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The map label for this gene is sucD [H]

Identifier: 49476304

GI number: 49476304

Start: 1912262

End: 1913164

Strand: Reverse

Name: sucD [H]

Synonym: BH16550

Alternate gene names: 49476304

Gene position: 1913164-1912262 (Counterclockwise)

Preceding gene: 49476305

Following gene: 49476303

Centisome position: 99.07

GC content: 42.19

Gene sequence:

>903_bases
ATGTCAATTCTTGTGAATAAAGATACGAAAGTTCTCGTTCAAGGGCTTACAGGAAAAACAGGAACTTTTCATACAGAACA
AGCGCTTGCTTATCATGGTACCCAAATGGTTGGCGGCGTTAATCCTAAAAAGGGTGGTGAGACATGGGAGGGTTCAAAAG
GTGAAACTCTTCCTATTTTTGCTAGTGTTGCGGAAGGAAAAGAAAAAACAGGTGCAGATGCTTCCGTTATTTATGTTCCT
CCTGCAGGGGCAGCAGCAGCTATTATAGAGGCTGTTGAAGCTGAAATCCGTTTAATTATCTGTATTACGGAAGGCATTCC
TGTTATGGATATGGTGAAAGTAAAAGCGAGATTAGAAAAATCAAAATCACGTCTCATTGGTCCTAATTGTCCTGGCATTC
TCACACCAAATGAATGTAAAATCGGTATTATGCCTGGTTCTATTTTTAGAAAAGGCTCTGTTGGGGTTGTCTCACGGTCG
GGAACTTTGACTTATGAAGCCGTCTTTCAAACCAGTCATGAAGGTCTTGGACAGACAACAGCTATTGGTATTGGCGGCGA
TCCTGTTAAGGGCACTGAATTTATTGATGTGTTAGAAATGTTTTTAGCAGATGATGAAACTCAATCTATTGTTATGATTG
GTGAGATTGGTGGTTCTGCCGAAGAAGAAGCAGCACAGTTTCTCCAAGATGAGGCAAAAAAAGGCCGTAAAAAGCCGGTG
GTTGGTTTTATTGCTGGTCGTACAGCTCCTCCAGGACGCACAATGGGGCATGCGGGTGCTGTTATTTCTGGTGGAAAAGG
TGGTGCAGAAGATAAAATCGCAGCAATGGAATCAGCAGGAATTAAAGTTTCTCCTTCACCCTCACAGATAGGAAAGACAT
TGATGTCAGTTTTGAAGGGATAA

Upstream 100 bases:

>100_bases
GAAAGCGATTATCAGTGATAGTGGTCTGAACGTTATTCCTGCTGATGATTTAGATGATGCTGCTCAAAAAATTGTTGCAG
CCGTGAAGGGAGCTTAAGCT

Downstream 100 bases:

>100_bases
AAGAAAACTTTATTTGAATAAGCAGATATTTTCAGATGAAGTCTTGAATATAAAAAAGGTAGAACTTTTTAATATTTTCT
AACCCTCATTTGCTTTATAA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSILVNKDTKVLVQGLTGKTGTFHTEQALAYHGTQMVGGVNPKKGGETWEGSKGETLPIFASVAEGKEKTGADASVIYVP
PAGAAAAIIEAVEAEIRLIICITEGIPVMDMVKVKARLEKSKSRLIGPNCPGILTPNECKIGIMPGSIFRKGSVGVVSRS
GTLTYEAVFQTSHEGLGQTTAIGIGGDPVKGTEFIDVLEMFLADDETQSIVMIGEIGGSAEEEAAQFLQDEAKKGRKKPV
VGFIAGRTAPPGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPSQIGKTLMSVLKG

Sequences:

>Translated_300_residues
MSILVNKDTKVLVQGLTGKTGTFHTEQALAYHGTQMVGGVNPKKGGETWEGSKGETLPIFASVAEGKEKTGADASVIYVP
PAGAAAAIIEAVEAEIRLIICITEGIPVMDMVKVKARLEKSKSRLIGPNCPGILTPNECKIGIMPGSIFRKGSVGVVSRS
GTLTYEAVFQTSHEGLGQTTAIGIGGDPVKGTEFIDVLEMFLADDETQSIVMIGEIGGSAEEEAAQFLQDEAKKGRKKPV
VGFIAGRTAPPGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPSQIGKTLMSVLKG
>Mature_299_residues
SILVNKDTKVLVQGLTGKTGTFHTEQALAYHGTQMVGGVNPKKGGETWEGSKGETLPIFASVAEGKEKTGADASVIYVPP
AGAAAAIIEAVEAEIRLIICITEGIPVMDMVKVKARLEKSKSRLIGPNCPGILTPNECKIGIMPGSIFRKGSVGVVSRSG
TLTYEAVFQTSHEGLGQTTAIGIGGDPVKGTEFIDVLEMFLADDETQSIVMIGEIGGSAEEEAAQFLQDEAKKGRKKPVV
GFIAGRTAPPGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPSQIGKTLMSVLKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=293, Percent_Identity=62.7986348122867, Blast_Score=307, Evalue=9e-84,
Organism=Homo sapiens, GI38569423, Length=317, Percent_Identity=27.4447949526814, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38569421, Length=317, Percent_Identity=27.4447949526814, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786949, Length=299, Percent_Identity=59.5317725752508, Blast_Score=347, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI17553126, Length=300, Percent_Identity=60.6666666666667, Blast_Score=346, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI17550194, Length=300, Percent_Identity=59, Blast_Score=343, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17557344, Length=309, Percent_Identity=27.831715210356, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17551266, Length=310, Percent_Identity=27.741935483871, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=300, Percent_Identity=50.6666666666667, Blast_Score=280, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21356559, Length=295, Percent_Identity=59.6610169491525, Blast_Score=356, Evalue=8e-99,
Organism=Drosophila melanogaster, GI28574296, Length=299, Percent_Identity=62.876254180602, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI281363477, Length=263, Percent_Identity=30.0380228136882, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363475, Length=263, Percent_Identity=30.0380228136882, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363473, Length=263, Percent_Identity=30.0380228136882, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30992; Mature: 30861

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVNKDTKVLVQGLTGKTGTFHTEQALAYHGTQMVGGVNPKKGGETWEGSKGETLPIF
CEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEE
ASVAEGKEKTGADASVIYVPPAGAAAAIIEAVEAEIRLIICITEGIPVMDMVKVKARLEK
EECCCCCHHCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHH
SKSRLIGPNCPGILTPNECKIGIMPGSIFRKGSVGVVSRSGTLTYEAVFQTSHEGLGQTT
HHHCCCCCCCCCCCCCCCCEEEEECCHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCEE
AIGIGGDPVKGTEFIDVLEMFLADDETQSIVMIGEIGGSAEEEAAQFLQDEAKKGRKKPV
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
VGFIAGRTAPPGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPSQIGKTLMSVLKG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILVNKDTKVLVQGLTGKTGTFHTEQALAYHGTQMVGGVNPKKGGETWEGSKGETLPIF
EEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEE
ASVAEGKEKTGADASVIYVPPAGAAAAIIEAVEAEIRLIICITEGIPVMDMVKVKARLEK
EECCCCCHHCCCCCEEEEECCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHH
SKSRLIGPNCPGILTPNECKIGIMPGSIFRKGSVGVVSRSGTLTYEAVFQTSHEGLGQTT
HHHCCCCCCCCCCCCCCCCEEEEECCHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCEE
AIGIGGDPVKGTEFIDVLEMFLADDETQSIVMIGEIGGSAEEEAAQFLQDEAKKGRKKPV
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
VGFIAGRTAPPGRTMGHAGAVISGGKGGAEDKIAAMESAGIKVSPSPSQIGKTLMSVLKG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]