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The map label for this gene is pdxA [H]

Identifier: 49475335

GI number: 49475335

Start: 627563

End: 628576

Strand: Reverse

Name: pdxA [H]

Synonym: BH05410

Alternate gene names: 49475335

Gene position: 628576-627563 (Counterclockwise)

Preceding gene: 49475336

Following gene: 49475334

Centisome position: 32.55

GC content: 40.14

Gene sequence:

>1014_bases
ATGGATGTACTTGTTGTTAGTGGTGGTGATCCTGCCGGAATTGGTCCTGAAATAGCACTAAAAGCGTGGAATTTGCGTGC
CACACGTCAAATTCCGCCTTTTGTTCTTATCGCTGACCCAGATGTTATTCGTGCACGTGCGCATTTCTTACAGATTGACG
TCAAAGTAGAAGCTGTTTTAACAGATAATCCTGTAAAAAACTTCCAAGAAGCTCTTCCCGTAATACCTTTAAAAAACCGG
CAAAGTGATCAACTAGGATTACCTTCACATGAAAATGCTGCTGGAATAATTGAAGCGATCAAACGCGGCGTTCAGTTGAT
TCAAAGTGGTCATGCTTGTGCACTCGTCACTTGTCCTATTGCAAAAAAAAGCCTTTATGATGCTGGATTTGAATTTCCCG
GTCATACAGAGTTGTTAGCCGATTTAGCCCATCAAGCTTCCGATAAATATTATCATCCAGTTATGATGTTATCTGGACCT
CGATTAAAGACCGTGCCTATTACTGTTCATATTCCATTCAAGAAAGTTCCCTCACATCTTACCCACCATTTAATCGTCCA
AACAGCACTCATTACTGAAAAAGACTTAAGAACGCGATTTAAAATAATTTCACCTCGTCTAGCTGTTGCTGGACTTAATC
CTCATGCTGGAGAAGAAGGAGCAATAGGAAAAGAAGATATTGAAATTATCATTCCTGCTATTGAAACTCTTAAAAATAAA
GGACTTAATATTGTAGGTCCCTTGCCTGCCGATACAATGTTCCATGAGTGCGCACGAAAAGCATATGATGTTGCCCTTTG
TATGTATCATGATCAAGCCCTTATCCCTGTTAAGACATTGGACTTTGATACCACTGTCAATATCACTTTAGGGCTCCCAT
TTATTCGTACTTCTCCAGATCATGGAACTGCTTTTGATATTGCTGCTAAAGGGATTGCCTCTCCTGAAAGCTTTATTTCT
GCTCTTAAACTTGCACATCAACTGGCGGAAAATAGTTTTACACCATGCCAATAG

Upstream 100 bases:

>100_bases
CCCTTCAAGATAATAAACAAAAAAGCCCGCAAGAACTTGAAATCTTAAGTGAGAAATATTTAAAAGAATTGCGGCAGGTG
GCGCGTATTAAAAGTTCATA

Downstream 100 bases:

>100_bases
ATAGTCTCCCTCCTCTTCGTGAGGTCATTAATACATATGGATTGCAAGCGCATAAATCCTTAGGCCAAAATTTTCTTTTT
GATCTTAATTTAACATCTAA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MDVLVVSGGDPAGIGPEIALKAWNLRATRQIPPFVLIADPDVIRARAHFLQIDVKVEAVLTDNPVKNFQEALPVIPLKNR
QSDQLGLPSHENAAGIIEAIKRGVQLIQSGHACALVTCPIAKKSLYDAGFEFPGHTELLADLAHQASDKYYHPVMMLSGP
RLKTVPITVHIPFKKVPSHLTHHLIVQTALITEKDLRTRFKIISPRLAVAGLNPHAGEEGAIGKEDIEIIIPAIETLKNK
GLNIVGPLPADTMFHECARKAYDVALCMYHDQALIPVKTLDFDTTVNITLGLPFIRTSPDHGTAFDIAAKGIASPESFIS
ALKLAHQLAENSFTPCQ

