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The map label for this gene is nuoN [H]

Identifier: 49475645

GI number: 49475645

Start: 996529

End: 997983

Strand: Reverse

Name: nuoN [H]

Synonym: BH08820

Alternate gene names: 49475645

Gene position: 997983-996529 (Counterclockwise)

Preceding gene: 49475646

Following gene: 49475644

Centisome position: 51.68

GC content: 36.84

Gene sequence:

>1455_bases
ATGCAAACTGAAATAATCACTCAATTAGTGTTAATTTTTCCAGAGATTTTAATAGCTTTGGGGGGAATCACGTTACTTTT
GTTTGGTGTTTATTCCAAAGCAAGTTCCTCCTTAACCGTGACTGGTTTGGCCATTGCTCTTTTTGTAGCAACCATTGTTA
TCATCATAATTTTTCCAAAAAGTGGCTTATTTCAGACCAATGCGCTTATTATTGACTCTTTCGGCCGTTATATGAAAATT
TTAACGCTTATTGGTGCACTCTTTGCTCTTATTATGTCTGTGAATTTTACTAGTACGCAGAAGTTTGATATATTTGAATT
TCCGGTACTCGTTCTTTTAGCAACCCTTGGTATGATGCTGATGATTTCAGCAGGTAATATGTTGTCACTTTATATGGGGT
TAGAACTACAATCTTTGGCTTTATATGTTCTCGCTGCGATTAATCGTAATAATATAAAATCTTCTGAAGCGGGTATAAAG
TATTTTGCTTTAGGGGCTTTATCTTCGGGCCTTCTGCTTTATGGAATTTCTCTGGTTTATGGTTTTACCGGTCAAATTGG
TTTTCGTGAAATTGCTGTTGCGTTAAAGGGTGAAAACTTACCATTAGGCGTTATCTTTGGAATTGTCTTTATTTTAGCTG
GTTTGGCTTTTAAAATTTCTGCTGTTCCATTTCATATGTGGACACCTGATGTTTATGAAGGAGCACCAACACCAATTACA
GCATTTTTTGCTGGTGCTCCTAAAGTTGCGGCAATGGCCTTAATAGTTCGTATTATTGTTATGACCTTTATTCCACTGGA
GAATACTGATGGCTCTATGCCGGCATGGCAGCAAATTTTGGTGTTTATGGCGATTGCTTCAATGATACTTGGTGCATTTG
CTGCAATTGGCCAGAGCAACATTAAACGTTTAATGGCTTATTCGTCGATCAGTCATATGGGATATGCACTTGTTGGGTTA
GCTTCTGGAGATATGCTGGGGATAAAAAGCGTTATTCTTTATATGACTATTTATCTTAGTATGACGATTGGTTCCTTTGC
TTTTATTCTTGGAATGCGCTCTAGTGATGGAAATGTTGAAGATATTTATGATCTTTCAGGATTGGTAAAGACAAATCCAT
TTATGGCTATTACGATGACAATACAACTTTTCTCTTTAGCAAGTATACCACCTATGGCCGGTTTTTTTGGAAAGTGGTAT
ACATTTTCTGCTGCTGTTCATGCTGGTCTTACTCCACTTGCTATCGTTGGTATGATAGCGTCTGTTGTTGGGGCTTTTTA
CTATTTACGTCTCATTAAAATTATGTGGTTTGATGATGCAAAAGCGCATTTTATTGTTTTATCGAATGAGTTTCGGTTTT
GTCTCAGTTTTTCTGCATTCTTTATTTTATCTTATACGCTTTTTGGGATTTGGTTTGCTGACTTGGCAGAACGAGCAGCT
ACTGCATTGTTTTAA

Upstream 100 bases:

>100_bases
CAATATTTTTTGGTATTTATCCAACGCCTATTCTTAAAGCAACGGCGTTTTCCGTGAAAGCTCTCATCAATAAACTACAC
TAGATAAGAGAAGAATGCTC

Downstream 100 bases:

>100_bases
TGAAAATGGATTATATCTTATCAGATTTTGCACAAAAACAAGGATACGCTGTTGAATCGTATGAAATTGTTGATTCAACA
AATTACATTGCACAGCAAAA

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MQTEIITQLVLIFPEILIALGGITLLLFGVYSKASSSLTVTGLAIALFVATIVIIIIFPKSGLFQTNALIIDSFGRYMKI
LTLIGALFALIMSVNFTSTQKFDIFEFPVLVLLATLGMMLMISAGNMLSLYMGLELQSLALYVLAAINRNNIKSSEAGIK
YFALGALSSGLLLYGISLVYGFTGQIGFREIAVALKGENLPLGVIFGIVFILAGLAFKISAVPFHMWTPDVYEGAPTPIT
AFFAGAPKVAAMALIVRIIVMTFIPLENTDGSMPAWQQILVFMAIASMILGAFAAIGQSNIKRLMAYSSISHMGYALVGL
ASGDMLGIKSVILYMTIYLSMTIGSFAFILGMRSSDGNVEDIYDLSGLVKTNPFMAITMTIQLFSLASIPPMAGFFGKWY
TFSAAVHAGLTPLAIVGMIASVVGAFYYLRLIKIMWFDDAKAHFIVLSNEFRFCLSFSAFFILSYTLFGIWFADLAERAA
TALF

Sequences:

>Translated_484_residues
MQTEIITQLVLIFPEILIALGGITLLLFGVYSKASSSLTVTGLAIALFVATIVIIIIFPKSGLFQTNALIIDSFGRYMKI
LTLIGALFALIMSVNFTSTQKFDIFEFPVLVLLATLGMMLMISAGNMLSLYMGLELQSLALYVLAAINRNNIKSSEAGIK
YFALGALSSGLLLYGISLVYGFTGQIGFREIAVALKGENLPLGVIFGIVFILAGLAFKISAVPFHMWTPDVYEGAPTPIT
AFFAGAPKVAAMALIVRIIVMTFIPLENTDGSMPAWQQILVFMAIASMILGAFAAIGQSNIKRLMAYSSISHMGYALVGL
ASGDMLGIKSVILYMTIYLSMTIGSFAFILGMRSSDGNVEDIYDLSGLVKTNPFMAITMTIQLFSLASIPPMAGFFGKWY
TFSAAVHAGLTPLAIVGMIASVVGAFYYLRLIKIMWFDDAKAHFIVLSNEFRFCLSFSAFFILSYTLFGIWFADLAERAA
TALF
>Mature_484_residues
MQTEIITQLVLIFPEILIALGGITLLLFGVYSKASSSLTVTGLAIALFVATIVIIIIFPKSGLFQTNALIIDSFGRYMKI
LTLIGALFALIMSVNFTSTQKFDIFEFPVLVLLATLGMMLMISAGNMLSLYMGLELQSLALYVLAAINRNNIKSSEAGIK
YFALGALSSGLLLYGISLVYGFTGQIGFREIAVALKGENLPLGVIFGIVFILAGLAFKISAVPFHMWTPDVYEGAPTPIT
AFFAGAPKVAAMALIVRIIVMTFIPLENTDGSMPAWQQILVFMAIASMILGAFAAIGQSNIKRLMAYSSISHMGYALVGL
ASGDMLGIKSVILYMTIYLSMTIGSFAFILGMRSSDGNVEDIYDLSGLVKTNPFMAITMTIQLFSLASIPPMAGFFGKWY
TFSAAVHAGLTPLAIVGMIASVVGAFYYLRLIKIMWFDDAKAHFIVLSNEFRFCLSFSAFFILSYTLFGIWFADLAERAA
TALF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=302, Percent_Identity=23.841059602649, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI145693160, Length=435, Percent_Identity=33.5632183908046, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788831, Length=300, Percent_Identity=27.6666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788614, Length=341, Percent_Identity=25.2199413489736, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788827, Length=293, Percent_Identity=27.9863481228669, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=272, Percent_Identity=26.1029411764706, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788829, Length=240, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788613, Length=120, Percent_Identity=30, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52425; Mature: 52425

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTEIITQLVLIFPEILIALGGITLLLFGVYSKASSSLTVTGLAIALFVATIVIIIIFPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEEECC
SGLFQTNALIIDSFGRYMKILTLIGALFALIMSVNFTSTQKFDIFEFPVLVLLATLGMML
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MISAGNMLSLYMGLELQSLALYVLAAINRNNIKSSEAGIKYFALGALSSGLLLYGISLVY
HHCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHH
GFTGQIGFREIAVALKGENLPLGVIFGIVFILAGLAFKISAVPFHMWTPDVYEGAPTPIT
HCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCCHH
AFFAGAPKVAAMALIVRIIVMTFIPLENTDGSMPAWQQILVFMAIASMILGAFAAIGQSN
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHH
IKRLMAYSSISHMGYALVGLASGDMLGIKSVILYMTIYLSMTIGSFAFILGMRSSDGNVE
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
DIYDLSGLVKTNPFMAITMTIQLFSLASIPPMAGFFGKWYTFSAAVHAGLTPLAIVGMIA
HHHHHHCHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVGAFYYLRLIKIMWFDDAKAHFIVLSNEFRFCLSFSAFFILSYTLFGIWFADLAERAA
HHHHHHHHHHHHHHHEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TALF
HHCC
>Mature Secondary Structure
MQTEIITQLVLIFPEILIALGGITLLLFGVYSKASSSLTVTGLAIALFVATIVIIIIFPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHEEEECC
SGLFQTNALIIDSFGRYMKILTLIGALFALIMSVNFTSTQKFDIFEFPVLVLLATLGMML
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MISAGNMLSLYMGLELQSLALYVLAAINRNNIKSSEAGIKYFALGALSSGLLLYGISLVY
HHCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHCCHHHHHHHHHH
GFTGQIGFREIAVALKGENLPLGVIFGIVFILAGLAFKISAVPFHMWTPDVYEGAPTPIT
HCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCCHH
AFFAGAPKVAAMALIVRIIVMTFIPLENTDGSMPAWQQILVFMAIASMILGAFAAIGQSN
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHH
IKRLMAYSSISHMGYALVGLASGDMLGIKSVILYMTIYLSMTIGSFAFILGMRSSDGNVE
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
DIYDLSGLVKTNPFMAITMTIQLFSLASIPPMAGFFGKWYTFSAAVHAGLTPLAIVGMIA
HHHHHHCHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVGAFYYLRLIKIMWFDDAKAHFIVLSNEFRFCLSFSAFFILSYTLFGIWFADLAERAA
HHHHHHHHHHHHHHHEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TALF
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA