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The map label for this gene is pbuX [H]

Identifier: 50083424

GI number: 50083424

Start: 140409

End: 141734

Strand: Direct

Name: pbuX [H]

Synonym: ACIAD0136

Alternate gene names: 50083424

Gene position: 140409-141734 (Clockwise)

Preceding gene: 50083423

Following gene: 50083425

Centisome position: 3.9

GC content: 38.39

Gene sequence:

>1326_bases
ATGAGCACGGTAAAGAATGGAACATTAGAACAAGATAAATTGAACTGGTTTAAATATCTGCTTTTTGGTATTCAGCATGT
ATTGGTTATGATCGCTGTGCCCATTACTTCTGTATTTTTAGTTGCTAAGGCATTAAGCCTATCCGATCAGCTCACGGTTA
ATTTAATGAGTGCCACGTTTCTAGTCTGTGGTTTGGGAACATTGCTACAGTCAATAGGAGTATACAAATTTGGTTCAAGA
CTACCCTTTGTGATGATTCCAGGTGGAGCCCCTATTGTAATGTTTTTGGGGATAGCACAAGAAAAAGATCTTGCCACAGC
ATCTGGTGCAGTCATTCTCACTTCACTGTTTTATTTTATTATTTTGCCTGTATTTAAACGTTTTTTGAGATTTTTTCCGA
ATATTGTAATTGGTACATTATTGATTCTCGTATCGATCAATCTGATTAAAATTTATGGTGGCTTAGTGATTGGTAAGCCA
GACACGGCTGACTTTGCTAGTACTTTAAATATTGGACTGGCTTTTGCCACTATTGCAGCGAGTTTGTTTTTTGCACGAGT
ACTAAAAGGCACACTATCACAACTTTCGATATTACTCGGATTGATATTTGGCACCATTTTGTCTGCTTTTTTAGGGCAAA
TGCACTTTGAAACAATAACTCAGCCAACTATTTTTAGTTTGCCCACAATCATGCCGTTTGGTGTACCAAAGTTTGATTTA
GTTGCAACTATTCCACTCCTCATATTTAGTCTAATTTCAATGGTAGAAGCGACTGGTCAGACGATTGCGATTTCAGACCT
TGTCGGTAAAAAGGAGACGGCATTTGAGCGTGTACCACCCACTATCCGTGGAGATGCACTAATTTCATTATTAGGCGGTT
GGTTAGGTACATCAATGATTATTACAAGTGGTGAAAATATTGGAATTGTACGTGCTACTCAGGTTCGTTCACGTTATGTG
ACCATTATAGCTGGCATTATTTTACTCATCATTTCAGTTTTTACCCCACTTGCACATCTAGCAAACGCCATTCCTGTTGC
TGTTGTCAGTGGTACAGCCATTATTGTTTTCTCTATCATTGGTACAATCGGTATTGATATTTTGCGTCGCGTCGATCTGC
ATGAAAAAGGAAATATGTATGTCCTTGCTGGCGCTTTGACCATGGGTCTCCTTCCTATTTTAGTCAATGGTGTATACACC
AATTTCCCACACGCCTTACAACCTATTTTAAATAATGGCCTAGCAATGGGTGCATTAACAGCCATCCTCTTAAATATAGT
TTTTAGTACTCATTCACAAGCCGATGCTCATCAAGAATCAAAATAA

Upstream 100 bases:

>100_bases
AAAAATATGTTTTTAAAATTTTATTCTGGTCGGCACAATTCTTGCTTTTTAAACGTCACCCAAATCGATTTGGGTGACGT
TTAAAAACAGAGGTGGTGAT

Downstream 100 bases:

>100_bases
GGATAAATTTATGAATACTGCAAATTTTTCAGCACAGCAATTACAAGCTGAACGTTTGCTCCTTTTACCGAGCTATATTT
TATTAAAAGAAGGTTTAGTT

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSTVKNGTLEQDKLNWFKYLLFGIQHVLVMIAVPITSVFLVAKALSLSDQLTVNLMSATFLVCGLGTLLQSIGVYKFGSR
LPFVMIPGGAPIVMFLGIAQEKDLATASGAVILTSLFYFIILPVFKRFLRFFPNIVIGTLLILVSINLIKIYGGLVIGKP
DTADFASTLNIGLAFATIAASLFFARVLKGTLSQLSILLGLIFGTILSAFLGQMHFETITQPTIFSLPTIMPFGVPKFDL
VATIPLLIFSLISMVEATGQTIAISDLVGKKETAFERVPPTIRGDALISLLGGWLGTSMIITSGENIGIVRATQVRSRYV
TIIAGIILLIISVFTPLAHLANAIPVAVVSGTAIIVFSIIGTIGIDILRRVDLHEKGNMYVLAGALTMGLLPILVNGVYT
NFPHALQPILNNGLAMGALTAILLNIVFSTHSQADAHQESK

Sequences:

>Translated_441_residues
MSTVKNGTLEQDKLNWFKYLLFGIQHVLVMIAVPITSVFLVAKALSLSDQLTVNLMSATFLVCGLGTLLQSIGVYKFGSR
LPFVMIPGGAPIVMFLGIAQEKDLATASGAVILTSLFYFIILPVFKRFLRFFPNIVIGTLLILVSINLIKIYGGLVIGKP
DTADFASTLNIGLAFATIAASLFFARVLKGTLSQLSILLGLIFGTILSAFLGQMHFETITQPTIFSLPTIMPFGVPKFDL
VATIPLLIFSLISMVEATGQTIAISDLVGKKETAFERVPPTIRGDALISLLGGWLGTSMIITSGENIGIVRATQVRSRYV
TIIAGIILLIISVFTPLAHLANAIPVAVVSGTAIIVFSIIGTIGIDILRRVDLHEKGNMYVLAGALTMGLLPILVNGVYT
NFPHALQPILNNGLAMGALTAILLNIVFSTHSQADAHQESK
>Mature_440_residues
STVKNGTLEQDKLNWFKYLLFGIQHVLVMIAVPITSVFLVAKALSLSDQLTVNLMSATFLVCGLGTLLQSIGVYKFGSRL
PFVMIPGGAPIVMFLGIAQEKDLATASGAVILTSLFYFIILPVFKRFLRFFPNIVIGTLLILVSINLIKIYGGLVIGKPD
TADFASTLNIGLAFATIAASLFFARVLKGTLSQLSILLGLIFGTILSAFLGQMHFETITQPTIFSLPTIMPFGVPKFDLV
ATIPLLIFSLISMVEATGQTIAISDLVGKKETAFERVPPTIRGDALISLLGGWLGTSMIITSGENIGIVRATQVRSRYVT
IIAGIILLIISVFTPLAHLANAIPVAVVSGTAIIVFSIIGTIGIDILRRVDLHEKGNMYVLAGALTMGLLPILVNGVYTN
FPHALQPILNNGLAMGALTAILLNIVFSTHSQADAHQESK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082181, Length=439, Percent_Identity=29.1571753986333, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1790087, Length=448, Percent_Identity=24.1071428571429, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081818, Length=449, Percent_Identity=24.7216035634744, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082178, Length=445, Percent_Identity=25.6179775280899, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788843, Length=378, Percent_Identity=25.1322751322751, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47199; Mature: 47068

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVKNGTLEQDKLNWFKYLLFGIQHVLVMIAVPITSVFLVAKALSLSDQLTVNLMSATF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVCGLGTLLQSIGVYKFGSRLPFVMIPGGAPIVMFLGIAQEKDLATASGAVILTSLFYFI
HHHHHHHHHHHCCHHHCCCCCCEEEECCCCCEEHEEECCCCCCCHHHCHHHHHHHHHHHH
ILPVFKRFLRFFPNIVIGTLLILVSINLIKIYGGLVIGKPDTADFASTLNIGLAFATIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHH
SLFFARVLKGTLSQLSILLGLIFGTILSAFLGQMHFETITQPTIFSLPTIMPFGVPKFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHH
VATIPLLIFSLISMVEATGQTIAISDLVGKKETAFERVPPTIRGDALISLLGGWLGTSMI
HHHHHHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEE
ITSGENIGIVRATQVRSRYVTIIAGIILLIISVFTPLAHLANAIPVAVVSGTAIIVFSII
EECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHH
GTIGIDILRRVDLHEKGNMYVLAGALTMGLLPILVNGVYTNFPHALQPILNNGLAMGALT
HHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
AILLNIVFSTHSQADAHQESK
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
STVKNGTLEQDKLNWFKYLLFGIQHVLVMIAVPITSVFLVAKALSLSDQLTVNLMSATF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVCGLGTLLQSIGVYKFGSRLPFVMIPGGAPIVMFLGIAQEKDLATASGAVILTSLFYFI
HHHHHHHHHHHCCHHHCCCCCCEEEECCCCCEEHEEECCCCCCCHHHCHHHHHHHHHHHH
ILPVFKRFLRFFPNIVIGTLLILVSINLIKIYGGLVIGKPDTADFASTLNIGLAFATIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHH
SLFFARVLKGTLSQLSILLGLIFGTILSAFLGQMHFETITQPTIFSLPTIMPFGVPKFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHH
VATIPLLIFSLISMVEATGQTIAISDLVGKKETAFERVPPTIRGDALISLLGGWLGTSMI
HHHHHHHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEE
ITSGENIGIVRATQVRSRYVTIIAGIILLIISVFTPLAHLANAIPVAVVSGTAIIVFSII
EECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHH
GTIGIDILRRVDLHEKGNMYVLAGALTMGLLPILVNGVYTNFPHALQPILNNGLAMGALT
HHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
AILLNIVFSTHSQADAHQESK
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]