Sequences:

>Translated_337_residues
MDVLVVSGGDPAGIGPEIALKAWNLRATRQIPPFVLIADPDVIRARAHFLQIDVKVEAVLTDNPVKNFQEALPVIPLKNR
QSDQLGLPSHENAAGIIEAIKRGVQLIQSGHACALVTCPIAKKSLYDAGFEFPGHTELLADLAHQASDKYYHPVMMLSGP
RLKTVPITVHIPFKKVPSHLTHHLIVQTALITEKDLRTRFKIISPRLAVAGLNPHAGEEGAIGKEDIEIIIPAIETLKNK
GLNIVGPLPADTMFHECARKAYDVALCMYHDQALIPVKTLDFDTTVNITLGLPFIRTSPDHGTAFDIAAKGIASPESFIS
ALKLAHQLAENSFTPCQ
>Mature_337_residues
MDVLVVSGGDPAGIGPEIALKAWNLRATRQIPPFVLIADPDVIRARAHFLQIDVKVEAVLTDNPVKNFQEALPVIPLKNR
QSDQLGLPSHENAAGIIEAIKRGVQLIQSGHACALVTCPIAKKSLYDAGFEFPGHTELLADLAHQASDKYYHPVMMLSGP
RLKTVPITVHIPFKKVPSHLTHHLIVQTALITEKDLRTRFKIISPRLAVAGLNPHAGEEGAIGKEDIEIIIPAIETLKNK
GLNIVGPLPADTMFHECARKAYDVALCMYHDQALIPVKTLDFDTTVNITLGLPFIRTSPDHGTAFDIAAKGIASPESFIS
ALKLAHQLAENSFTPCQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=331, Percent_Identity=37.4622356495468, Blast_Score=209, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 36617; Mature: 36617

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVLVVSGGDPAGIGPEIALKAWNLRATRQIPPFVLIADPDVIRARAHFLQIDVKVEAVL
CEEEEEECCCCCCCCCCCEEEEECCEECCCCCCEEEEECCHHHHHEEEEEEEEEEEEEEE
TDNPVKNFQEALPVIPLKNRQSDQLGLPSHENAAGIIEAIKRGVQLIQSGHACALVTCPI
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
AKKSLYDAGFEFPGHTELLADLAHQASDKYYHPVMMLSGPRLKTVPITVHIPFKKVPSHL
CHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECHHHHHHHH
THHLIVQTALITEKDLRTRFKIISPRLAVAGLNPHAGEEGAIGKEDIEIIIPAIETLKNK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHC
GLNIVGPLPADTMFHECARKAYDVALCMYHDQALIPVKTLDFDTTVNITLGLPFIRTSPD
CCEEECCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCEEEEEECCCEEEECCC
HGTAFDIAAKGIASPESFISALKLAHQLAENSFTPCQ
CCCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDVLVVSGGDPAGIGPEIALKAWNLRATRQIPPFVLIADPDVIRARAHFLQIDVKVEAVL
CEEEEEECCCCCCCCCCCEEEEECCEECCCCCCEEEEECCHHHHHEEEEEEEEEEEEEEE
TDNPVKNFQEALPVIPLKNRQSDQLGLPSHENAAGIIEAIKRGVQLIQSGHACALVTCPI
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
AKKSLYDAGFEFPGHTELLADLAHQASDKYYHPVMMLSGPRLKTVPITVHIPFKKVPSHL
CHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECHHHHHHHH
THHLIVQTALITEKDLRTRFKIISPRLAVAGLNPHAGEEGAIGKEDIEIIIPAIETLKNK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHC
GLNIVGPLPADTMFHECARKAYDVALCMYHDQALIPVKTLDFDTTVNITLGLPFIRTSPD
CCEEECCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCEEEEEECCCEEEECCC
HGTAFDIAAKGIASPESFISALKLAHQLAENSFTPCQ
CCCEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]