Click here to switch to the map view.

The map label for this gene is tkt

Identifier: 49478203

GI number: 49478203

Start: 3233067

End: 3235061

Strand: Reverse

Name: tkt

Synonym: BT9727_3165

Alternate gene names: 49478203

Gene position: 3235061-3233067 (Counterclockwise)

Preceding gene: 49478204

Following gene: 49478202

Centisome position: 61.77

GC content: 39.95

Gene sequence:

>1995_bases
ATGACACAAAACATAAATCAATTAGCAGTGAATACAATTCGTACGTTATCAATTGACGCTATTAATGCGGCAAATTCAGG
TCATCCAGGTCTTCCGATGGGAGCAGCGCCAATGGCTTATGCATTATGGGCGAATCATTTAAATCATAATCCTAATCATC
CAAAATGGTTTAACCGTGATCGCTTCGTTTTATCGGCGGGACATGGATCTAGCTTATTATATAGCCTACTTCATTTAGCT
GGATATGACGTTTCAATTGATGACTTGAAAAACTTCAGAAAGTTAAATAGTAAGACACCAGGACATCCTGAGTTTGGTCA
TACTTCTGGAGTTGAAGCGACGACAGGCCCGTTAGGACAAGGGATTGCCAATGCTGTCGGAATGGCAATGGCAGAAGCGC
ATTTAGCAGCGAAGTTTAATAAGGATGGTCACTCTATTATAGATCACAATACGTACGCTTTAGTCGGAGACGGTGATTTA
ATGGAAGGTGTCGCTTATGAAGCGATGTCAATGGCAGGACATATGAAACTTGGCAAGTTAATTGTGCTGTATGATTCAAA
TGAAATTTCACTTGATGGTGAATTAAACATTGCTTTCTCTGAAGATATGCAGAAAAGGGTAGAATCTGCACATTGGCAAT
ATGTAAGAGTTGAAGATGGAAACGATGTTGATGCGATTACAAAAGCGATTCAATTAGCGAAAGATAATACGGACCAACCT
ACTCTTATAGAGATTAGAACCGTTATAGGTTACGGAAGTCCAAAAGTTGCTGGAACGAACAAAGCACATGGTAACCCGCT
TGGAGTAGAAGAAGCGACAGCGACAAAACAAGTGTATGGTTGGCATTATGAAGAAGACTTCTTTGTACCTGAAGAAGTAA
CAGCTCATTTTAATGAACTGAAACAAAAAGGTATTGAAAAAGAACGTGGCTGGAATGAGCAGTTCAACTTATACAGAGAG
TCAAATCCTGCACTAGCAGATGAATTAGAAAAAGCAATTACAGGTGAAGTTTTAATCGAAGCGAAAGACATTTTATCCTT
CGATACTGAAAAAACGATTTCAACTCGTGTTGCAAGTGGGGAAGCTATTAATCATTATGTGAAATCGATTCCTTCTATTT
TCGGTGGAAGTGCAGATCTTTCTCATTCTACGATGACAGATATAAAAGGTGAAGCAGTGTATGCGGTAGAATCGTATGCT
GGCCGAAATATATACTTTGGTGTACGTGAACATGCAATGGGCGCAGCAGCGAATGGACTGGCTCTTCATGGAGGAGTAAA
ACCGTTTGTGAGTACATTCTTTGTATTTAATGACTATCTTCGTCCATCTATTCGACTGGCTGCATTGCAAAAGTTACCTG
TTACGTACGTATTTACACATGATTCAATTGCTGTAGGAGAAGATGGTCCAACGCATGAACCTATTGAACATTTAGCAGCT
CTTCGGGCAATCCCTGGTTTAACAGTTATCCGTCCGTCAGATGCAAATGAAACAGCAAGTGCGTGGGCGTATGCTTTACA
GCAAACGGATGGTCCAGTCGTTTTAGTACTTAGCCGTCAAAATTTACCGGTGTTTCATGAAACGAAAGCAAACATAGAGA
ATCTTTCTAAAGGGGCTTACGTATTAACACAAACGAATGAAAATCCGGATGTAATTTTAATTGCGACAGGTTCTGAAGTA
TCCTTAGCTGCTAGTGCGAAAGCGAAACTAGAAGAAGACAATGTCTCTGTTCGCATCGTTGCAATGCCAAGCTGGGAGTT
ATTCGATCGCCAATCGAAAGAATATAAAGAATCCGTTCTTCCGTCTTCTGTAACGAAACGAGTATCTCTTGAGATGGGTG
TATCTCTCGGCTGGGAGCGTTATGTAGGACAAGAAGGAAACATATTATCGATTGAAACATTTGGAGCTTCAGGAACTGGG
GCTGAAGTCATGAATCTATTTGGATTTACGACAGAAAATGTTGTTCAAATTACAAAAAATGTATTAAATTCTTAA

Upstream 100 bases:

>100_bases
TAATGAATTATTGCAAGAAAGTGGATTTAAATGGTGGTTAGATCAAGAAACGAAAAAATAAGTACTTTCTTTCATGAAAG
CATGTAGGGGGACGATTACT

Downstream 100 bases:

