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The map label for this gene is cycA [H]

Identifier: 50083407

GI number: 50083407

Start: 118673

End: 120052

Strand: Direct

Name: cycA [H]

Synonym: ACIAD0118

Alternate gene names: 50083407

Gene position: 118673-120052 (Clockwise)

Preceding gene: 50083406

Following gene: 50083408

Centisome position: 3.3

GC content: 44.2

Gene sequence:

>1380_bases
CTGCAACGTAAACTGTCCAATCGCCATCTACAACTGATTGCGATTGGTGGTGCAATTGGTACAGGTTTATTTATGGGATC
AGGGAAAACCATCTCTCTGGCAGGGCCTTCAATTTTATATATTTACATGATCATTGGGGTCATGTTTTTCTTTTTAATGC
GCGCCATGGGTGAGCTTCTGCTTGCCAATCTGCAATATAAGTCTTTTGTGGATATGGCACATGATCTGATTGGGCCTGGG
GCAGGGTATTATTTGGGCTGGACTTACTGGCTCGGATGGGTATTGGTCGGGATTGCAGATCTGGCCGCTATTATTAACTA
TCTGAACTTTTGGCTTCCAGATGGCACGGTATTTACCCCGATGGGACAGGCACTGATCAGTGCAGGCTGTGTGCTACTTG
TACTTGGACTCAACCTGTTGACGGTTCGTCTGTTTGGCGAAATCGAGTTCTGGTTTGCGCTTATCAAGATTTTAGCGATT
GTGGGGCTGATTGGTGTTGGTGGATACATGGTATTTAGCCATTTTCAGGCGCCCGCTGGTACAGTCGCAGCGATAAGTAA
CGTGTGGTCGGAAGGTGGTATGTTCCCTAAAGGAGTTACTGGCTTTCTGGCAGGCTTTCAGATTGCTGTATTTGCTTTTG
TTGGTGTTGAGCTGGTTGGAACCACAGCCGCAGAAACCAGGGATCCACAGAAGAATTTACCCAAAGCCATTAATGCGATT
CCTGTTCGTATTATCTTATTTTATGTGTTGGCGTTATTTGTGGTGATGTCTGTCACGCCATGGAATCACATTAGTGCAGA
TAAAAGTCCTTTTGTTGAATTATTCTTGCATGCGGGTATCCCAACATCAGCGATTATTATGAATCTGGTGGTGTTGTCAT
CTGTCATGTCATCGATGAATAGTGGTGTTTTCTCTACAAGCCGCATGTTATTTGGATTATCGCGTGATGGACAGGCACCT
CAGGCGTTTGCACATTTATCACGCCGTGCTGTTCCTGCAAATGGGTTGTTGTTTTCCTGCTTTTTCATCATGGCAGGCGC
AGCCTTACAATATTTTGTTCCTAACACCATGGAGGCATTTACGCTGGCTAGTTCGCTTTGCGTGATCCTGTTTATTAGTG
TGTGGGGCATGATTATGGTTTGCTATCTGCGTTATCGTAAATTACGCCCAGAATTGCATGCGCAGTCAACCTTCAAAATG
CCAGGTGGTATCTGGATGTCGTATATCGTGCTGGCATTTTTAATGTTTACATTGGTGATTCTTGCATTAGAACCAGATAC
GCTAAAAGCTCTTTATATCAGCCCTTTATGGTTAATTCTTCTGGCACTGACTTATCAGTTTATGTATAAGCCACGTTTAA
AACGCTTAATGCACAATTAA

Upstream 100 bases:

>100_bases
ATTGAGACAGTCTGAACGTGTTTGAAAGGAAGTTTTTTAAAAAGGATGTTAAATCATGACTACAGGACGTCATTCTGAGG
GCGAGCATGCCCCACATGAC

Downstream 100 bases:

>100_bases
ATGATGCAATATTGGAGAGCATGATTTAAAGCATGCTCTCTTAACTTAAGAATGTATCAGAGCATAGACCTTCATTCAGA
TCTAGCCTATACGCATAGCC

Product: amino acid APC transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQRKLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILYIYMIIGVMFFFLMRAMGELLLANLQYKSFVDMAHDLIGPG
AGYYLGWTYWLGWVLVGIADLAAIINYLNFWLPDGTVFTPMGQALISAGCVLLVLGLNLLTVRLFGEIEFWFALIKILAI
VGLIGVGGYMVFSHFQAPAGTVAAISNVWSEGGMFPKGVTGFLAGFQIAVFAFVGVELVGTTAAETRDPQKNLPKAINAI
PVRIILFYVLALFVVMSVTPWNHISADKSPFVELFLHAGIPTSAIIMNLVVLSSVMSSMNSGVFSTSRMLFGLSRDGQAP
QAFAHLSRRAVPANGLLFSCFFIMAGAALQYFVPNTMEAFTLASSLCVILFISVWGMIMVCYLRYRKLRPELHAQSTFKM
PGGIWMSYIVLAFLMFTLVILALEPDTLKALYISPLWLILLALTYQFMYKPRLKRLMHN

Sequences:

