| Definition | Bartonella henselae str. Houston-1, complete genome. |
|---|---|
| Accession | NC_005956 |
| Length | 1,931,047 |
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The map label for this gene is topA [H]
Identifier: 49475581
GI number: 49475581
Start: 919836
End: 922397
Strand: Reverse
Name: topA [H]
Synonym: BH08160
Alternate gene names: 49475581
Gene position: 922397-919836 (Counterclockwise)
Preceding gene: 49475582
Following gene: 49475580
Centisome position: 47.77
GC content: 39.07
Gene sequence:
>2562_bases ATGAATATCGTTATCGTTGAATCTCCAGCAAAAGCAAAAACAATTAATAAATATCTTGGATCTCAATATAAAGTAGTAGC ATCATTTGGACATGTTCGTGATTTGCCCGCAAAAGACGGCTCCGTTCTACCTGATCAAGATTTTTCTATGAAATGGGATG TAGATTCTGCTGCCGCTAAACGTTTAAATGAAATAGCAAAAGCAGTTAAAGAAGCCGATAGTCTTATCTTAGCGACAGAC CCTGATCGTGAAGGGGAAGCTATTTCATGGCATATTCTAGATGTTCTTCGTCAAAAAAAAGTTTTAAAAGATAAACCTGT TAAGCGGGTTGTATTCAATGCCATTACCAAAAAGTCTGTACTTGATGCAATGAATAATCCACGTGATATTGATACATCAC TTGTAAATGCTTATCTTGCACGTCGTGCTCTCGATTATCTTGTTGGTTTTACACTCTCACCTGTTTTATGGCGTAAACTC CCCGGAGCACGTTCGGCTGGTCGGGTTCAATCTGTTGCTCTGCGTATTATTTGTGATCGTGAATCAGAAATAGAACATTT TATCAAAGAGGATTATTGGTCTATTACAACAGACTTAAAAACCATCCGCAATGACGGCTTTCAAGCAAGATTAACAATGT TTAATCAAAAAAAGATTGGCAAGCTTGACATTCAATCTCAAGAACAAGCAGATCAAATTCGCCTTATGTTAGAGAAGGCA AAATATCATGCACTCAGTGTTGAAGCAAAGCCTACAAAGAGAAATCCTTTTCCTCCGTTTACAACATCTACTTTACAACA AGCGGCTTCTTCAAAACTGGGCTTTTCAGCTTCTCGTACCATGCAAATTGCTCAAAAGCTCTATGAAGGGATTGAAATTA ATGGTGAAATGGCTGGGCTTATTACCTATATGCGTACTGATGGTGTACAAATAGCACCAGAAGCCATAGATTCAGCACGA AAAGTAATTCATGAATCTTTTGGTAGTGATTATATTCCTGAAAAACCACGTTTTTATTCAACAAAAGCAAAAAATGCACA GGAAGCACATGAAGCCATCCGTCCAACCGATTTTCAACGTATTCCTAATCAAGTACGGAATTTCCTCGATAGCGATCAGG CAAAACTCTATGAACTGATATGGAAACGCGCTGTTGCTAGCCAAATGCGTTCTGCTGAAATTGAACGCACAACTGTTGAA ATTGAAGCACAGCAAGGGGAAAATTACGCAAATTTACGCGCAACAGGTTCTGTTATTCGTTTTGATGGCTTTCTTTCTCT CTACACTGATCAACGAGATGAAGAAAACAATGAAGAAAACGAAACAACACGTTTGCCACAAATTAATACTGGTGAAGAAC TTACTAAAGAAAAGGTTGACGCCATACAACATACCACTGAACCCCCTCCTCGTTATTCTGAAGCTTCCCTAATTAAAAAG CTTGAAGAGCTAGGAATAGGTCGTCCTTCAACCTATGCATCCACATTGGCTACACTATCTGATCGTGGATATATCATAAT TGATAAACGAAAGCTTATTCCCGATGTTAAAGGACGTATTGTTACAGCCTTTCTTGAAAATTTCTTTAATCGCTATGTAG AATACGGTTTCACGGCAGATCTTGAGGAAAAACTGGATCTTATATCGGATGGAAAGCTTTCTTGGAAAGATGTATTGCGC GATTTTTGGGATGGATTTAATGCTTCTATTACCAATATCCAAGAATTACGTATAACAAATGTTCTTGATGTTTTAAATGT AACATTAGCACCCCTTGCTTTTCCTGTGCGTGAAGATGGAAGTGATGTTCGTTCCTGTCCCTTATGTACAAACGGCCAGT TATCATTAAAACTCGGTCGTTATGGTGCATTTGTTGGCTGTTCTAATTATCCCGAATGCAAATATACACGCCAACTTGGC ACAGATCCAGGAGAAGAGAATGAAGCCATACGGAATGATGAACCCGTTATACTTGGAGTTGACCCTAAAACAGGAAAAGA TGTCACTCTTCGCAATGGTCGTTTTGGGCCCTATATTCAACTTGGTGAAAGCAAAGAAGCTAAGCGTGCAGGGTTACCAA AAGAATGGCAAGCAGAAAAAATCACTCTTGAAAAAGCTTTGTCTTTAATATCCTTGCCCCGTGAAATTGGTATTCATCCT GAAACCGGCAAAACAATCACTGCAACAATTGGCCGGTATGGCCCATACCTTACGCATGATGGAAAATATGCTCCCCTTCT CAATGTAGATGAAGTTTTTGATATTGGCATCAATCGCGCTGTTACAGTACTTGCCGAAAAACAAGAAAATAAAACAAAGC GAAGTAGAACAACAACTGCAGCGTTGGCAACATTAGGGAACCACCCAGATGGGGGAGTTGTCACCGTGCGCAACGGGCGT TATGGTCCCTATGTTAATTGGGGTAAAGTTAATGCAACATTGCCAAAAGATAAAGATCCAATTAATGTGACACTTTCAGA AGCATTAGAACTTATATCGGTTAAAGCATCCGGTAAAAAAACAACCTTAAAAAGAGCTTCTACTAAAACAAAAGAGACAT AA
Upstream 100 bases:
>100_bases ATATTAATGTTTTTTTATGTGTTCTTAACCAATTGCCATTGGCTATTCCTGGAAAAGAAGTTTATAAAAAAATTTTTTAT TTCAACATTCGGGTAAAATT
Downstream 100 bases:
>100_bases ATTTTGGCTAAAGGTGAAAAAAAAACACAATATTTTCAACCGCTGAACTTGGGACGGCTGCCTAATAAAGCAGAAATTCT CTCCTTTATTAATGAGAATC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 853; Mature: 853
Protein sequence:
>853_residues MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAKRLNEIAKAVKEADSLILATD PDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKL PGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKA KYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGLITYMRTDGVQIAPEAIDSAR KVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRIPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVE IEAQQGENYANLRATGSVIRFDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKK LEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLR DFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDGSDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLG TDPGEENEAIRNDEPVILGVDPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHP ETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTAALATLGNHPDGGVVTVRNGR YGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKKTTLKRASTKTKET
Sequences:
>Translated_853_residues MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAKRLNEIAKAVKEADSLILATD PDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKL PGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKA KYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGLITYMRTDGVQIAPEAIDSAR KVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRIPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVE IEAQQGENYANLRATGSVIRFDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKK LEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLR DFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDGSDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLG TDPGEENEAIRNDEPVILGVDPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHP ETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTAALATLGNHPDGGVVTVRNGR YGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKKTTLKRASTKTKET >Mature_853_residues MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAKRLNEIAKAVKEADSLILATD PDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKL PGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKA KYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGLITYMRTDGVQIAPEAIDSAR KVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRIPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVE IEAQQGENYANLRATGSVIRFDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKK LEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLR DFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDGSDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLG TDPGEENEAIRNDEPVILGVDPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHP ETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTAALATLGNHPDGGVVTVRNGR YGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKKTTLKRASTKTKET
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=600, Percent_Identity=26.8333333333333, Blast_Score=126, Evalue=9e-29, Organism=Homo sapiens, GI4507635, Length=615, Percent_Identity=22.6016260162602, Blast_Score=110, Evalue=6e-24, Organism=Escherichia coli, GI1787529, Length=671, Percent_Identity=37.8539493293592, Blast_Score=442, Evalue=1e-125, Organism=Escherichia coli, GI1788061, Length=558, Percent_Identity=25.8064516129032, Blast_Score=134, Evalue=3e-32, Organism=Caenorhabditis elegans, GI32563869, Length=575, Percent_Identity=26.2608695652174, Blast_Score=125, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17555378, Length=518, Percent_Identity=27.027027027027, Blast_Score=125, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6323263, Length=571, Percent_Identity=23.4676007005254, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24585251, Length=615, Percent_Identity=27.3170731707317, Blast_Score=149, Evalue=6e-36, Organism=Drosophila melanogaster, GI24640096, Length=575, Percent_Identity=24.3478260869565, Blast_Score=106, Evalue=6e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 95468; Mature: 95468
Theoretical pI: Translated: 8.94; Mature: 8.94
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.6 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAK CEEEEECCCCHHHHHHHHHCCCEEEEEHHCCHHCCCCCCCCCCCCCCCCEEECCCHHHHH RLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSV HHHHHHHHHHHCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH LDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDR HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEEECC ESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKA HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH KYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGL HHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCEEH ITYMRTDGVQIAPEAIDSARKVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQR EEEHCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHH IPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVEIEAQQGENYANLRATGSVIR HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCEEE FDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKK ECCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH LEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTAD HHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC LEEKLDLISDGKLSWKDVLRDFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDG HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC SDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEENEAIRNDEPVILGV CCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEC DPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHP CCCCCCCEEEECCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCC ETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTA CCCCEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH ALATLGNHPDGGVVTVRNGRYGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKK HHHHHCCCCCCCEEEEECCCCCCCEECCCEEECCCCCCCCCEEEHHHHHHHHHCCCCCCH TTLKRASTKTKET HHHHHHCCCCCCC >Mature Secondary Structure MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAK CEEEEECCCCHHHHHHHHHCCCEEEEEHHCCHHCCCCCCCCCCCCCCCCEEECCCHHHHH RLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSV HHHHHHHHHHHCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH LDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDR HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEEECC ESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKA HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH KYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGL HHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCEEH ITYMRTDGVQIAPEAIDSARKVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQR EEEHCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHH IPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVEIEAQQGENYANLRATGSVIR HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEEEECCCEEE FDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKK ECCEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH LEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTAD HHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC LEEKLDLISDGKLSWKDVLRDFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDG HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC SDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEENEAIRNDEPVILGV CCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEC DPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHP CCCCCCCEEEECCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCC ETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTA CCCCEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH ALATLGNHPDGGVVTVRNGRYGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKK HHHHHCCCCCCCEEEEECCCCCCCEECCCEEECCCCCCCCCEEEHHHHHHHHHCCCCCCH TTLKRASTKTKET HHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA