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The map label for this gene is nuoF [H]

Identifier: 49475653

GI number: 49475653

Start: 1006185

End: 1007492

Strand: Reverse

Name: nuoF [H]

Synonym: BH08900

Alternate gene names: 49475653

Gene position: 1007492-1006185 (Counterclockwise)

Preceding gene: 49475654

Following gene: 49475652

Centisome position: 52.17

GC content: 42.13

Gene sequence:

>1308_bases
ATGCTGGCTGATAAGGATCGCATTTTCACCAATCTTTATGGTTTAAAAGACAAATCATTAAAGGCTGCGATATCACGTGG
ACATTGGGATGGTACCAGGGCAATTATCGATAAAGGTCGTGATTGGATTATTGATGAGATGAAGGCATCGGGTTTGCGTG
GCCGTGGTGGTGCGGGTTTTCCTACTGGAATGAAGTGGTCTTTTATGCCAAAACAGAGCGATGGTCGGCCTCATTATTTG
GTTGTAAATGCAGATGAATCAGAGCCTGGTACATGTAAAGATCGCGATATTTTGCGACATGATCCCCATACTTTAATTGA
AGGATGTGTACTTGCTACTTTTGCGATGGGAGCAAATGTCGCTTTTATTTATATTCGTGGTGAATATATTCGTGAACGTG
AAGCGCTTCAAGCTGCCGTTGATGAATGTTATGATGCTGGTTTGCTTGGCAAAAAAACGAAATATGGGCATGCTTGTGAT
ATTATTATTCATCATGGTGCTGGTGCTTATATCTGTGGGGAAGAAACCGCTCTTCTTGAAAGTCTTGAAGGAAAAAAAGG
ACAACCTCGGCTTAAACCGCCATTTCCTGCAAATATGGGAATTTATGGCTGTCCAACCACAGTCAATAATGTAGAGTCCA
TTGCTGTTGTGCCAACAATTTTGCGTCGCGGTGCTTCATGGTTTTCATCAATTGGGCGTGCAAATAATGTTGGAACGAAA
TTGTTTATGGTTTCTGGGCATGTGAATGCACCTTGTACATTTGAAGAAGCTCTTGGAGTTTCTTTTCGTGAATTAATTGA
AAAACATACCGGCGGTATTCGTGGTGGGTGGAATAATCTTTTAGCAGTTATTCCAGGAGGGGCTTCTTGCCCGGTCGTTC
GTGGTGAGGATATGGTGGATGCGATTATGGATTTTGATGGAATGCGCGATGTCGGATCTTCTTTTGGTACAGGAGGTATG
ATTGTTATGGATAAATCGACCGATATTATCAAGGCAATTTGGCGTATAGCAGCTTTTTTTAAGCATGAAAGTTGTGGTCA
GTGCACACCATGTCGTGAAGGAACGGGTTGGATGATGCGTCTTTTAGGACGTATGGTTGAGGGAAAGGCGCAAAAACGCG
AGATTGATCTTTTATTTGAGGTTTCTAAACAAGTTGAAGGGCACACTATTTGTGCACTTGGTGATGCTGCCGCGTGGCCT
ATACAGGGGTTAATACGTAATTTTCGTCCAGAAATTGAGCGTAGAATTGATGATTATACGCGTAATGTAGTCCAAAGAAA
AAATATTGCTTTAGAAGCAGTAGAATAG

Upstream 100 bases:

>100_bases
TTAAGGTTTAACTAAAAGTCAGAATTTTTGAAAAGATGTTTTAAAATTGTATTTGAGGGAAAGCTAAGAATGCTAGGCAC
AATAGAGAAAAAGGTAAGGT

Downstream 100 bases:

>100_bases
AGGGTTTTGCTTTAAGAGCAACAGAATGCAAATTTTAAGTGGGTTATCCGCAGGCTGGATGAGTGATGATAAATATCAAA
GTTGATGGTAAAGAGATCGA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLADKDRIFTNLYGLKDKSLKAAISRGHWDGTRAIIDKGRDWIIDEMKASGLRGRGGAGFPTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDRDILRHDPHTLIEGCVLATFAMGANVAFIYIRGEYIREREALQAAVDECYDAGLLGKKTKYGHACD
IIIHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGIYGCPTTVNNVESIAVVPTILRRGASWFSSIGRANNVGTK
LFMVSGHVNAPCTFEEALGVSFRELIEKHTGGIRGGWNNLLAVIPGGASCPVVRGEDMVDAIMDFDGMRDVGSSFGTGGM
IVMDKSTDIIKAIWRIAAFFKHESCGQCTPCREGTGWMMRLLGRMVEGKAQKREIDLLFEVSKQVEGHTICALGDAAAWP
IQGLIRNFRPEIERRIDDYTRNVVQRKNIALEAVE

