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The map label for this gene is lldP [H]

Identifier: 50083396

GI number: 50083396

Start: 105761

End: 107416

Strand: Direct

Name: lldP [H]

Synonym: ACIAD0106

Alternate gene names: 50083396

Gene position: 105761-107416 (Clockwise)

Preceding gene: 50083393

Following gene: 50083397

Centisome position: 2.94

GC content: 43.66

Gene sequence:

>1656_bases
ATGCTTCAAGTATGGCAACAAACCTATAATCCACTTGGTAATATTTGGCTGTCCAGTTTGGTCGCCCTGATTCCCATTAT
TTTCTTCTTTCTGGCCCTGGCTGTTTTTCGCTTAAAAGGCAGTGTGGCGGGTACAATTACCGTCGCGATTGCACTTGTGA
TTGCATTATTCTTTTATCAAATGCCTGCTGCGATGGCATTTGGCTCCCTAATCTATGGTTTCTTTTATGGCCTATGGCCA
ATTTCATGGATTATTCTAGGTGCAGTTTTTCTGTATAAGGTCTCAGTGAAAACGGGGCAATTTGACATTATCCGTTCCAG
TATTTTGTCAATTACAGAAGACCAGCGTTTACAAATGTTATTGGTTGGATTTGCCTTCGGAACTTTCCTTGAAGGGGCGG
CAGGCTTTGGTGCACCTGTGGCGATTACCGCAGCATTGTTAATGGGATTAGGTTTTAAACCTTTATATGCTGCTGGATTA
TGCTTGATTGTCAATACAGCACCTGTTGCCTTTGGTGCGATGGGGATTCCAATTATTGTGGCTGGTCAGGTTTCGGGTGT
CGATACCATGGAAATCAGCCAGATGGTGGGTCGTCAGTTACCTTTTCTGGTGATCATTGTGCTGTTCTGGATCATGGCGA
TTATGGACGGCTGGCGTGGTGTCAAGGAAACTTGGCCTGCTGTACTGGTGGGTGGTGGTGCTTTTGCGATTGCGCAGTAT
GCCACTTCAAACTTTCTTGGGCCTGAGCTTCCAGATATCACTGCTGCAATTGCATCATTGATTAGTTTGACCGTGCTGTT
TCATTTCTGGCAGCCAAAACATATTTTCCGTTTCGAACAAGCAGAAAAGCTTGATCAGACAACGGCACCCGTACAGCAAT
ATTCGATTGGTCAAATTGCCAAAGCATGGTCGCCTTTTGCCATTTTGACAGTAATGGTGACGATCTGGAGTGTAAAACCA
TTTAAAGCACTTTTTGCAAAAGGTGGTGCTTTAGAACACTGGATTTTTAAAATCGAAGTACCTGGTTTACACCGTTTAGT
TGAAAAAATGCCACCGATTGTGTCTCAAAGTACACCTTATGATGCGATTTACAAATTTGACTGGTTCTCTGCAACAGGTA
CAGCCATCTTTATTGCAGCCGTGATCACCATCATTTTTCTAAAAATGAGTGCCAAGCAAGCTGTGGTGACATTTGGCGAA
ACAGTGAATGAGTTAAAAATACCAATTTACTCAATTGGAATGGTACTGGCTTTTGCTTTTATTGCCAATTATTCAGGCCT
TTCTGCAACACTGGCATTGGCATTATCACACACTGGGCACGCATTTACGTTCTTCTCACCATTTTTGGGTTGGCTGGGTG
TATTCCTGACAGGCTCAGATACGTCATCCAATGCATTGTTTTCGGCACTACAGGCGACCACGGCACAGCAGATTGGTATT
CCAGAAGTCTTATTGGTTGCGGCCAATACCAGTGGTGGCGTGACAGGTAAAATGATTTCTCCACAATCTATTGCGATTGC
TTGTGCGGCCGTCGGACTTGTGGGTAAAGAATCTGATTTATTCCGTTTTACTGTAAAACATAGCATCATATTCACAATCT
TTGTGGGCATCATTGTGACGGTTCAGGCGTATATTGTACCTTGGATGATCCCTTAA

Upstream 100 bases:

>100_bases
TTATCGAAATTGGTAATACCAATTTTAACGCGATAACCAGAATACCTATGATCCGTTCAAGGTAGAACATCGATACCATC
GGCATTTCAAGGAGATGAAA

Downstream 100 bases:

>100_bases
ACTGGATAGATAAAGGAATAGGTATGAGAGTGTCGGATCAAGTGGTGCAAAAGTTACAGGGCTTAATTGAGCAACGTCAC
TTAAAACAAGGTGATCGCTT

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MLQVWQQTYNPLGNIWLSSLVALIPIIFFFLALAVFRLKGSVAGTITVAIALVIALFFYQMPAAMAFGSLIYGFFYGLWP
ISWIILGAVFLYKVSVKTGQFDIIRSSILSITEDQRLQMLLVGFAFGTFLEGAAGFGAPVAITAALLMGLGFKPLYAAGL
CLIVNTAPVAFGAMGIPIIVAGQVSGVDTMEISQMVGRQLPFLVIIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQY
ATSNFLGPELPDITAAIASLISLTVLFHFWQPKHIFRFEQAEKLDQTTAPVQQYSIGQIAKAWSPFAILTVMVTIWSVKP
FKALFAKGGALEHWIFKIEVPGLHRLVEKMPPIVSQSTPYDAIYKFDWFSATGTAIFIAAVITIIFLKMSAKQAVVTFGE
TVNELKIPIYSIGMVLAFAFIANYSGLSATLALALSHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGI
PEVLLVAANTSGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTIFVGIIVTVQAYIVPWMIP

Sequences:

>Translated_551_residues
MLQVWQQTYNPLGNIWLSSLVALIPIIFFFLALAVFRLKGSVAGTITVAIALVIALFFYQMPAAMAFGSLIYGFFYGLWP
ISWIILGAVFLYKVSVKTGQFDIIRSSILSITEDQRLQMLLVGFAFGTFLEGAAGFGAPVAITAALLMGLGFKPLYAAGL
CLIVNTAPVAFGAMGIPIIVAGQVSGVDTMEISQMVGRQLPFLVIIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQY
ATSNFLGPELPDITAAIASLISLTVLFHFWQPKHIFRFEQAEKLDQTTAPVQQYSIGQIAKAWSPFAILTVMVTIWSVKP
FKALFAKGGALEHWIFKIEVPGLHRLVEKMPPIVSQSTPYDAIYKFDWFSATGTAIFIAAVITIIFLKMSAKQAVVTFGE
TVNELKIPIYSIGMVLAFAFIANYSGLSATLALALSHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGI
PEVLLVAANTSGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTIFVGIIVTVQAYIVPWMIP
>Mature_551_residues
MLQVWQQTYNPLGNIWLSSLVALIPIIFFFLALAVFRLKGSVAGTITVAIALVIALFFYQMPAAMAFGSLIYGFFYGLWP
ISWIILGAVFLYKVSVKTGQFDIIRSSILSITEDQRLQMLLVGFAFGTFLEGAAGFGAPVAITAALLMGLGFKPLYAAGL
CLIVNTAPVAFGAMGIPIIVAGQVSGVDTMEISQMVGRQLPFLVIIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQY
ATSNFLGPELPDITAAIASLISLTVLFHFWQPKHIFRFEQAEKLDQTTAPVQQYSIGQIAKAWSPFAILTVMVTIWSVKP
FKALFAKGGALEHWIFKIEVPGLHRLVEKMPPIVSQSTPYDAIYKFDWFSATGTAIFIAAVITIIFLKMSAKQAVVTFGE
TVNELKIPIYSIGMVLAFAFIANYSGLSATLALALSHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGI
PEVLLVAANTSGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTIFVGIIVTVQAYIVPWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=552, Percent_Identity=72.6449275362319, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=63.7992831541219, Blast_Score=692, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59542; Mature: 59542

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQVWQQTYNPLGNIWLSSLVALIPIIFFFLALAVFRLKGSVAGTITVAIALVIALFFYQ
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MPAAMAFGSLIYGFFYGLWPISWIILGAVFLYKVSVKTGQFDIIRSSILSITEDQRLQML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHHHHH
LVGFAFGTFLEGAAGFGAPVAITAALLMGLGFKPLYAAGLCLIVNTAPVAFGAMGIPIIV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCCCCCEEE
AGQVSGVDTMEISQMVGRQLPFLVIIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQY
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCHHHHHHH
ATSNFLGPELPDITAAIASLISLTVLFHFWQPKHIFRFEQAEKLDQTTAPVQQYSIGQIA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAWSPFAILTVMVTIWSVKPFKALFAKGGALEHWIFKIEVPGLHRLVEKMPPIVSQSTPY
HHCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCC
DAIYKFDWFSATGTAIFIAAVITIIFLKMSAKQAVVTFGETVNELKIPIYSIGMVLAFAF
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IANYSGLSATLALALSHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGI
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCC
PEVLLVAANTSGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTIFVGIIVT
CEEEEEEECCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
VQAYIVPWMIP
HHHHHHCCCCC
>Mature Secondary Structure
MLQVWQQTYNPLGNIWLSSLVALIPIIFFFLALAVFRLKGSVAGTITVAIALVIALFFYQ
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MPAAMAFGSLIYGFFYGLWPISWIILGAVFLYKVSVKTGQFDIIRSSILSITEDQRLQML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHHHHH
LVGFAFGTFLEGAAGFGAPVAITAALLMGLGFKPLYAAGLCLIVNTAPVAFGAMGIPIIV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCCCCCEEE
AGQVSGVDTMEISQMVGRQLPFLVIIVLFWIMAIMDGWRGVKETWPAVLVGGGAFAIAQY
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCHHHHHHH
ATSNFLGPELPDITAAIASLISLTVLFHFWQPKHIFRFEQAEKLDQTTAPVQQYSIGQIA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KAWSPFAILTVMVTIWSVKPFKALFAKGGALEHWIFKIEVPGLHRLVEKMPPIVSQSTPY
HHCCHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCC
DAIYKFDWFSATGTAIFIAAVITIIFLKMSAKQAVVTFGETVNELKIPIYSIGMVLAFAF
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IANYSGLSATLALALSHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFSALQATTAQQIGI
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCC
PEVLLVAANTSGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSIIFTIFVGIIVT
CEEEEEEECCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
VQAYIVPWMIP
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]