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The map label for this gene is hemK [H]

Identifier: 49475008

GI number: 49475008

Start: 265564

End: 266430

Strand: Reverse

Name: hemK [H]

Synonym: BH01960

Alternate gene names: 49475008

Gene position: 266430-265564 (Counterclockwise)

Preceding gene: 49475009

Following gene: 49475003

Centisome position: 13.8

GC content: 38.41

Gene sequence:

>867_bases
ATGAACAAACATTCTCTCAACAATGTCATTCGACAAACTCAAGAAAAATTGCGCTCTCAAGGAGTTTCTGAAGCCAATCT
TGATGCAAAAATACTGGTCGAATGGATAACAGATACAAATATATCTGATAGAGTTCTCCAACCAGATCTTTGCCTCTCTT
TTGAACAAATATTACAATTAGAAAAAGCCATTCAACGACGTATTGCTGGTGAACCTGTCTACCGTATTATCGGAAAACGA
GAGTTTTATGGTATATCCTTCGCACTCTCTCAAGAAACATTAGAACCACGCTCTGATACAGAAACGCTGGTGGATCTTGT
TTTACCACCCCTCAAAAAATATGGTGAAAAATCAGAAAAAATAACACTGCTGGATATGGGAACAGGAAGCGGTGCTATTG
CCATTGCGATTCTTAAACAAATTCCCCAATCCTATGCAGTAGCTGTCGATATTTCTGAAAACGCTCTTAAAACAGCCACA
AAAAATGCAAAAAGTGCGAAAGTTATAAATCGCTTTACACCTCTTCTGAGCGATTGGTTTGATTCTGTTACAGGGCAATT
CGATCTCATTATTTCCAATCCACCCTATATTCCAGAAACAGATATCACAAAGCTTGCAAAGGAAGTACATCTGCATGATC
CCTTGCGCGCATTAATTGGTGGAAAAGATGGTCTTGATTTTTATCGAAAGCTTTCTGACAAAGCAGCAAACTACTTAAAA
GAAAAAGGTTCTATCGCTGTCGAAATCGGCTACTCTCAAGAAAAAGAAGTCTGCGACTTATTTGAAAAAAATGGCTTCAA
ATGTTTAGAAATGCGCAAAGACTTAAACGGTATACCCCGCGCCCTTCTCTTTGTATGTAACCCTTAA

Upstream 100 bases:

>100_bases
ATAAACTTGACCGCGTTTTAGAAGGAGATCTTGATGAACTTATTCATGCACTCATATCCGATCACCAAACAGCCCTCCTT
ATGGAAATGGATCATCATGA

Downstream 100 bases:

>100_bases
AACTCCCAATCATCATCCGTGGTAGCAACCGCCTTGCCAATAACATAAGAAGAGCCAGCTCCTGAAAAAAAATCATGATT
TTCATCAGAGTTTGGTGATA

Product: protoporphyrinogen oxidase protein

Products: NA

Alternate protein names: M.MloHemKP [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNKHSLNNVIRQTQEKLRSQGVSEANLDAKILVEWITDTNISDRVLQPDLCLSFEQILQLEKAIQRRIAGEPVYRIIGKR
EFYGISFALSQETLEPRSDTETLVDLVLPPLKKYGEKSEKITLLDMGTGSGAIAIAILKQIPQSYAVAVDISENALKTAT
KNAKSAKVINRFTPLLSDWFDSVTGQFDLIISNPPYIPETDITKLAKEVHLHDPLRALIGGKDGLDFYRKLSDKAANYLK
EKGSIAVEIGYSQEKEVCDLFEKNGFKCLEMRKDLNGIPRALLFVCNP

Sequences:

>Translated_288_residues
MNKHSLNNVIRQTQEKLRSQGVSEANLDAKILVEWITDTNISDRVLQPDLCLSFEQILQLEKAIQRRIAGEPVYRIIGKR
EFYGISFALSQETLEPRSDTETLVDLVLPPLKKYGEKSEKITLLDMGTGSGAIAIAILKQIPQSYAVAVDISENALKTAT
KNAKSAKVINRFTPLLSDWFDSVTGQFDLIISNPPYIPETDITKLAKEVHLHDPLRALIGGKDGLDFYRKLSDKAANYLK
EKGSIAVEIGYSQEKEVCDLFEKNGFKCLEMRKDLNGIPRALLFVCNP
>Mature_288_residues
MNKHSLNNVIRQTQEKLRSQGVSEANLDAKILVEWITDTNISDRVLQPDLCLSFEQILQLEKAIQRRIAGEPVYRIIGKR
EFYGISFALSQETLEPRSDTETLVDLVLPPLKKYGEKSEKITLLDMGTGSGAIAIAILKQIPQSYAVAVDISENALKTAT
KNAKSAKVINRFTPLLSDWFDSVTGQFDLIISNPPYIPETDITKLAKEVHLHDPLRALIGGKDGLDFYRKLSDKAANYLK
EKGSIAVEIGYSQEKEVCDLFEKNGFKCLEMRKDLNGIPRALLFVCNP

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=281, Percent_Identity=29.1814946619217, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787463, Length=283, Percent_Identity=33.2155477031802, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082085, Length=220, Percent_Identity=33.1818181818182, Blast_Score=106, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24582226, Length=252, Percent_Identity=32.1428571428571, Blast_Score=117, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32255; Mature: 32255

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHSLNNVIRQTQEKLRSQGVSEANLDAKILVEWITDTNISDRVLQPDLCLSFEQILQL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHCCCCCCCCCCCHHHHHHHHHHHH
EKAIQRRIAGEPVYRIIGKREFYGISFALSQETLEPRSDTETLVDLVLPPLKKYGEKSEK
HHHHHHHHCCCHHHHHHCCHHHEEEEEEECHHHCCCCCHHHHHHHHHHHHHHHHCCCCCE
ITLLDMGTGSGAIAIAILKQIPQSYAVAVDISENALKTATKNAKSAKVINRFTPLLSDWF
EEEEEECCCCCHHHHHHHHHCCHHHEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DSVTGQFDLIISNPPYIPETDITKLAKEVHLHDPLRALIGGKDGLDFYRKLSDKAANYLK
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKGSIAVEIGYSQEKEVCDLFEKNGFKCLEMRKDLNGIPRALLFVCNP
HCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHCCCCCHHHEEEECC
>Mature Secondary Structure
MNKHSLNNVIRQTQEKLRSQGVSEANLDAKILVEWITDTNISDRVLQPDLCLSFEQILQL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEHHCCCCCCCCCCCHHHHHHHHHHHH
EKAIQRRIAGEPVYRIIGKREFYGISFALSQETLEPRSDTETLVDLVLPPLKKYGEKSEK
HHHHHHHHCCCHHHHHHCCHHHEEEEEEECHHHCCCCCHHHHHHHHHHHHHHHHCCCCCE
ITLLDMGTGSGAIAIAILKQIPQSYAVAVDISENALKTATKNAKSAKVINRFTPLLSDWF
EEEEEECCCCCHHHHHHHHHCCHHHEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DSVTGQFDLIISNPPYIPETDITKLAKEVHLHDPLRALIGGKDGLDFYRKLSDKAANYLK
HHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKGSIAVEIGYSQEKEVCDLFEKNGFKCLEMRKDLNGIPRALLFVCNP
HCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHCCCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]