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The map label for this gene is hutH

Identifier: 49478310

GI number: 49478310

Start: 3485784

End: 3487301

Strand: Reverse

Name: hutH

Synonym: BT9727_3405

Alternate gene names: 49478310

Gene position: 3487301-3485784 (Counterclockwise)

Preceding gene: 49481640

Following gene: 49479454

Centisome position: 66.58

GC content: 39.33

Gene sequence:

>1518_bases
ATGATTACATTAACGGGACATACATTGACAATTGAAGAAATGAAGAGGTTGTTACTTGAAGGGGAAGGTGTAACAGCTTG
TCCAAATAGTATGCAAAAGGTAGCGGAATGCCGCGAAGTAGTTGAGAAAATTGTAGAAGACGGAAAAGTCGTTTACGGTA
TTACAACTGGATTTGGAAAGTTTAGTGATGTGCTAATTCAAAAAGATGATGTAAAGGCACTTCAGCACAATTTAATTCAG
TCACATGCATGTGGGATAGGCGATCCTTTCCCTGAAGAAGTATCACGCGGTATGTTAATTTTACGAGCGAACACGATGCT
TAAAGGAGTATCTGGTGTTAGACCGCTCGTTGTAAATATGCTTCTTGAGTTTGTAAATCGCAAAATTCACCCAGTCGTTC
CGCAACAAGGTTCACTTGGTGCGAGTGGCGATTTAGCACCTTTATCTCATCTTGCGCTCGTATTATTAGGCGAAGGTGAA
GTGTTCTATAAAGGAAAACGCGTTCATGCAATGGTCGCTCTTACAGAAGAAGGTCTTGAGCCAATTGAACTTGAAGCGAA
AGAAGGTCTGGCGTTAATTAATGGTACGCAGGCGATGACAGCGCAAGGAGTTCTTTCTTATATAGAAGCAGAAGCAACGG
CTTATCAAGCTGAATTCATTGCATCTATGACAATTGAAGGTTTACAAGGCATTATTGATGCATTTGATGAAAATGTTCAT
AAAGCACGTGGTTATAAAGAGCAAGTGGAAGTAGCAAGCAGAATTCGTGACATCCTTCATGATAGTAAATTAACAACGAA
ACAAGGAAAACTACGTGTGCAGGATGCCTATTCACTTCGCTGTATTCCGCAAGTACACGGTGCTTCTTGGCAAGTTTTAA
ATTATGTGAAAGAAAAATTAGAAATTGAAATGAATGCCGCGACAGATAATCCACTTATTTTTGATGGCGGAGAAAAAGTA
ATTTCAGGTGGTAATTTCCACGGTCAACCAATTGCATTTGCGATGGACTTCTTAAAAGTTGGAATGGCAGAACTTGCAAA
TATTTCAGAGCGCCGTATTGAACGCTTAGTAAATCCACAGTTAAACGATTTACCACCATTTTTAAGTCCAGAACCAGGAC
TTCAGTCTGGTGCAATGATTATGCAATATGCTGCAGCGTCACTAGTTTCTGAAAATAAAACGTTAGCACATCCGGCGAGT
GTTGATTCAATCCCGTCATCAGCTAACCAAGAAGATCACGTAAGTATGGGAACAATTGCTTCACGCCATGCACATCAAAT
TATTCAAAATGTAAGACGTGTTCTTTCAATTGAGATGATTTGTGCGATGCAAGCAGCAGAATATCGCGGTATTGAAAACA
TGAGTACAGTGACGAAGAGCTTCTATCATCAAGGTCGTCAACAAGTACCTTCTATTACTAATGACCGTATATTCTCAACG
GATATTGAAAATATTGCGTATTGGTTAAAAACGAATTATTCGATAAAAGAAAGATTAGATGTAAACGCAGCACTATAA

Upstream 100 bases:

>100_bases
CCCATAGTCTATTAGTTAGAAGGGGGCCTTACTTTTTTTAGGACAGAAGTCTGTCTTAAAAAGATAAGGCCCCCTTTTGC
CTTTTTAAGGAGGAAAAAGA

Downstream 100 bases:

>100_bases
AATGAGACAAGGGAGAGATTGAAATGGAAAAAGTTAAACAAACAATTCGCGCGCCAAGAGGTACTGAGTTACAAACGAAA
GGGTGGGTGCAAGAAGCTGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MITLTGHTLTIEEMKRLLLEGEGVTACPNSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLIQ
SHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGE
VFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAEFIASMTIEGLQGIIDAFDENVH
KARGYKEQVEVASRIRDILHDSKLTTKQGKLRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEKV
ISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSITNDRIFST
DIENIAYWLKTNYSIKERLDVNAAL

Sequences:

>Translated_505_residues
MITLTGHTLTIEEMKRLLLEGEGVTACPNSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLIQ
SHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGE
VFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAEFIASMTIEGLQGIIDAFDENVH
KARGYKEQVEVASRIRDILHDSKLTTKQGKLRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEKV
ISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSITNDRIFST
DIENIAYWLKTNYSIKERLDVNAAL
>Mature_505_residues
MITLTGHTLTIEEMKRLLLEGEGVTACPNSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLIQ
SHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGE
VFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAEFIASMTIEGLQGIIDAFDENVH
KARGYKEQVEVASRIRDILHDSKLTTKQGKLRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEKV
ISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIASRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSITNDRIFST
DIENIAYWLKTNYSIKERLDVNAAL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=45.0819672131148, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=42.9718875502008, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55442; Mature: 55442

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLTGHTLTIEEMKRLLLEGEGVTACPNSMQKVAECREVVEKIVEDGKVVYGITTGFGK
CEEECCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
FSDVLIQKDDVKALQHNLIQSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNM
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHCCCCHHHHHHHH
LLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGEVFYKGKRVHAMVALTEEGLE
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCEEEECCEEEEEEEEHHCCCC
PIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAEFIASMTIEGLQGIIDAFDENVH
CEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KARGYKEQVEVASRIRDILHDSKLTTKQGKLRVQDAYSLRCIPQVHGASWQVLNYVKEKL
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHH
EIEMNAATDNPLIFDGGEKVISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQ
EEEEECCCCCCEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSITNDRIFST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECC
DIENIAYWLKTNYSIKERLDVNAAL
CHHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure
MITLTGHTLTIEEMKRLLLEGEGVTACPNSMQKVAECREVVEKIVEDGKVVYGITTGFGK
CEEECCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
FSDVLIQKDDVKALQHNLIQSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNM
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECHHHHCCCCHHHHHHHH
LLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGEVFYKGKRVHAMVALTEEGLE
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHEEEECCCCEEEECCEEEEEEEEHHCCCC
PIELEAKEGLALINGTQAMTAQGVLSYIEAEATAYQAEFIASMTIEGLQGIIDAFDENVH
CEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KARGYKEQVEVASRIRDILHDSKLTTKQGKLRVQDAYSLRCIPQVHGASWQVLNYVKEKL
HHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHH
EIEMNAATDNPLIFDGGEKVISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQ
EEEEECCCCCCEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SRHAHQIIQNVRRVLSIEMICAMQAAEYRGIENMSTVTKSFYHQGRQQVPSITNDRIFST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECC
DIENIAYWLKTNYSIKERLDVNAAL
CHHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA