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The map label for this gene is corC [H]

Identifier: 50083671

GI number: 50083671

Start: 417651

End: 418490

Strand: Reverse

Name: corC [H]

Synonym: ACIAD0416

Alternate gene names: 50083671

Gene position: 418490-417651 (Counterclockwise)

Preceding gene: 50083673

Following gene: 50083670

Centisome position: 11.63

GC content: 45.95

Gene sequence:

>840_bases
ATGCACGAGGAATCAGGCCCATCGTGGGGTATGCGCGGCTTACGAAAATGGCTCGGTACTGCGCCAGAAACACGCGATGA
ACTGCTTAAATTAGTTCAAGATTCACGTCGTTTTTTAGAACCCGATACCGTGGCGATGCTTGAAGGTGTCCTTGACCTTC
CTGCCACAAAAGTACGCGAAGTCATGACTCCTCGCACCTCAATCATTAGCTTGCAAGAAGACGACGAGTTGCTCGATATT
CTGCATGTTTTGATTGAATCGGCACATTCCCGCTTTCCGGTTTTTTCTTCTGATCAGCCAGATAATGTCGTTGGAATTCT
TCTTGCCAAGGATCTTCTGCCGTTCTTGACAGAGCCCAGCGCCAAGGTCGATGTCCGTGCGCTGATGCGCCAGCCATTAT
TTGTACCTGAAAGCGCCCGCTCAGATCAGGTATTGCGTATGCTCAAACATACCCAAACACATATTGCGGTCGTCATTGAT
GAATATGGCACCACTTCTGGTCTGGTAACCCTTGAAGATATTCTTGAAGAAATCGTGGGTGAAATCGAAGATGAGCATGA
CAATGTCGATGAAGAAGCGCAATACATTGTGCCAGATCATGCGCATACCACAGCCAATTCATGGATGGTACAAGCACTTA
CACCAATCGAACACTTTAATACTGTTTTAGATGCTGATTTTTCTGACGATGAAGTAGAAACTGTCGGCGGCTTATTGCTT
CAAGAAATTGGATTGGTGAGTGACCTACAAGGTCAGGTGATCGAACTGGATGACTGGCAATTTACAATTATTGAAGCAGA
TGCACGCACTATTCATCTGATTCGAGCTGTACATAAATGA

Upstream 100 bases:

>100_bases
TGAATCATTTACTTTTTCCCGCCGATTGGATGATGCATAAGCACATTTTCTTCGGTATGATTAAAATTCATTTTTAGCAT
AAGAGTCTTTAGGAAAGATC

Downstream 100 bases:

>100_bases
GAGCATACTTTGAGCAGCTGTTAGGCAATTCCCGACAGCAAAAACAGCTTCCTTTTATTTTTCCTTTTTTAATTTCGCTA
TGTTCTGGCGCAATATTTAG

Product: magnesium and cobalt efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MHEESGPSWGMRGLRKWLGTAPETRDELLKLVQDSRRFLEPDTVAMLEGVLDLPATKVREVMTPRTSIISLQEDDELLDI
LHVLIESAHSRFPVFSSDQPDNVVGILLAKDLLPFLTEPSAKVDVRALMRQPLFVPESARSDQVLRMLKHTQTHIAVVID
EYGTTSGLVTLEDILEEIVGEIEDEHDNVDEEAQYIVPDHAHTTANSWMVQALTPIEHFNTVLDADFSDDEVETVGGLLL
QEIGLVSDLQGQVIELDDWQFTIIEADARTIHLIRAVHK

Sequences:

>Translated_279_residues
MHEESGPSWGMRGLRKWLGTAPETRDELLKLVQDSRRFLEPDTVAMLEGVLDLPATKVREVMTPRTSIISLQEDDELLDI
LHVLIESAHSRFPVFSSDQPDNVVGILLAKDLLPFLTEPSAKVDVRALMRQPLFVPESARSDQVLRMLKHTQTHIAVVID
EYGTTSGLVTLEDILEEIVGEIEDEHDNVDEEAQYIVPDHAHTTANSWMVQALTPIEHFNTVLDADFSDDEVETVGGLLL
QEIGLVSDLQGQVIELDDWQFTIIEADARTIHLIRAVHK
>Mature_279_residues
MHEESGPSWGMRGLRKWLGTAPETRDELLKLVQDSRRFLEPDTVAMLEGVLDLPATKVREVMTPRTSIISLQEDDELLDI
LHVLIESAHSRFPVFSSDQPDNVVGILLAKDLLPFLTEPSAKVDVRALMRQPLFVPESARSDQVLRMLKHTQTHIAVVID
EYGTTSGLVTLEDILEEIVGEIEDEHDNVDEEAQYIVPDHAHTTANSWMVQALTPIEHFNTVLDADFSDDEVETVGGLLL
QEIGLVSDLQGQVIELDDWQFTIIEADARTIHLIRAVHK

Specific function: Plays a role in the transport of magnesium and cobalt ions [H]

COG id: COG4535

COG function: function code P; Putative Mg2+ and Co2+ transporter CorC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=247, Percent_Identity=26.7206477732794, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786879, Length=260, Percent_Identity=43.0769230769231, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1788119, Length=236, Percent_Identity=32.2033898305085, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082033, Length=248, Percent_Identity=26.2096774193548, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693175, Length=223, Percent_Identity=27.3542600896861, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790664, Length=200, Percent_Identity=30, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324512, Length=168, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 31352; Mature: 31352

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEESGPSWGMRGLRKWLGTAPETRDELLKLVQDSRRFLEPDTVAMLEGVLDLPATKVRE
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
VMTPRTSIISLQEDDELLDILHVLIESAHSRFPVFSSDQPDNVVGILLAKDLLPFLTEPS
HHCCCHHEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AKVDVRALMRQPLFVPESARSDQVLRMLKHTQTHIAVVIDEYGTTSGLVTLEDILEEIVG
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHH
EIEDEHDNVDEEAQYIVPDHAHTTANSWMVQALTPIEHFNTVLDADFSDDEVETVGGLLL
HHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHH
QEIGLVSDLQGQVIELDDWQFTIIEADARTIHLIRAVHK
HHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MHEESGPSWGMRGLRKWLGTAPETRDELLKLVQDSRRFLEPDTVAMLEGVLDLPATKVRE
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH
VMTPRTSIISLQEDDELLDILHVLIESAHSRFPVFSSDQPDNVVGILLAKDLLPFLTEPS
HHCCCHHEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
AKVDVRALMRQPLFVPESARSDQVLRMLKHTQTHIAVVIDEYGTTSGLVTLEDILEEIVG
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHH
EIEDEHDNVDEEAQYIVPDHAHTTANSWMVQALTPIEHFNTVLDADFSDDEVETVGGLLL
HHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHH
QEIGLVSDLQGQVIELDDWQFTIIEADARTIHLIRAVHK
HHHHHHHHCCCCEEEECCCEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]