>100_bases
GCTATGACTGTGAATACCTTTCCGTACATATCAGTGCTGCAAGGTATTCCAGATTGTAGTGATATGAATTTTTAATAAAA
GATGATTTGAGGAGGAATTA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLA
GYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDL
MEGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQLAKDNTDQP
TLIEIRTVIGYGSPKVAGTNKAHGNPLGVEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERGWNEQFNLYRE
SNPALADELEKAITGEVLIEAKDILSFDTEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYA
GRNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPTHEPIEHLAA
LRAIPGLTVIRPSDANETASAWAYALQQTDGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPDVILIATGSEV
SLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTG
AEVMNLFGFTTENVVQITKNVLNS

Sequences:

>Translated_664_residues
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLA
GYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDL
MEGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQLAKDNTDQP
TLIEIRTVIGYGSPKVAGTNKAHGNPLGVEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERGWNEQFNLYRE
SNPALADELEKAITGEVLIEAKDILSFDTEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYA
GRNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPTHEPIEHLAA
LRAIPGLTVIRPSDANETASAWAYALQQTDGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPDVILIATGSEV
SLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTG
AEVMNLFGFTTENVVQITKNVLNS
>Mature_663_residues
TQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLAG
YDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLM
EGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQLAKDNTDQPT
LIEIRTVIGYGSPKVAGTNKAHGNPLGVEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERGWNEQFNLYRES
NPALADELEKAITGEVLIEAKDILSFDTEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYAG
RNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPTHEPIEHLAAL
RAIPGLTVIRPSDANETASAWAYALQQTDGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPDVILIATGSEVS
LAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTGA
EVMNLFGFTTENVVQITKNVLNS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=670, Percent_Identity=26.4179104477612, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4507521, Length=670, Percent_Identity=26.4179104477612, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI133778974, Length=662, Percent_Identity=25.6797583081571, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI225637459, Length=680, Percent_Identity=22.0588235294118, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI225637463, Length=594, Percent_Identity=22.2222222222222, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI225637461, Length=596, Percent_Identity=22.4832214765101, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI48994911, Length=658, Percent_Identity=48.1762917933131, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=47.4474474474475, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=660, Percent_Identity=25.4545454545455, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=674, Percent_Identity=46.2908011869436, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=44.3452380952381, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=581, Percent_Identity=29.4320137693632, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI45550715, Length=581, Percent_Identity=29.4320137693632, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24645119, Length=542, Percent_Identity=29.1512915129151, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=27.8350515463918, Blast_Score=186, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72222; Mature: 72091

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRD
CCCCHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RFVLSAGHGSSLLYSLLHLAGYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
GIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLMEGVAYEAMSMAGHMKLGKL
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHCCEEECCE
IVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQLAKDNTDQP
EEEECCCEEEECCEEEEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
TLIEIRTVIGYGSPKVAGTNKAHGNPLGVEEATATKQVYGWHYEEDFFVPEEVTAHFNEL
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
KQKGIEKERGWNEQFNLYRESNPALADELEKAITGEVLIEAKDILSFDTEKTISTRVASG
HHHCCHHHCCCCCHHCEEECCCCCHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHCCC
EAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYAGRNIYFGVREHAMGAAANGL
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEEEEHHHHCCCCCCCE
ALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPTHEPIEHLAA
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHH
LRAIPGLTVIRPSDANETASAWAYALQQTDGPVVLVLSRQNLPVFHETKANIENLSKGAY
HHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCHHHCCCCEE
VLTQTNENPDVILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVL
EEEECCCCCCEEEEECCCCEEEEECCHHEECCCCEEEEEEEECCHHHHHHHHHHHHHHCC
PSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTGAEVMNLFGFTTENVVQITKN
CHHHHHHEEEECCCCCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
VLNS
HHCC
>Mature Secondary Structure 
TQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRD
CCCHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RFVLSAGHGSSLLYSLLHLAGYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
GIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLMEGVAYEAMSMAGHMKLGKL
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHCCEEECCE
IVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQLAKDNTDQP
EEEECCCEEEECCEEEEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
TLIEIRTVIGYGSPKVAGTNKAHGNPLGVEEATATKQVYGWHYEEDFFVPEEVTAHFNEL
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
KQKGIEKERGWNEQFNLYRESNPALADELEKAITGEVLIEAKDILSFDTEKTISTRVASG
HHHCCHHHCCCCCHHCEEECCCCCHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHCCC
EAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYAGRNIYFGVREHAMGAAANGL
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEEEEHHHHCCCCCCCE
ALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPTHEPIEHLAA
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHH
LRAIPGLTVIRPSDANETASAWAYALQQTDGPVVLVLSRQNLPVFHETKANIENLSKGAY
HHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCHHHCCCCEE
VLTQTNENPDVILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVL
EEEECCCCCCEEEEECCCCEEEEECCHHEECCCCEEEEEEEECCHHHHHHHHHHHHHHCC
PSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTGAEVMNLFGFTTENVVQITKN
CHHHHHHEEEECCCCCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
VLNS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]