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The map label for this gene is ilvC

Identifier: 49475823

GI number: 49475823

Start: 1196010

End: 1197029

Strand: Reverse

Name: ilvC

Synonym: BH10890

Alternate gene names: 49475823

Gene position: 1197029-1196010 (Counterclockwise)

Preceding gene: 49475824

Following gene: 49475821

Centisome position: 61.99

GC content: 40.39

Gene sequence:

>1020_bases
ATGCGTGTTTATTATGATCGTGATGCGAATGTTAATTTAATTAAAGAAAAAAAAGTGGCTATTGTTGGTTATGGTTCACA
AGGGCGAGCGCATGCTTTAAATCTGAGAGATTTCGGTGTTAAAAATGTGAAAATTGCTTTGCGTTCGGAGTCGGCAACAG
TTAAAAAAGCTGTCGCAGACGGTTTTGAGGTTGTTTGTGTTGCTGAAGCGGCAAAATGGGCAGATCTCATCATGATGGCA
ACGCCAGATGAATTGCAAGCTGATATTTATAAAGAGCATATTCATGATCATTTACGTGATGGTGCTGTAATTGCTTTTGC
GCATGGTTTGAGTATTCATTTTGGTCTCATTGAGCCTAAAAAAACAGTTGATGTCGTGATGATTGCTCCTAAGGGTCCAG
GTCATACAGTTCGCAATGAATACCAAAATGGTTGTGGTGTTCCTTGTTTAATTGCTGTTGCACAAGATGCTTCAGGGCAT
GCCCATAATGTAGCATTGTCTTATGCATGTGGTCTTGGTGGGGGACGTGCTGGAGTGATTGAAACGACATTTAAAGAAGA
GTGTGAAACTGATCTTTTTGGTGAACAAGCTGTTCTGTGTGGTGGTCTTGTTGAGCTTATTCGAGCAGGTTATGAAACAC
TAACAGAAGCAGGCTATGCGCCGGAAATGGCTTATTTTGAGTGTTTGCATGAGGTTAAATTGATTGTTGATCTCATGTAT
GAAGGTGGCATTGCAAATATGAATTATTCCATTTCCAATACGGCGGAATGGGGCGAATATATGTCTGGTCCACGCGTGAT
TACAGATGAGACAAGAGCAGAAATGAAGCGTATTTTGAAAGATATTCAGACAGGTAAATTTACATCGAATTGGATTCAGG
AATATAAAGCCGGTGCTGCTCATTTTAAAGGGATGCGCCGTTTGAATGATAGCCATCCTATTGAAGAAGTTGGGAAAAAA
CTCCGTTCTATGATGCCTTGGATAAAGGCGAATGCTTTGGTTGATAAAGAACGTAATTGA

Upstream 100 bases:

>100_bases
TGTTTATTCTAGTGTGTGAAGCACTTAGGGGTGGTTTTAGCTTTTTATTCAATAAAAAATCTAAAATTCAGTTTTAATAT
AAAGATAAGGAAGTATTTTC

Downstream 100 bases:

>100_bases
AGTTTATATGAAATATTAGTAAACAGCTTTTACGCTTTATGTACAAAAAGGGTAACTTTGGTTACCCTTTTTTGATATGC
CTTTTATGTATAATTTTATT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDANVNLIKEKKVAIVGYGSQGRAHALNLRDFGVKNVKIALRSESATVKKAVADGFEVVCVAEAAKWADLIMMA
TPDELQADIYKEHIHDHLRDGAVIAFAHGLSIHFGLIEPKKTVDVVMIAPKGPGHTVRNEYQNGCGVPCLIAVAQDASGH
AHNVALSYACGLGGGRAGVIETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLMY
EGGIANMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAAHFKGMRRLNDSHPIEEVGKK
LRSMMPWIKANALVDKERN

Sequences:

>Translated_339_residues
MRVYYDRDANVNLIKEKKVAIVGYGSQGRAHALNLRDFGVKNVKIALRSESATVKKAVADGFEVVCVAEAAKWADLIMMA
TPDELQADIYKEHIHDHLRDGAVIAFAHGLSIHFGLIEPKKTVDVVMIAPKGPGHTVRNEYQNGCGVPCLIAVAQDASGH
AHNVALSYACGLGGGRAGVIETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLMY
EGGIANMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAAHFKGMRRLNDSHPIEEVGKK
LRSMMPWIKANALVDKERN
>Mature_339_residues
MRVYYDRDANVNLIKEKKVAIVGYGSQGRAHALNLRDFGVKNVKIALRSESATVKKAVADGFEVVCVAEAAKWADLIMMA
TPDELQADIYKEHIHDHLRDGAVIAFAHGLSIHFGLIEPKKTVDVVMIAPKGPGHTVRNEYQNGCGVPCLIAVAQDASGH
AHNVALSYACGLGGGRAGVIETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLMY
EGGIANMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAAHFKGMRRLNDSHPIEEVGKK
LRSMMPWIKANALVDKERN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=296, Percent_Identity=35.8108108108108, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=336, Percent_Identity=30.6547619047619, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BARHE (Q6G2T6)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033864.1
- ProteinModelPortal:   Q6G2T6
- SMR:   Q6G2T6
- GeneID:   2865556
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH10890
- NMPDR:   fig|283166.1.peg.992
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q6G2T6
- ProtClustDB:   PRK05479
- BioCyc:   BHEN283166:BH10890-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37350; Mature: 37350

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDANVNLIKEKKVAIVGYGSQGRAHALNLRDFGVKNVKIALRSESATVKKAVAD
CEEEECCCCCEEEEEECEEEEEEECCCCCEEEECHHHCCCCEEEEEEECCCHHHHHHHHC
GFEVVCVAEAAKWADLIMMATPDELQADIYKEHIHDHLRDGAVIAFAHGLSIHFGLIEPK
CCEEEEEECHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEEECCCC
KTVDVVMIAPKGPGHTVRNEYQNGCGVPCLIAVAQDASGHAHNVALSYACGLGGGRAGVI
CCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLMY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAA
CCCCCCCCCCCCCCHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HFKGMRRLNDSHPIEEVGKKLRSMMPWIKANALVDKERN
HHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHECCCCCC
>Mature Secondary Structure
MRVYYDRDANVNLIKEKKVAIVGYGSQGRAHALNLRDFGVKNVKIALRSESATVKKAVAD
CEEEECCCCCEEEEEECEEEEEEECCCCCEEEECHHHCCCCEEEEEEECCCHHHHHHHHC
GFEVVCVAEAAKWADLIMMATPDELQADIYKEHIHDHLRDGAVIAFAHGLSIHFGLIEPK
CCEEEEEECHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEEECCCC
KTVDVVMIAPKGPGHTVRNEYQNGCGVPCLIAVAQDASGHAHNVALSYACGLGGGRAGVI
CCEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIRAGYETLTEAGYAPEMAYFECLHEVKLIVDLMY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYMSGPRVITDETRAEMKRILKDIQTGKFTSNWIQEYKAGAA
CCCCCCCCCCCCCCHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HFKGMRRLNDSHPIEEVGKKLRSMMPWIKANALVDKERN
HHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA