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The map label for this gene is lolC [H]

Identifier: 49475641

GI number: 49475641

Start: 991249

End: 992517

Strand: Reverse

Name: lolC [H]

Synonym: BH08780

Alternate gene names: 49475641

Gene position: 992517-991249 (Counterclockwise)

Preceding gene: 49475642

Following gene: 49475640

Centisome position: 51.4

GC content: 35.54

Gene sequence:

>1269_bases
ATGAAGTGGTTGAGGAGTAAATGGTTTTCATCTTATGAATGGATGATCGCTTTTCGTTATATGATTCCTAATAAAAAACA
CGTAGTTGCCTCTGTAATTTCAATTATCTCTCTCGTTGGAATTATGTTAGGGGTTTTTGCTCTTGTTGTTGTTATGGCAG
TAATGAATGGTTTTCGTACAGAGCTTCTCAATCGTATTCTTGGTATGAATGGGCATCTTATTATTCAAACAATTAATTCT
GGTTTTTCCGATTATAATAATCTTATTCCTTCTATAGAATCCGTGAATGGTGTTAAATTTGCTTTGCCTGTTATTGAGGG
GCAGGCGCTTGTGCAGGGTGAACTTCAAGGAGGATCTGGTGCTTTAGTTCGTGGTATGCGCAAACAAGATTTAGAGAAAC
TTAAAACAGTATCGGAAAATATTAAATTAGGATCGCTTGCTCAATTTGATCAAGAGGAAGGTGTTGCAATTGGAATTAGT
TTGGCAGAAAAGTTAGGTCTTACAATAGGGAGTGATCTTCGTATTATTACTCCAGATGGTGATGAGACTCCTTTTGGAGT
TACGCCACGTGTTAAAGCCTATAAAGTGGTTGCTATTTTTGAAGTTGGTATGTCTGAATATGATTCAATATTCGTTTTTA
TGCCTCTTCATGAAGCACAAGCATTTTTTAATTTGGGAAATAAAATCCAATCTTTAGAGTTATTTTTGAATGATCCTGAT
TCTGTTGATCGAATAAAACCAATCTTAGAGAAACTTATTGATCAACAGGTCTATTTAATTGATTGGCGTACGCGCAATCA
AGCTTTTTTTTCAGCCTTACAGATTGAACGAAATGTTATGTTTTTCATTCTTTCTCTTATTGTTCTTGTTGCTGCTTTAA
ATATTATTTCAGGCCTGATTATGCTTGTAAAAGATAAAAGTCATGATATTGCAATTTTACGTACAATGGGGGCACAACAA
AGTGCAATTCTGCGCATATTTATCGTCACTGGTATGATGATTGGATTAATTGGAACACTCTTGGGCTTAATTTTTGGTGT
CATAGCGACCGCGAATATCAATCATATTCAAGACTTTATATCTTGGTTATTTAATGTTGATGTTTTTAATCCTCAACTTT
ATTTTTTAACAAAATTGCCTGCCAAAATTGAGTGGGGACAGACAGTCATGGTTGCTGTAATGGCTTTATTTTTGTCATTC
CTTGCTGCTCTCATTCCGGCCTGGCGCGCTGCTAAGCTAGATCCTGTACAAGCTTTGAGGTATGAATAA

Upstream 100 bases:

>100_bases
AAAATGAAGTTGAGATTAAAGATAGAAAAACGGGTATAAAAAAATCTCTAACGGTTGAAAATGTACTCAACCAGTTTTCT
GTAATTTGATAGGCAGTGTT

Downstream 100 bases:

>100_bases
TGACAGCTATTTTAGAGCTTGTAGAGATTGAACGCCATTTTTTAGGGGGAAATAAACCTCTTATTATTTTGGATAAAGCA
AATTTTATCCTTAATCGTGG

Product: lipoprotein releasing system transmembrane protein lolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKWLRSKWFSSYEWMIAFRYMIPNKKHVVASVISIISLVGIMLGVFALVVVMAVMNGFRTELLNRILGMNGHLIIQTINS
GFSDYNNLIPSIESVNGVKFALPVIEGQALVQGELQGGSGALVRGMRKQDLEKLKTVSENIKLGSLAQFDQEEGVAIGIS
LAEKLGLTIGSDLRIITPDGDETPFGVTPRVKAYKVVAIFEVGMSEYDSIFVFMPLHEAQAFFNLGNKIQSLELFLNDPD
SVDRIKPILEKLIDQQVYLIDWRTRNQAFFSALQIERNVMFFILSLIVLVAALNIISGLIMLVKDKSHDIAILRTMGAQQ
SAILRIFIVTGMMIGLIGTLLGLIFGVIATANINHIQDFISWLFNVDVFNPQLYFLTKLPAKIEWGQTVMVAVMALFLSF
LAALIPAWRAAKLDPVQALRYE

Sequences:

>Translated_422_residues
MKWLRSKWFSSYEWMIAFRYMIPNKKHVVASVISIISLVGIMLGVFALVVVMAVMNGFRTELLNRILGMNGHLIIQTINS
GFSDYNNLIPSIESVNGVKFALPVIEGQALVQGELQGGSGALVRGMRKQDLEKLKTVSENIKLGSLAQFDQEEGVAIGIS
LAEKLGLTIGSDLRIITPDGDETPFGVTPRVKAYKVVAIFEVGMSEYDSIFVFMPLHEAQAFFNLGNKIQSLELFLNDPD
SVDRIKPILEKLIDQQVYLIDWRTRNQAFFSALQIERNVMFFILSLIVLVAALNIISGLIMLVKDKSHDIAILRTMGAQQ
SAILRIFIVTGMMIGLIGTLLGLIFGVIATANINHIQDFISWLFNVDVFNPQLYFLTKLPAKIEWGQTVMVAVMALFLSF
LAALIPAWRAAKLDPVQALRYE
>Mature_422_residues
MKWLRSKWFSSYEWMIAFRYMIPNKKHVVASVISIISLVGIMLGVFALVVVMAVMNGFRTELLNRILGMNGHLIIQTINS
GFSDYNNLIPSIESVNGVKFALPVIEGQALVQGELQGGSGALVRGMRKQDLEKLKTVSENIKLGSLAQFDQEEGVAIGIS
LAEKLGLTIGSDLRIITPDGDETPFGVTPRVKAYKVVAIFEVGMSEYDSIFVFMPLHEAQAFFNLGNKIQSLELFLNDPD
SVDRIKPILEKLIDQQVYLIDWRTRNQAFFSALQIERNVMFFILSLIVLVAALNIISGLIMLVKDKSHDIAILRTMGAQQ
SAILRIFIVTGMMIGLIGTLLGLIFGVIATANINHIQDFISWLFNVDVFNPQLYFLTKLPAKIEWGQTVMVAVMALFLSF
LAALIPAWRAAKLDPVQALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=411, Percent_Identity=29.9270072992701, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=31.7191283292978, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 47031; Mature: 47031

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWLRSKWFSSYEWMIAFRYMIPNKKHVVASVISIISLVGIMLGVFALVVVMAVMNGFRT
CCCHHHHHCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLNRILGMNGHLIIQTINSGFSDYNNLIPSIESVNGVKFALPVIEGQALVQGELQGGSG
HHHHHHHCCCCCEEEEEHHCCHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEECCCCCH
ALVRGMRKQDLEKLKTVSENIKLGSLAQFDQEEGVAIGISLAEKLGLTIGSDLRIITPDG
HHHHCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEHHHHHCCEECCCEEEECCCC
DETPFGVTPRVKAYKVVAIFEVGMSEYDSIFVFMPLHEAQAFFNLGNKIQSLELFLNDPD
CCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHCCHHEEEEEEECCCC
SVDRIKPILEKLIDQQVYLIDWRTRNQAFFSALQIERNVMFFILSLIVLVAALNIISGLI
CHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVKDKSHDIAILRTMGAQQSAILRIFIVTGMMIGLIGTLLGLIFGVIATANINHIQDFI
HEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SWLFNVDVFNPQLYFLTKLPAKIEWGQTVMVAVMALFLSFLAALIPAWRAAKLDPVQALR
HHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YE
CC
>Mature Secondary Structure
MKWLRSKWFSSYEWMIAFRYMIPNKKHVVASVISIISLVGIMLGVFALVVVMAVMNGFRT
CCCHHHHHCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLNRILGMNGHLIIQTINSGFSDYNNLIPSIESVNGVKFALPVIEGQALVQGELQGGSG
HHHHHHHCCCCCEEEEEHHCCHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEECCCCCH
ALVRGMRKQDLEKLKTVSENIKLGSLAQFDQEEGVAIGISLAEKLGLTIGSDLRIITPDG
HHHHCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEHHHHHCCEECCCEEEECCCC
DETPFGVTPRVKAYKVVAIFEVGMSEYDSIFVFMPLHEAQAFFNLGNKIQSLELFLNDPD
CCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHCCHHEEEEEEECCCC
SVDRIKPILEKLIDQQVYLIDWRTRNQAFFSALQIERNVMFFILSLIVLVAALNIISGLI
CHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVKDKSHDIAILRTMGAQQSAILRIFIVTGMMIGLIGTLLGLIFGVIATANINHIQDFI
HEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SWLFNVDVFNPQLYFLTKLPAKIEWGQTVMVAVMALFLSFLAALIPAWRAAKLDPVQALR
HHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]