>Translated_459_residues
MQRKLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILYIYMIIGVMFFFLMRAMGELLLANLQYKSFVDMAHDLIGPG
AGYYLGWTYWLGWVLVGIADLAAIINYLNFWLPDGTVFTPMGQALISAGCVLLVLGLNLLTVRLFGEIEFWFALIKILAI
VGLIGVGGYMVFSHFQAPAGTVAAISNVWSEGGMFPKGVTGFLAGFQIAVFAFVGVELVGTTAAETRDPQKNLPKAINAI
PVRIILFYVLALFVVMSVTPWNHISADKSPFVELFLHAGIPTSAIIMNLVVLSSVMSSMNSGVFSTSRMLFGLSRDGQAP
QAFAHLSRRAVPANGLLFSCFFIMAGAALQYFVPNTMEAFTLASSLCVILFISVWGMIMVCYLRYRKLRPELHAQSTFKM
PGGIWMSYIVLAFLMFTLVILALEPDTLKALYISPLWLILLALTYQFMYKPRLKRLMHN
>Mature_459_residues
MQRKLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILYIYMIIGVMFFFLMRAMGELLLANLQYKSFVDMAHDLIGPG
AGYYLGWTYWLGWVLVGIADLAAIINYLNFWLPDGTVFTPMGQALISAGCVLLVLGLNLLTVRLFGEIEFWFALIKILAI
VGLIGVGGYMVFSHFQAPAGTVAAISNVWSEGGMFPKGVTGFLAGFQIAVFAFVGVELVGTTAAETRDPQKNLPKAINAI
PVRIILFYVLALFVVMSVTPWNHISADKSPFVELFLHAGIPTSAIIMNLVVLSSVMSSMNSGVFSTSRMLFGLSRDGQAP
QAFAHLSRRAVPANGLLFSCFFIMAGAALQYFVPNTMEAFTLASSLCVILFISVWGMIMVCYLRYRKLRPELHAQSTFKM
PGGIWMSYIVLAFLMFTLVILALEPDTLKALYISPLWLILLALTYQFMYKPRLKRLMHN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=24.0112994350282, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI258645169, Length=156, Percent_Identity=30.1282051282051, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI181337167, Length=341, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=59.2105263157895, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=39.8678414096916, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=38.6666666666667, Blast_Score=318, Evalue=6e-88,
Organism=Escherichia coli, GI1786602, Length=456, Percent_Identity=38.5964912280702, Blast_Score=304, Evalue=1e-83,
Organism=Escherichia coli, GI48994972, Length=446, Percent_Identity=38.7892376681614, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI87081915, Length=457, Percent_Identity=37.199124726477, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789017, Length=427, Percent_Identity=33.9578454332553, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788480, Length=348, Percent_Identity=40.5172413793103, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=32.1353065539112, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI2367353, Length=413, Percent_Identity=22.2760290556901, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=220, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=482, Percent_Identity=30.9128630705394, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=429, Percent_Identity=31.2354312354312, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=31.2087912087912, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320772, Length=487, Percent_Identity=28.7474332648871, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=445, Percent_Identity=28.0898876404494, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324059, Length=483, Percent_Identity=28.3643892339545, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=436, Percent_Identity=27.9816513761468, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=429, Percent_Identity=27.972027972028, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=451, Percent_Identity=27.4944567627494, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319824, Length=450, Percent_Identity=27.3333333333333, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324553, Length=419, Percent_Identity=27.9236276849642, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319543, Length=445, Percent_Identity=27.6404494382022, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320251, Length=469, Percent_Identity=26.0127931769723, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319608, Length=352, Percent_Identity=26.1363636363636, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321053, Length=398, Percent_Identity=27.3869346733668, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=443, Percent_Identity=25.0564334085779, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=423, Percent_Identity=28.3687943262411, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=483, Percent_Identity=24.0165631469979, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161077963, Length=178, Percent_Identity=24.7191011235955, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50478; Mature: 50478

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILYIYMIIGVMFFFLMRAMGELL
CCCCCCCCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LANLQYKSFVDMAHDLIGPGAGYYLGWTYWLGWVLVGIADLAAIINYLNFWLPDGTVFTP
HHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECH
MGQALISAGCVLLVLGLNLLTVRLFGEIEFWFALIKILAIVGLIGVGGYMVFSHFQAPAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TVAAISNVWSEGGMFPKGVTGFLAGFQIAVFAFVGVELVGTTAAETRDPQKNLPKAINAI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHH
PVRIILFYVLALFVVMSVTPWNHISADKSPFVELFLHAGIPTSAIIMNLVVLSSVMSSMN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
SGVFSTSRMLFGLSRDGQAPQAFAHLSRRAVPANGLLFSCFFIMAGAALQYFVPNTMEAF
CCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
TLASSLCVILFISVWGMIMVCYLRYRKLRPELHAQSTFKMPGGIWMSYIVLAFLMFTLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LALEPDTLKALYISPLWLILLALTYQFMYKPRLKRLMHN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQRKLSNRHLQLIAIGGAIGTGLFMGSGKTISLAGPSILYIYMIIGVMFFFLMRAMGELL
CCCCCCCCCEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LANLQYKSFVDMAHDLIGPGAGYYLGWTYWLGWVLVGIADLAAIINYLNFWLPDGTVFTP
HHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECH
MGQALISAGCVLLVLGLNLLTVRLFGEIEFWFALIKILAIVGLIGVGGYMVFSHFQAPAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TVAAISNVWSEGGMFPKGVTGFLAGFQIAVFAFVGVELVGTTAAETRDPQKNLPKAINAI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHH
PVRIILFYVLALFVVMSVTPWNHISADKSPFVELFLHAGIPTSAIIMNLVVLSSVMSSMN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
SGVFSTSRMLFGLSRDGQAPQAFAHLSRRAVPANGLLFSCFFIMAGAALQYFVPNTMEAF
CCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
TLASSLCVILFISVWGMIMVCYLRYRKLRPELHAQSTFKMPGGIWMSYIVLAFLMFTLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LALEPDTLKALYISPLWLILLALTYQFMYKPRLKRLMHN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]