Sequences:

>Translated_435_residues
MLADKDRIFTNLYGLKDKSLKAAISRGHWDGTRAIIDKGRDWIIDEMKASGLRGRGGAGFPTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDRDILRHDPHTLIEGCVLATFAMGANVAFIYIRGEYIREREALQAAVDECYDAGLLGKKTKYGHACD
IIIHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGIYGCPTTVNNVESIAVVPTILRRGASWFSSIGRANNVGTK
LFMVSGHVNAPCTFEEALGVSFRELIEKHTGGIRGGWNNLLAVIPGGASCPVVRGEDMVDAIMDFDGMRDVGSSFGTGGM
IVMDKSTDIIKAIWRIAAFFKHESCGQCTPCREGTGWMMRLLGRMVEGKAQKREIDLLFEVSKQVEGHTICALGDAAAWP
IQGLIRNFRPEIERRIDDYTRNVVQRKNIALEAVE
>Mature_435_residues
MLADKDRIFTNLYGLKDKSLKAAISRGHWDGTRAIIDKGRDWIIDEMKASGLRGRGGAGFPTGMKWSFMPKQSDGRPHYL
VVNADESEPGTCKDRDILRHDPHTLIEGCVLATFAMGANVAFIYIRGEYIREREALQAAVDECYDAGLLGKKTKYGHACD
IIIHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANMGIYGCPTTVNNVESIAVVPTILRRGASWFSSIGRANNVGTK
LFMVSGHVNAPCTFEEALGVSFRELIEKHTGGIRGGWNNLLAVIPGGASCPVVRGEDMVDAIMDFDGMRDVGSSFGTGGM
IVMDKSTDIIKAIWRIAAFFKHESCGQCTPCREGTGWMMRLLGRMVEGKAQKREIDLLFEVSKQVEGHTICALGDAAAWP
IQGLIRNFRPEIERRIDDYTRNVVQRKNIALEAVE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=63.0071599045346, Blast_Score=567, Evalue=1e-162,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=63.0071599045346, Blast_Score=566, Evalue=1e-161,
Organism=Escherichia coli, GI1788620, Length=402, Percent_Identity=41.044776119403, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17531727, Length=427, Percent_Identity=61.5925058548009, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI19920794, Length=423, Percent_Identity=64.3026004728132, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI45550452, Length=433, Percent_Identity=63.2794457274827, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24653819, Length=423, Percent_Identity=44.6808510638298, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24653817, Length=423, Percent_Identity=41.6075650118203, Blast_Score=339, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47796; Mature: 47796

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADKDRIFTNLYGLKDKSLKAAISRGHWDGTRAIIDKGRDWIIDEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
PTGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDRDILRHDPHTLIEGCVLATFAMGANV
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCE
AFIYIRGEYIREREALQAAVDECYDAGLLGKKTKYGHACDIIIHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGIYGCPTTVNNVESIAVVPTILRRGASWFSSIGRANNVGTK
HHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCE
LFMVSGHVNAPCTFEEALGVSFRELIEKHTGGIRGGWNNLLAVIPGGASCPVVRGEDMVD
EEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEECCCHHHH
AIMDFDGMRDVGSSFGTGGMIVMDKSTDIIKAIWRIAAFFKHESCGQCTPCREGTGWMMR
HHHCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
LLGRMVEGKAQKREIDLLFEVSKQVEGHTICALGDAAAWPIQGLIRNFRPEIERRIDDYT
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNVVQRKNIALEAVE
HHHHHHCCCEEEECC
>Mature Secondary Structure
MLADKDRIFTNLYGLKDKSLKAAISRGHWDGTRAIIDKGRDWIIDEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCC
PTGMKWSFMPKQSDGRPHYLVVNADESEPGTCKDRDILRHDPHTLIEGCVLATFAMGANV
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCE
AFIYIRGEYIREREALQAAVDECYDAGLLGKKTKYGHACDIIIHHGAGAYICGEETALLE
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANMGIYGCPTTVNNVESIAVVPTILRRGASWFSSIGRANNVGTK
HHCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCE
LFMVSGHVNAPCTFEEALGVSFRELIEKHTGGIRGGWNNLLAVIPGGASCPVVRGEDMVD
EEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEECCCHHHH
AIMDFDGMRDVGSSFGTGGMIVMDKSTDIIKAIWRIAAFFKHESCGQCTPCREGTGWMMR
HHHCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
LLGRMVEGKAQKREIDLLFEVSKQVEGHTICALGDAAAWPIQGLIRNFRPEIERRIDDYT
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHH
RNVVQRKNIALEAVE
HHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]