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The map label for this gene is wecC [H]

Identifier: 49478937

GI number: 49478937

Start: 5002170

End: 5003453

Strand: Reverse

Name: wecC [H]

Synonym: BT9727_4949

Alternate gene names: 49478937

Gene position: 5003453-5002170 (Counterclockwise)

Preceding gene: 49478938

Following gene: 49478936

Centisome position: 95.53

GC content: 33.33

Gene sequence:

>1284_bases
ATGAAGAAAATATGTGTTGTGGGCTTAGGATATATAGGATTACCAACTTGTGCAATGTTTGCCAAGGCTGGATTTAAGGT
CACAGGAGTAGATGTTAATCCTTTAATAATTGATACAGTAAATGATGGGAAAATCCATATCGAAGAAGTTGGATTAGGTG
AATTGGTAAAAGAGGAAGTTTCAAAAGGGAATTTGAATGCAAGTTTAAAACCAGTATTAGCTGATGTATACATTATTGCT
GTTCCTACCCCTCATAATTACGATCATACTGCTGATTTAAAATATGTACAATCTGCAGTAGAATCTATTAAACCATTTTT
ACAAAAAGGGAATATATTAATTGTAGAATCTACTATTCCACCACGTACAATTAATGATATTGTTGCACCAGCAATAGAAG
AGGCTGGTTGGAAAGTCGGAGAAGAAATTTATTTAGCGCATTGTCCAGAACGAGTATTACCTGGAAGGATTCTTATTGAA
TTAGTAGAAAATGCAAGAATAGTTGGGGGAATCAATGAAATCTCAGCTAATAAGGCAGCAGAGATATACAAGAGCTTCGT
AAAAGGGAATGTTATTACAACAACTGCGGTAACTGCAGAAATGGCCAAATTAATGGAAAATACATTTCGAGATGTAAATA
TAGCATTGGCTAATGAGCTAGCTAAAATCTCAGCTAATTTAGGAATTAATGCTTTAGATGTTATTAGTTTAGCTAACTTA
CATCCGAGAGTTAATTTACACACCCCAGGTCCAGGTGTTGGTGGTCACTGTCTAGCGGTTGATCCATACTTTATCATTGA
GAAAGATCCTCAAAATGCCAAATTAATTAGTGATGCTAGAGAAATTAATAATTCTATGCCGAATTTTGTAGTTGAGAATG
TGGGTAAACTATTAGGAGAAGGACGCGGTAAAATCACCGTTATGGGTCTAACTTATAAAGGGAATATAGATGATGTACGT
GAAAGTCCAGCTATGGAAATAGTAGAATTACTACGAAAAGAAGGCTATGAGGTGGCAGTTTACGATCCGCATGTAGTACA
AGAAGCAGTTCCTTATGAATTAAAAACGTTTAAAGAGGCAGTTGATAAAACACAATGTATATTAGTTTTATCAGACCATA
ATGAATTTAAAAATTTAGATGAGGAAACTATAATTAAAAGAGCAGAAAGACCAATAATTTTCGATACTAGAAATTGCGTG
CAGGTAAATAATAAAGCTATTTTATATTACAATTATAATAACCTACACGAAGCTATCAATAATTTAGTTTTTAAAAATAT
TTAG

Upstream 100 bases:

>100_bases
ATGCATTTGATTATGCGTCTAATTATTTATCTTATGAAAAAGCGTTTAATACATTTATGAATATATATAGTGAAACACAA
ACGATTAGGAGGAAATAATT

Downstream 100 bases:

>100_bases
TAATGAAACAATTGTTAGGTGGCAGATATAAATGAATGTTTATAAATGGTATAAAGTATCAAGAGTACTTTACGAATGGA
AAATTCCTTTTATCCCTGGT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: GDP-D-mannuronate; NADH; H+

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKKICVVGLGYIGLPTCAMFAKAGFKVTGVDVNPLIIDTVNDGKIHIEEVGLGELVKEEVSKGNLNASLKPVLADVYIIA
VPTPHNYDHTADLKYVQSAVESIKPFLQKGNILIVESTIPPRTINDIVAPAIEEAGWKVGEEIYLAHCPERVLPGRILIE
LVENARIVGGINEISANKAAEIYKSFVKGNVITTTAVTAEMAKLMENTFRDVNIALANELAKISANLGINALDVISLANL
HPRVNLHTPGPGVGGHCLAVDPYFIIEKDPQNAKLISDAREINNSMPNFVVENVGKLLGEGRGKITVMGLTYKGNIDDVR
ESPAMEIVELLRKEGYEVAVYDPHVVQEAVPYELKTFKEAVDKTQCILVLSDHNEFKNLDEETIIKRAERPIIFDTRNCV
QVNNKAILYYNYNNLHEAINNLVFKNI

Sequences:

