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The map label for this gene is aroE

Identifier: 50083673

GI number: 50083673

Start: 419027

End: 419815

Strand: Reverse

Name: aroE

Synonym: ACIAD0418

Alternate gene names: 50083673

Gene position: 419815-419027 (Counterclockwise)

Preceding gene: 50083674

Following gene: 50083671

Centisome position: 11.67

GC content: 45.25

Gene sequence:

>789_bases
ATGACCAAGCAGTTTGCTGTAATTGGTAATCCAATTGAACAATCCCGCTCACCAGAACTTCATCATGCTTTTGCAGAAAA
GCTGGGAATTGAGCTGAACTACAGTAAACGACTTGCACCTCTCGATGGCTTTGAAGCCAATGTCAAAACTTTCTTCGATC
AAGGTGGCTTGGGAATAAATGTCACTGTTCCATTTAAGGAACAGGCATTTGCCATGTGTCATCAACTTACCGAACGTGCC
AAAATTGCTAAAGCGGTAAATACGCTCTGGATCGAAAACGGTCAACTTCATGGGGATAATACCGATGGTCAAGGTCTAGT
CGATGCCATTCAAGCTCTAAACTGGCCTTTACAGGGTACTCGTATTTTAATCCTTGGTGCTGGCGGTGCAACACGTGGCG
TGATTTATCCACTGGTTCAGGCAGGCGTCACTGAAATTGTGATTGCCAACCGCACACAACAGCGCGCTGAACAACTGGTT
CAGGATCTTGCTGGATCCGTTTCAGAAGCAACATTGAGGGTTATGACACTCGATCAGTTACACGGCAATTTTGATCTGGT
TATTAACGCAACGTCTGCGAGCCTCAGCGGCGATGCACTGGTATTGCCAGAAACACTACAGTTTAAATATGCTTATGAAA
TGGCATATGGTAAACCCTCTTCTTTTCTGGATCAGGCCAAAGCTCGCGGCGTTCCTACAACAGAAGGTTTCGGTATGTTA
GTCGGTCAGGCGATTGAAGCCTTTTCAATCTGGCATGGGGTCAAACCAAATCTTACCGATTTTTTATAA

Upstream 100 bases:

>100_bases
CATTCTGACGATTACGAAGATTAATCTTGAGCTTACAGACTTAAACTCAGACTTTTTTTGGCGTATAGTGATGCCATTTT
GAATTTCATGGATATATCGC

Downstream 100 bases:

>100_bases
ATATCAATGCTGTAGAATTCAATTTTTAAAAAAGCGAGGAATACCCTGAGATCGGGCTAAAATATAGGGTCTTGCAACCT
TAGACAAATATATTACCCCT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTKQFAVIGNPIEQSRSPELHHAFAEKLGIELNYSKRLAPLDGFEANVKTFFDQGGLGINVTVPFKEQAFAMCHQLTERA
KIAKAVNTLWIENGQLHGDNTDGQGLVDAIQALNWPLQGTRILILGAGGATRGVIYPLVQAGVTEIVIANRTQQRAEQLV
QDLAGSVSEATLRVMTLDQLHGNFDLVINATSASLSGDALVLPETLQFKYAYEMAYGKPSSFLDQAKARGVPTTEGFGML
VGQAIEAFSIWHGVKPNLTDFL

Sequences:

>Translated_262_residues
MTKQFAVIGNPIEQSRSPELHHAFAEKLGIELNYSKRLAPLDGFEANVKTFFDQGGLGINVTVPFKEQAFAMCHQLTERA
KIAKAVNTLWIENGQLHGDNTDGQGLVDAIQALNWPLQGTRILILGAGGATRGVIYPLVQAGVTEIVIANRTQQRAEQLV
QDLAGSVSEATLRVMTLDQLHGNFDLVINATSASLSGDALVLPETLQFKYAYEMAYGKPSSFLDQAKARGVPTTEGFGML
VGQAIEAFSIWHGVKPNLTDFL
>Mature_261_residues
TKQFAVIGNPIEQSRSPELHHAFAEKLGIELNYSKRLAPLDGFEANVKTFFDQGGLGINVTVPFKEQAFAMCHQLTERAK
IAKAVNTLWIENGQLHGDNTDGQGLVDAIQALNWPLQGTRILILGAGGATRGVIYPLVQAGVTEIVIANRTQQRAEQLVQ
DLAGSVSEATLRVMTLDQLHGNFDLVINATSASLSGDALVLPETLQFKYAYEMAYGKPSSFLDQAKARGVPTTEGFGMLV
GQAIEAFSIWHGVKPNLTDFL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=262, Percent_Identity=46.1832061068702, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1787983, Length=274, Percent_Identity=29.5620437956204, Blast_Score=98, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320332, Length=280, Percent_Identity=28.9285714285714, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_ACIAD (Q6FEZ7)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045183.1
- HSSP:   P15770
- ProteinModelPortal:   Q6FEZ7
- SMR:   Q6FEZ7
- STRING:   Q6FEZ7
- GeneID:   2878789
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0418
- NMPDR:   fig|62977.3.peg.1020
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   ELFFEIR
- PhylomeDB:   Q6FEZ7
- ProtClustDB:   PRK00258
- BioCyc:   ASP62977:ACIAD0418-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28410; Mature: 28279

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQFAVIGNPIEQSRSPELHHAFAEKLGIELNYSKRLAPLDGFEANVKTFFDQGGLGIN
CCCCEEEECCCHHHCCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHHHHCCCCCEEE
VTVPFKEQAFAMCHQLTERAKIAKAVNTLWIENGQLHGDNTDGQGLVDAIQALNWPLQGT
EEECCHHHHHHHHHHHHHHHHHHHHHHHHEEECCEECCCCCCCCHHHHHHHHHCCCCCCC
RILILGAGGATRGVIYPLVQAGVTEIVIANRTQQRAEQLVQDLAGSVSEATLRVMTLDQL
EEEEEECCCCCCHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHCCHHHHHEEEEEHHHH
HGNFDLVINATSASLSGDALVLPETLQFKYAYEMAYGKPSSFLDQAKARGVPTTEGFGML
CCCEEEEEEECCCCCCCCEEECCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHH
VGQAIEAFSIWHGVKPNLTDFL
HHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure 
TKQFAVIGNPIEQSRSPELHHAFAEKLGIELNYSKRLAPLDGFEANVKTFFDQGGLGIN
CCCEEEECCCHHHCCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHHHHCCCCCEEE
VTVPFKEQAFAMCHQLTERAKIAKAVNTLWIENGQLHGDNTDGQGLVDAIQALNWPLQGT
EEECCHHHHHHHHHHHHHHHHHHHHHHHHEEECCEECCCCCCCCHHHHHHHHHCCCCCCC
RILILGAGGATRGVIYPLVQAGVTEIVIANRTQQRAEQLVQDLAGSVSEATLRVMTLDQL
EEEEEECCCCCCHHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHCCHHHHHEEEEEHHHH
HGNFDLVINATSASLSGDALVLPETLQFKYAYEMAYGKPSSFLDQAKARGVPTTEGFGML
CCCEEEEEEECCCCCCCCEEECCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHH
VGQAIEAFSIWHGVKPNLTDFL
HHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA