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The map label for this gene is znuA [H]

Identifier: 50083461

GI number: 50083461

Start: 177514

End: 178368

Strand: Direct

Name: znuA [H]

Synonym: ACIAD0177

Alternate gene names: 50083461

Gene position: 177514-178368 (Clockwise)

Preceding gene: 50083457

Following gene: 50083462

Centisome position: 4.93

GC content: 42.11

Gene sequence:

>855_bases
TTGTGGTTTGTCATGTTGCGATTTGCGCTAATGTGTTTTGTTACTTTGGTAAGTGCGGTAAGTTGGGCTCAAGGACCACT
TGTGGTTTCAACGCATCCTTTATATTTGATCGCCAAAGAAGTCACACAGGGGGTAGAAGAACCCCAACTATTGTTAGGTA
ATCAAAGTGGACACGATATTCAACTGACTCCAGCACATCGTAAAGCCATTCAGGATGCATCATTGGTGGTCTGGTTGGGT
AAAACTCATGAAGCGCCTTTAGCTAAGCTGCTTGATAACAACCCGAAAGCGATTTCTATCATCAATTCTCAAATTGTAAC
GGGACTTCCACAACGAACTACACGTGGTGTACCTATTCCAAATACAGTCGACACACATGTGTGGCTCGATCCAAATAATG
CTATTCGTATTGGATTCTTTATAGCAGCTTTGCGTTCACAACAAATGCCAGAAAATCAAACCAAATACTGGAATAACGCG
CGTAAATTTGCGCGTGAAATGCTACAAGCTGCCCAACCCTATAATACAACAGCCAGTCCAAAACCTTACTGGTCATATCA
TGATGCCTATCAATATCTAGAGCGTGCCCTTAATTTGAAATTTGCAGGTGCCATGACAGATGATCCGCATGTTGCACCCA
CTGTGGCTCAGATCAAGTATTTAAATGATAATCGTCCAAGTGAACGTATGTGTCTGATGGCAGAAGCACATGCCAGTAAA
AATCAATATCAAAAGCTAAACCCAATTGTGTTTGAAGCAGTAGACGAAAGTCTGACAGGTGAAAGTGACTTTATCGTCGC
TTGGCAAAAATTAGCCAGTCAAACCGTGAAATGTGTGCAAAGCGCAAGCAAATAA

Upstream 100 bases:

>100_bases
CAGATTTTTACCAAATATTAACATGAACTCATAGATGTTTCGATTAGGCGTAGGTGTTTTTACGAATTTGTTATAATATA
ACACAAGTCAAAATTAAGAT

Downstream 100 bases:

>100_bases
CTTGGTTATTGTGAATCGGTTAACACTCTAGGTCGGGCAAGTAATCTTAGAAAAAAACATGACTTAGGTCGGGAAATGAT
TGCATGTTTAGGGGGGGGGG

Product: high affinity Zn ABC transporter periplasmic substrate-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MWFVMLRFALMCFVTLVSAVSWAQGPLVVSTHPLYLIAKEVTQGVEEPQLLLGNQSGHDIQLTPAHRKAIQDASLVVWLG
KTHEAPLAKLLDNNPKAISIINSQIVTGLPQRTTRGVPIPNTVDTHVWLDPNNAIRIGFFIAALRSQQMPENQTKYWNNA
RKFAREMLQAAQPYNTTASPKPYWSYHDAYQYLERALNLKFAGAMTDDPHVAPTVAQIKYLNDNRPSERMCLMAEAHASK
NQYQKLNPIVFEAVDESLTGESDFIVAWQKLASQTVKCVQSASK

Sequences:

>Translated_284_residues
MWFVMLRFALMCFVTLVSAVSWAQGPLVVSTHPLYLIAKEVTQGVEEPQLLLGNQSGHDIQLTPAHRKAIQDASLVVWLG
KTHEAPLAKLLDNNPKAISIINSQIVTGLPQRTTRGVPIPNTVDTHVWLDPNNAIRIGFFIAALRSQQMPENQTKYWNNA
RKFAREMLQAAQPYNTTASPKPYWSYHDAYQYLERALNLKFAGAMTDDPHVAPTVAQIKYLNDNRPSERMCLMAEAHASK
NQYQKLNPIVFEAVDESLTGESDFIVAWQKLASQTVKCVQSASK
>Mature_284_residues
MWFVMLRFALMCFVTLVSAVSWAQGPLVVSTHPLYLIAKEVTQGVEEPQLLLGNQSGHDIQLTPAHRKAIQDASLVVWLG
KTHEAPLAKLLDNNPKAISIINSQIVTGLPQRTTRGVPIPNTVDTHVWLDPNNAIRIGFFIAALRSQQMPENQTKYWNNA
RKFAREMLQAAQPYNTTASPKPYWSYHDAYQYLERALNLKFAGAMTDDPHVAPTVAQIKYLNDNRPSERMCLMAEAHASK
NQYQKLNPIVFEAVDESLTGESDFIVAWQKLASQTVKCVQSASK

Specific function: Involved in the high-affinity zinc uptake transport system. Required for survival and normal growth under low Zn (2+) concentrations. Also required for virulence and intracellular growth in macrophages [H]

COG id: COG4531

COG function: function code P; ABC-type Zn2+ transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=257, Percent_Identity=25.6809338521401, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 31858; Mature: 31858

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFVMLRFALMCFVTLVSAVSWAQGPLVVSTHPLYLIAKEVTQGVEEPQLLLGNQSGHDI
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEEHHHHCCCCCCCEEECCCCCCEE
QLTPAHRKAIQDASLVVWLGKTHEAPLAKLLDNNPKAISIINSQIVTGLPQRTTRGVPIP
EECHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCCC
NTVDTHVWLDPNNAIRIGFFIAALRSQQMPENQTKYWNNARKFAREMLQAAQPYNTTASP
CCCCCEEEECCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPYWSYHDAYQYLERALNLKFAGAMTDDPHVAPTVAQIKYLNDNRPSERMCLMAEAHASK
CCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHEEECCCCCCHHHEEEHHHHHCCH
NQYQKLNPIVFEAVDESLTGESDFIVAWQKLASQTVKCVQSASK
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWFVMLRFALMCFVTLVSAVSWAQGPLVVSTHPLYLIAKEVTQGVEEPQLLLGNQSGHDI
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEEHHHHCCCCCCCEEECCCCCCEE
QLTPAHRKAIQDASLVVWLGKTHEAPLAKLLDNNPKAISIINSQIVTGLPQRTTRGVPIP
EECHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCCC
NTVDTHVWLDPNNAIRIGFFIAALRSQQMPENQTKYWNNARKFAREMLQAAQPYNTTASP
CCCCCEEEECCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPYWSYHDAYQYLERALNLKFAGAMTDDPHVAPTVAQIKYLNDNRPSERMCLMAEAHASK
CCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHEEECCCCCCHHHEEEHHHHHCCH
NQYQKLNPIVFEAVDESLTGESDFIVAWQKLASQTVKCVQSASK
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA