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The map label for this gene is hemD

Identifier: 49478645

GI number: 49478645

Start: 4260611

End: 4261363

Strand: Reverse

Name: hemD

Synonym: BT9727_4196

Alternate gene names: 49478645

Gene position: 4261363-4260611 (Counterclockwise)

Preceding gene: 49478646

Following gene: 49478644

Centisome position: 81.36

GC content: 39.18

Gene sequence:

>753_bases
ATGAACGCTCTCGCTGGCAAAACGGTATTGATTACACGTGCCCAGCACCAAGCAAAACAAATGAGTGTAGCGGTGAAAGA
AAAGAGCGGAATTCCATTGGAAATTCCGCTTTTGCGTATGGAGGGTATGTCTCATAGGCAAATTCAACATATAGCAGGGC
AGCTACATTCGTATGACTGGGTTATTTTTACGAGTAAAAATGGGGTAGCTTTTTTTCTAGATTATTTGAGAAAGAAGCTC
CCCGTAACGACTAAAATTGCTGCAGTAGGCGTGAAAACAAAGTTAGAGTTAGAAAAGCGAGGCTATGAAGTGGACTTCGT
TCCAACTTCATTTGTTGCAGAAGTATTTGCAGAAGAGTTTGTAAAAAGACTAAGTGGAAACGAATGCATTTTATTTCCGA
AAGGGAATTTAGCAAGAGATGTCATTCCAGTTGCGCTTCGCGAAATCGGTGTTTCTCTAGATGAGCTCATCGTATATGGT
ACGAAAGAAAATGTAGAGAAAAAGAGAGAGCTTATAGAAGCGTTAGAAGTAGGGAAAGTAGACATTATTACATTTACGAG
CCCTTCAACTGTTACTAGTTTTGTTCGTTTACTTGAGGGTACAAACTGGAGAGAATGGACAAAAAAATGTACAATTGCTT
GTATAGGGCCTATTACGGAAAAAGAGGCGAGCCTTTATTTTCCGCATGTTATTATGCCGAAAGAGTACACTGTAGAAGCA
TTACTACAATGCGTTTGTGAATCTATAAAATAA

Upstream 100 bases:

>100_bases
GAACTGATCCAGAGAAAGTAGGATTAGAGGCTGCGGACCGTTTAATTAAACAAGGCGCAAAAGAACTCATTCTTGCTGCA
AATAAGGGGCAACAATAAAT

Downstream 100 bases:

>100_bases
AAGAATGGGGATAGAAATCTATGAACTCTTTACAATTTAATCGTCATCGTCGCTTAAGACAAAGCGGGGGCATGCGTGCG
CTTGTGCGTGAAACGTTTTT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDYLRKKL
PVTTKIAAVGVKTKLELEKRGYEVDFVPTSFVAEVFAEEFVKRLSGNECILFPKGNLARDVIPVALREIGVSLDELIVYG
TKENVEKKRELIEALEVGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Sequences:

>Translated_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDYLRKKL
PVTTKIAAVGVKTKLELEKRGYEVDFVPTSFVAEVFAEEFVKRLSGNECILFPKGNLARDVIPVALREIGVSLDELIVYG
TKENVEKKRELIEALEVGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK
>Mature_250_residues
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDWVIFTSKNGVAFFLDYLRKKL
PVTTKIAAVGVKTKLELEKRGYEVDFVPTSFVAEVFAEEFVKRLSGNECILFPKGNLARDVIPVALREIGVSLDELIVYG
TKENVEKKRELIEALEVGKVDIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
LLQCVCESIK

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28114; Mature: 28114

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHHEEECCCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDYLRKKLPVTTKIAAVGVKTKLELEKRGYEVDFVPTSFVAEVFAEEF
EEEECCCCHHHHHHHHHHHCCCHHHHEEECCCCEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNECILFPKGNLARDVIPVALREIGVSLDELIVYGTKENVEKKRELIEALEVGKV
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCHHHHH
LLQCVCESIK
HHHHHHHHCC
>Mature Secondary Structure
MNALAGKTVLITRAQHQAKQMSVAVKEKSGIPLEIPLLRMEGMSHRQIQHIAGQLHSYDW
CCCCCCCEEEEECCHHHHHHHHHEEECCCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCEE
VIFTSKNGVAFFLDYLRKKLPVTTKIAAVGVKTKLELEKRGYEVDFVPTSFVAEVFAEEF
EEEECCCCHHHHHHHHHHHCCCHHHHEEECCCCEEEHHHCCCEEEECCHHHHHHHHHHHH
VKRLSGNECILFPKGNLARDVIPVALREIGVSLDELIVYGTKENVEKKRELIEALEVGKV
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCHHHHHHHHHHHHHHHCCCE
DIITFTSPSTVTSFVRLLEGTNWREWTKKCTIACIGPITEKEASLYFPHVIMPKEYTVEA
EEEEECCCHHHHHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCEECCEEECCCCHHHHH
LLQCVCESIK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]