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The map label for this gene is nadC

Identifier: 49478633

GI number: 49478633

Start: 4226058

End: 4226891

Strand: Reverse

Name: nadC

Synonym: BT9727_4163

Alternate gene names: 49478633

Gene position: 4226891-4226058 (Counterclockwise)

Preceding gene: 49481520

Following gene: 49478632

Centisome position: 80.7

GC content: 39.45

Gene sequence:

>834_bases
ATGAATACGATAAAGGTTAAAGAAGCATTAAATCGATTTTTTCTAGAAGATATAGGAGAAAGAGATGTAACATCTCAGCT
TATTTTTCCAGACAATCTACTTTCAAAAGGAACGTTTCTTGCGAAAGATACCGGGGTCTTTACGGGACGTTTAGTCATAG
AAGAAGGGTTTAAATTAATTGATGAGAGAATTAAAGTGGAGCTTCATAAAAAAGATGGAGATCTTCTAGAAAAAGGCGAA
ATAATCGCAACAGTGCAAGGGCCAATTGCTTCGTTATTAACGGCAGAGCGCGTTATATTAAACGTTATCCAGCGTATGAG
CGGAATAGCGACGATGACGCGTAAAGCGGTTCTCGCTTTAGATAGCAGCCATACACGCATTTGTGATACGCGAAAAACGA
TGCCAGGGCTACGTATGTTTGATAAGTATGCAGTTGTATGCGGAGGCGGATTTAATCACCGTTTCGGCTTATATGATGGT
GTCATGATCAAAGACAATCATATTGCTTTTGCTGGCTCTATTACGAAAGCTGTTACATCGGTAAAAGAAAAATTAGGGCA
TATGGTGAAAGTAGAAGTGGAAACAGAAACGGAGGAACAAGTGAGAGAGGCCGTAGCTGCTGGTGCGGATATTATTATGT
TCGATAACCGTACGCCAGATGAGATTCGAGAGTTTTCAAAGATTGTCCCAAGTGCCATCGTTACAGAAGCTTCAGGAGGC
ATTACAATTAAAGATTTATCGAAATACGGAAAAACAGGGGTAGATTATATTTCACTTGGAGCGTTAACACATTCAGTGAA
AGCACTTGATATTAGTTTTAATATTGAGGCGTAA

Upstream 100 bases:

>100_bases
CATTATCGAAGTGATTATCCACATAGAAATAGCGCACAAAAAGAGATCATTCGAGTGAAAAGAAAACTACAACTTGTGTA
ATGAGGGGAAGAGGGGTTTT

Downstream 100 bases:

>100_bases
GGAAAGTGGCTTAGAGGGGGAGAAAGAAATATGAGTATTTTAGAAAAAGTACAACCGATTGAAACGATGTTACCAGAGCG
TTATTACACGATGTCAACAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFTGRLVIEEGFKLIDERIKVELHKKDGDLLEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGADIIMFDNRTPDEIREFSKIVPSAIVTEASGG
ITIKDLSKYGKTGVDYISLGALTHSVKALDISFNIEA

Sequences:

>Translated_277_residues
MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFTGRLVIEEGFKLIDERIKVELHKKDGDLLEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGADIIMFDNRTPDEIREFSKIVPSAIVTEASGG
ITIKDLSKYGKTGVDYISLGALTHSVKALDISFNIEA
>Mature_277_residues
MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFTGRLVIEEGFKLIDERIKVELHKKDGDLLEKGE
IIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLALDSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDG
VMIKDNHIAFAGSITKAVTSVKEKLGHMVKVEVETETEEQVREAVAAGADIIMFDNRTPDEIREFSKIVPSAIVTEASGG
ITIKDLSKYGKTGVDYISLGALTHSVKALDISFNIEA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=249, Percent_Identity=35.7429718875502, Blast_Score=147, Evalue=8e-36,
Organism=Escherichia coli, GI1786299, Length=277, Percent_Identity=41.1552346570397, Blast_Score=191, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6321162, Length=283, Percent_Identity=31.8021201413428, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30423; Mature: 30423

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFTGRLVIEEGFKLI
CCCCHHHHHHHHHHHHHCCCCCCHHEEECCCHHHCCCCEEEECCCCEEEHHHHHHHHHHH
DERIKVELHKKDGDLLEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLAL
HHHHEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAVTS
CCCCCEEHHHHHCCCCHHHHHCEEEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHH
VKEKLGHMVKVEVETETEEQVREAVAAGADIIMFDNRTPDEIREFSKIVPSAIVTEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHEECCCCC
ITIKDLSKYGKTGVDYISLGALTHSVKALDISFNIEA
EEHHHHHHCCCCCCCEEEHHHHHHCEEEEEEEEEECC
>Mature Secondary Structure
MNTIKVKEALNRFFLEDIGERDVTSQLIFPDNLLSKGTFLAKDTGVFTGRLVIEEGFKLI
CCCCHHHHHHHHHHHHHCCCCCCHHEEECCCHHHCCCCEEEECCCCEEEHHHHHHHHHHH
DERIKVELHKKDGDLLEKGEIIATVQGPIASLLTAERVILNVIQRMSGIATMTRKAVLAL
HHHHEEEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
DSSHTRICDTRKTMPGLRMFDKYAVVCGGGFNHRFGLYDGVMIKDNHIAFAGSITKAVTS
CCCCCEEHHHHHCCCCHHHHHCEEEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHH
VKEKLGHMVKVEVETETEEQVREAVAAGADIIMFDNRTPDEIREFSKIVPSAIVTEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCHHHEECCCCC
ITIKDLSKYGKTGVDYISLGALTHSVKALDISFNIEA
EEHHHHHHCCCCCCCEEEHHHHHHCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]