>Translated_427_residues
MKKICVVGLGYIGLPTCAMFAKAGFKVTGVDVNPLIIDTVNDGKIHIEEVGLGELVKEEVSKGNLNASLKPVLADVYIIA
VPTPHNYDHTADLKYVQSAVESIKPFLQKGNILIVESTIPPRTINDIVAPAIEEAGWKVGEEIYLAHCPERVLPGRILIE
LVENARIVGGINEISANKAAEIYKSFVKGNVITTTAVTAEMAKLMENTFRDVNIALANELAKISANLGINALDVISLANL
HPRVNLHTPGPGVGGHCLAVDPYFIIEKDPQNAKLISDAREINNSMPNFVVENVGKLLGEGRGKITVMGLTYKGNIDDVR
ESPAMEIVELLRKEGYEVAVYDPHVVQEAVPYELKTFKEAVDKTQCILVLSDHNEFKNLDEETIIKRAERPIIFDTRNCV
QVNNKAILYYNYNNLHEAINNLVFKNI
>Mature_427_residues
MKKICVVGLGYIGLPTCAMFAKAGFKVTGVDVNPLIIDTVNDGKIHIEEVGLGELVKEEVSKGNLNASLKPVLADVYIIA
VPTPHNYDHTADLKYVQSAVESIKPFLQKGNILIVESTIPPRTINDIVAPAIEEAGWKVGEEIYLAHCPERVLPGRILIE
LVENARIVGGINEISANKAAEIYKSFVKGNVITTTAVTAEMAKLMENTFRDVNIALANELAKISANLGINALDVISLANL
HPRVNLHTPGPGVGGHCLAVDPYFIIEKDPQNAKLISDAREINNSMPNFVVENVGKLLGEGRGKITVMGLTYKGNIDDVR
ESPAMEIVELLRKEGYEVAVYDPHVVQEAVPYELKTFKEAVDKTQCILVLSDHNEFKNLDEETIIKRAERPIIFDTRNCV
QVNNKAILYYNYNNLHEAINNLVFKNI

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=443, Percent_Identity=26.410835214447, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI296040443, Length=432, Percent_Identity=25.462962962963, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI296040438, Length=344, Percent_Identity=23.8372093023256, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI48994968, Length=404, Percent_Identity=45.2970297029703, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1788340, Length=381, Percent_Identity=26.246719160105, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560350, Length=439, Percent_Identity=26.6514806378132, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136908, Length=444, Percent_Identity=27.2522522522523, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.132

Molecular weight: Translated: 46969; Mature: 46969

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKICVVGLGYIGLPTCAMFAKAGFKVTGVDVNPLIIDTVNDGKIHIEEVGLGELVKEEV
CCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHH
SKGNLNASLKPVLADVYIIAVPTPHNYDHTADLKYVQSAVESIKPFLQKGNILIVESTIP
HCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PRTINDIVAPAIEEAGWKVGEEIYLAHCPERVLPGRILIELVENARIVGGINEISANKAA
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCHHHHHHHHHCCEEECCCHHHCCHHHH
EIYKSFVKGNVITTTAVTAEMAKLMENTFRDVNIALANELAKISANLGINALDVISLANL
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
HPRVNLHTPGPGVGGHCLAVDPYFIIEKDPQNAKLISDAREINNSMPNFVVENVGKLLGE
CCEEEEECCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHC
GRGKITVMGLTYKGNIDDVRESPAMEIVELLRKEGYEVAVYDPHVVQEAVPYELKTFKEA
CCCEEEEEEEEEECCHHHHHCCHHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHH
VDKTQCILVLSDHNEFKNLDEETIIKRAERPIIFDTRNCVQVNNKAILYYNYNNLHEAIN
CCCCEEEEEEECCHHHHCCCHHHHHHHCCCCEEEECCCEEEECCCEEEEECCHHHHHHHH
NLVFKNI
HHHHCCC
>Mature Secondary Structure
MKKICVVGLGYIGLPTCAMFAKAGFKVTGVDVNPLIIDTVNDGKIHIEEVGLGELVKEEV
CCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCEEEEEECCHHHHHHHHH
SKGNLNASLKPVLADVYIIAVPTPHNYDHTADLKYVQSAVESIKPFLQKGNILIVESTIP
HCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PRTINDIVAPAIEEAGWKVGEEIYLAHCPERVLPGRILIELVENARIVGGINEISANKAA
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHCCHHHHHHHHHCCEEECCCHHHCCHHHH
EIYKSFVKGNVITTTAVTAEMAKLMENTFRDVNIALANELAKISANLGINALDVISLANL
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
HPRVNLHTPGPGVGGHCLAVDPYFIIEKDPQNAKLISDAREINNSMPNFVVENVGKLLGE
CCEEEEECCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHC
GRGKITVMGLTYKGNIDDVRESPAMEIVELLRKEGYEVAVYDPHVVQEAVPYELKTFKEA
CCCEEEEEEEEEECCHHHHHCCHHHHHHHHHHHCCCEEEEECCHHHHHHCCHHHHHHHHH
VDKTQCILVLSDHNEFKNLDEETIIKRAERPIIFDTRNCVQVNNKAILYYNYNNLHEAIN
CCCCEEEEEEECCHHHHCCCHHHHHHHCCCCEEEECCCEEEECCCEEEEECCHHHHHHHH
NLVFKNI
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-D-mannose; NAD+; H2O

Specific reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA