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The map label for this gene is hutU

Identifier: 49479454

GI number: 49479454

Start: 3484102

End: 3485760

Strand: Reverse

Name: hutU

Synonym: BT9727_3404

Alternate gene names: 49479454

Gene position: 3485760-3484102 (Counterclockwise)

Preceding gene: 49478310

Following gene: 49478309

Centisome position: 66.55

GC content: 41.53

Gene sequence:

>1659_bases
ATGGAAAAAGTTAAACAAACAATTCGCGCGCCAAGAGGTACTGAGTTACAAACGAAAGGGTGGGTGCAAGAAGCTGCACT
TCGTATGTTAATGAACAATTTAGATCCGGAAGTTGCTGAAAAGCCAGAAGAATTAGTTGTATATGGTGGAATCGGCCGTG
CAGCTCGTAACTGGGAAAGCTACAATGCAATTGTAGATTCATTAAAAACGTTAGAAAGCGATGAAACATTACTTGTTCAA
TCAGGAAAACCAGTTGCAATCTTTAAATCACATGAAGATGCGCCTCGCGTTCTTTTAGCGAACTCAAACTTAGTACCGAA
GTGGGCGAACTGGGATCACTTCCGTGAACTAGAGAAAAAGGGTCTTATGATGTATGGACAAATGACAGCAGGTAGCTGGA
TTTACATTGGAACACAAGGTATTTTACAAGGGACATATGAAACGTTTGGTGAAGCGGCACGTCAACATTTCGGTGGTTCA
TTAAAAGGTACATTAACACTTACTGCTGGTTTAGGTGGTATGGGCGGTGCACAACCTCTTGCTGTAACGATGAATGGCGG
TGTTGTTATCGCTATTGATGTTGATAAGCGCAGTATCGATCGCCGTATTGAAAAGAGATACTGTGATATGTATACAGAAT
CATTAGAAGAAGCATTAACGGTTGCGAACGAGTATAAAGAGAAGAAAGAACCGATTTCTATTGGTTTATTAGGAAATGCG
GCAGAGATTTTACCAGAGCTAGTGAAGCGTAATATTACGCCAGATTTAGTTACAGATCAAACATCTGCTCATGATCCATT
AAACGGTTATATTCCAGTAGGTTACACATTAGAAGAAGCAGCAAAACTTCGTGAAGAAGATCCAGAACGTTACGTACAAT
TATCAAAAGAAAGCATGACAAAACATGTGGAAGCAATGCTTACTATGCAAGCAAAAGGCGCAATTACATTTGATTACGGA
AATAACATTCGCCAAGTTGCTTTTGATGAAGGTTTGAAAAATGCATTCGATTTCCCAGGATTCGTTCCAGCATTTATCCG
TCCATTATTCTGCGAAGGAAAAGGACCATTCCGCTGGGTAGCACTTTCTGGTGACCCAGAAGATATTTATAAAACAGATG
AAGTAATTTTACGTGAGTTTGCTGATAATGAGCATTTATGTAACTGGATCCGTATGGCTCGTCAGCAAGTTGAGTTCCAA
GGTCTTCCGTCACGTATTTGTTGGCTTGGTTACGGTGAGCGTGCGAAATTTGGTCGCATCATTAATGAAATGGTTGCAAA
TGGTGAATTATCAGCACCAATCGTTATCGGCCGTGACCATTTAGATTGCGGATCAGTAGCATCTCCAAACCGTGAAACAG
AAGCGATGAAAGATGGTAGTGATGCAGTAGCTGACTGGCCAATTTTGAATGCATTAATTAACAGTGTAAACGGTGCAAGC
TGGGTATCTGTTCACCACGGTGGCGGCGTTGGTATGGGTTATTCACTTCACGCTGGAATGGTTATCGTTGCAGATGGAAC
AGAAGCAGCAGCAAAACGTATTGAGCGCGTATTAACTTCTGACCCTGGTATGGGTGTTGTTCGTCACGTGGATGCAGGGT
ATGACTTAGCTGTGGAAACAGCGAAAGAAAAAGGCGTTAACATTCCAATGATGAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAAATATTGCGTATTGGTTAAAAACGAATTATTCGATAAAAGAAAGATTAGATGTAAACGCAGCACTATAAAAT
GAGACAAGGGAGAGATTGAA

Downstream 100 bases:

>100_bases
GGAGGAGAAAAACATGCTGGACACTTTACTAATCAATATCGGTCAATTACTAACAATGGATCAAGAAGATGGCTTGTTAA
GACGGGAAGCGATGAACACG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYNAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLTMQAKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Sequences:

>Translated_552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYNAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLTMQAKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
>Mature_552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYNAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLTMQAKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=562, Percent_Identity=35.4092526690391, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI260306182, Length=623, Percent_Identity=32.5842696629214, Blast_Score=297, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71997891, Length=551, Percent_Identity=35.7531760435572, Blast_Score=341, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60751; Mature: 60751

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YNAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLTMQAKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC
>Mature Secondary Structure
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YNAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALTVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLTMQAKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA