRPNVTLEAASLALKSGNAIILRGGSEALQSNKAIATAIQHGLKVAGLPEHAI
HHHHHHCCCCCEEEEHHHHHEECCCEEEEECCHHHHHCCHHHHHHHHHCCEECCCCHHHH
QVIETADRAAVGQLITMTEYVDVIVPRGGKSLIERISNEARIPVIKHLDGNCHVFIDVEA
HHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEECC
DLHKALPIALNAKTHRYGVCNAMETLLVHEEIAEEFLPRIAELYAEKHVELRGCQETRRI
CHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
LGSSVKTATEEDWYTEYLAPILAIKVVEHIDQAIEHINKYGSHHTDAIVTENYSKVRKFL
HCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
AEVDSSSVMINASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWIVFGDGQIR
HHCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCC
H
C
>Mature Secondary Structure
MQDSIEQYMQAVGQQARKASRVLSSASTHTKNNALSAIYTALVNHEPEILAANAVDMQKG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHCC
RDSHLDSALLDRLELTPTRFKGMLQGLKDVIALTDPIGEITDLAYRPSGIQLGKMRVPLG
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECEEECCHH
VIGMIYESRPNVTLEAASLALKSGNAIILRGGSEALQSNKAIATAIQHGLKVAGLPEHAI
HHHHHHCCCCCEEEEHHHHHEECCCEEEEECCHHHHHCCHHHHHHHHHCCEECCCCHHHH
QVIETADRAAVGQLITMTEYVDVIVPRGGKSLIERISNEARIPVIKHLDGNCHVFIDVEA
HHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCCCEEEECCCCEEEEEEECC
DLHKALPIALNAKTHRYGVCNAMETLLVHEEIAEEFLPRIAELYAEKHVELRGCQETRRI
CHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
LGSSVKTATEEDWYTEYLAPILAIKVVEHIDQAIEHINKYGSHHTDAIVTENYSKVRKFL
HCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
AEVDSSSVMINASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWIVFGDGQIR
HHCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA