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The map label for this gene is zwf

Identifier: 49478204

GI number: 49478204

Start: 3235101

End: 3236585

Strand: Reverse

Name: zwf

Synonym: BT9727_3166

Alternate gene names: 49478204

Gene position: 3236585-3235101 (Counterclockwise)

Preceding gene: 49479497

Following gene: 49478203

Centisome position: 61.79

GC content: 37.78

Gene sequence:

>1485_bases
TTGGAATCAATGACCTTTGTTTTATTTGGAGCGACAGGGGACTTAGCGAAACGCAAAATTTACCCCGCACTATATAACTT
ATATAGAGATCAAAAGCTTCCAAAGCAAATATCCGTTATCGGGCTTGGGAGACGTGAAGTATCTCATGTAGATTTCCAAA
AAAGAATAAAAGAATCAATAGAGACGTTTTCTCGTCATAGAGAAGAAGGTACTCCAGAACTCGAAGATTTTTTAGATAAT
TTTCGCTATTGTCCATTAGATGTGAGTAAGCCGGAAGACTATGAGAGATTATTACAAGTCGTTCGTGAAAGGGAAGAAGA
GCTACATATAAAAGGGAATAGAATGTTCTATCTTTCTGTTGCTCCTGAATTTTTTGAGACAATCGCTTTAAATATTAAGG
AAAGCGGACTTGATAAAACGGATGGATGGAAACGCCTAATGATTGAGAAACCGTTCGGGCACGATCTTACATCTGCTCGT
GAGCTGAATGATAAGCTTAGTCGCACGTTTGAAGAAGACGAGATATACCGTATTGATCATTATTTAGGTAAGCCGATGAT
TCAAAACCTTGAAGCACTAGAGTTTGCAAATCCTGTTTTACAATCGATTTGGAATAAAGAACATATAGCGAATGTACAAA
TCACAGCGAGTGAAACAGTTGGGGTTGAAGAAAGGGCAGGATATTATGATCAGGCAGGAGCCATTCGAGATATGGTTCAA
AATCATATGTTACAAATATTAATGATGACTGCTATGAATTTGCCGGAAAAGGTTAATGCATGTGAAATTCGAGAGGAAAA
GCGAAAGGTAATGGAGGCGCTTCGTAAAGTGAAAAAAGAAGACGTTCAAAACCATATCATTCGCGGACAATATGGTGCAG
GTGAGATAAATGGCGGGCAAGTTGTAGCATATAAAGAGGAGCCAGGAGTAAATCCTTCTTCTAATATAGACACATTTGTT
GCTGCTCGCTTGTGGATCGATAATCCATTTTGGACTGGCGTTCCCTTTTATATACGAACAGGCAAACGAATGAAAGAAAA
GTCTACTCGTATTGTAATCGAATTTAAAAATACGTTAAAACAGCAATATCAAGATAGTAATCCAAATGCAGCACCTAACT
TGTTAATAATTGAAATTAGCCCAGGTGAGAACGTTTCATTACAGTTAAATAGTAAAAATCCATTGAAAAATGGAGAAATT
GAACCGATCCGTATTAACTTTACTTGTGAGCAAGCGGATGTGGGAGTACCTGAAGCGTATGAAAGACTCATTCATGATGC
TGTGAGTGGAGACGCTACATTCTTTGCACATTGGAGAGAAGTTGAATTGTCATGGGAATGGGTACAACCAATTCTTGAAG
CATTCGAGGAAAACTTATTACCACTTCATGAATATGAGTCTGGTTCACATGGTCCAGAGGCATCTAATGAATTATTGCAA
GAAAGTGGATTTAAATGGTGGTTAGATCAAGAAACGAAAAAATAA

Upstream 100 bases:

>100_bases
TGGAATTTGATAACTCTTTGTTTTTTATAAAAACATGAGCTTCTGTACAATTCATTTTTAATATATTGACCAGGATTATA
CAACAAGAGGGGGACTGAAA

Downstream 100 bases:

>100_bases
GTACTTTCTTTCATGAAAGCATGTAGGGGGACGATTACTATGACACAAAACATAAATCAATTAGCAGTGAATACAATTCG
TACGTTATCAATTGACGCTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTPELEDFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMEALRKVKKEDVQNHIIRGQYGAGEINGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPIRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWREVELSWEWVQPILEAFEENLLPLHEYESGSHGPEASNELLQ
ESGFKWWLDQETKK

Sequences:

>Translated_494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTPELEDFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMEALRKVKKEDVQNHIIRGQYGAGEINGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPIRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWREVELSWEWVQPILEAFEENLLPLHEYESGSHGPEASNELLQ
ESGFKWWLDQETKK
>Mature_494_residues
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESIETFSRHREEGTPELEDFLDN
FRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSVAPEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSAR
ELNDKLSRTFEEDEIYRIDHYLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
NHMLQILMMTAMNLPEKVNACEIREEKRKVMEALRKVKKEDVQNHIIRGQYGAGEINGGQVVAYKEEPGVNPSSNIDTFV
AARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLKQQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEI
EPIRINFTCEQADVGVPEAYERLIHDAVSGDATFFAHWREVELSWEWVQPILEAFEENLLPLHEYESGSHGPEASNELLQ
ESGFKWWLDQETKK

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=491, Percent_Identity=35.6415478615071, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=35.6415478615071, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI52145310, Length=479, Percent_Identity=29.8538622129436, Blast_Score=188, Evalue=9e-48,
Organism=Escherichia coli, GI1788158, Length=493, Percent_Identity=37.525354969574, Blast_Score=332, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=37.1134020618557, Blast_Score=331, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=36.0995850622407, Blast_Score=293, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24643350, Length=487, Percent_Identity=37.3716632443532, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643352, Length=487, Percent_Identity=37.3716632443532, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI221513548, Length=498, Percent_Identity=29.5180722891566, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57156; Mature: 57156

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESI
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ETFSRHREEGTPELEDFLDNFRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSV
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
APEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSARELNDKLSRTFEEDEIYRIDH
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHH
YLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
NHMLQILMMTAMNLPEKVNACEIREEKRKVMEALRKVKKEDVQNHIIRGQYGAGEINGGQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VVAYKEEPGVNPSSNIDTFVAARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLK
EEEECCCCCCCCCCCCHHHHEEHEEECCCCCCCCCCEEECCCHHHCCCCEEEEEEHHHHH
QQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEIEPIRINFTCEQADVGVPEAY
HHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCHHH
ERLIHDAVSGDATFFAHWREVELSWEWVQPILEAFEENLLPLHEYESGSHGPEASNELLQ
HHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
ESGFKWWLDQETKK
HCCCEEECCCCCCC
>Mature Secondary Structure
MESMTFVLFGATGDLAKRKIYPALYNLYRDQKLPKQISVIGLGRREVSHVDFQKRIKESI
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
ETFSRHREEGTPELEDFLDNFRYCPLDVSKPEDYERLLQVVREREEELHIKGNRMFYLSV
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEE
APEFFETIALNIKESGLDKTDGWKRLMIEKPFGHDLTSARELNDKLSRTFEEDEIYRIDH
CHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHH
YLGKPMIQNLEALEFANPVLQSIWNKEHIANVQITASETVGVEERAGYYDQAGAIRDMVQ
HHCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
NHMLQILMMTAMNLPEKVNACEIREEKRKVMEALRKVKKEDVQNHIIRGQYGAGEINGGQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VVAYKEEPGVNPSSNIDTFVAARLWIDNPFWTGVPFYIRTGKRMKEKSTRIVIEFKNTLK
EEEECCCCCCCCCCCCHHHHEEHEEECCCCCCCCCCEEECCCHHHCCCCEEEEEEHHHHH
QQYQDSNPNAAPNLLIIEISPGENVSLQLNSKNPLKNGEIEPIRINFTCEQADVGVPEAY
HHHCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCHHH
ERLIHDAVSGDATFFAHWREVELSWEWVQPILEAFEENLLPLHEYESGSHGPEASNELLQ
HHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
ESGFKWWLDQETKK
HCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]