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The map label for this gene is ntdR [H]

Identifier: 49186054

GI number: 49186054

Start: 3020718

End: 3021707

Strand: Direct

Name: ntdR [H]

Synonym: BAS3049

Alternate gene names: 49186054

Gene position: 3020718-3021707 (Clockwise)

Preceding gene: 49186045

Following gene: 49186055

Centisome position: 57.77

GC content: 29.19

Gene sequence:

>990_bases
ATGGTAACAATTAATGAAATAGCTAAATTATGTAATGTATCAAATGCTACCGTTTCAAGAGTTCTAAATAATCATCCTTA
TGTAAATTCAGAAAAACGTGAGAAAATAATAAAAGTAATGCAAGAATTCAACTATACTCCTAGTGCTATTGCTAGAAATC
TTAGGATAAATAAGACACAAACCATTGCTCTATCAATTCCAAATATAGATCATCCCTTTTTCGGGAAATTAGCTAGAGAA
ATTTCTAAAGAATTATTAAAACACAATTACAAATTGCTAATTTATCAGACTTTTTATGAGAAAAAAATAGAGCTTGAATT
ACTTTCATTACTAAAGAATAAAGCTGTAGATGGTGTAATTCTCGCATCTCTAGAAAATAGTTGGGAAAATATAGAGCATT
ATTTAGCATATGGGCCCATAATACTTTGTAATGAGTATGAGGAAAATGCACCTATTCCGATAATTTGTTACGATGAATTT
GAAGCTGGATACAAAGCTGTTAAACATTTAATAAGCAAAGGTTATAAAAAAATTGGCTTTTGTTTTGACTCTCTTAATAG
TCAAGCACAATTAAAACGCCAACAAGGTTATCTGCATGCCTTAAAAGAAAAACAATTACCATTCAATAAAAAATGGCTAT
TTGGAGATGCAATTACTATTAATGATGGATTTAAAATTTTTGAGAAGCTAGATAAATTAAAAGATAAACCTACTGCATTA
TTTACTGGAAATGATCAAGTTGCTGCTGGAGTCATTAAAGGAGCTACTATTAGGGGGTATTCTATTCCAAGTGACTTAGC
TGTTTGTGGTTATGATAATCAATTAATTTGTACAGTTACAACCCCAACAATTAGTACTATTGATATTCCAATTGTTGAAC
TGAGTAAACGTACCGTTAAGGAGATACTACTATATATAAATACAGATGAATCTATTAAACGTAAAATTATTGAATACCCT
ACAAACTTAATTATTCGTGAATCTACATAA

Upstream 100 bases:

>100_bases
ACGTTAAATCACCTCTAAGAAATTATTTTGAAAATCATGAGTAGACTATATTTTATGTTATCGATTACATGTCAACATAT
TTTTTACGGAGGGTTTTTCT

Downstream 100 bases:

>100_bases
TTAAATTAAAGTTTTTGCTTAAACTGATGTGATTAATAAAAAGAGGTCGTAAATAATAATGCGTCCTCTTTTTATCGTTT
TAGGTATTAAATTCTACGTA

Product: LacI family sugar-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MVTINEIAKLCNVSNATVSRVLNNHPYVNSEKREKIIKVMQEFNYTPSAIARNLRINKTQTIALSIPNIDHPFFGKLARE
ISKELLKHNYKLLIYQTFYEKKIELELLSLLKNKAVDGVILASLENSWENIEHYLAYGPIILCNEYEENAPIPIICYDEF
EAGYKAVKHLISKGYKKIGFCFDSLNSQAQLKRQQGYLHALKEKQLPFNKKWLFGDAITINDGFKIFEKLDKLKDKPTAL
FTGNDQVAAGVIKGATIRGYSIPSDLAVCGYDNQLICTVTTPTISTIDIPIVELSKRTVKEILLYINTDESIKRKIIEYP
TNLIIREST

Sequences:

>Translated_329_residues
MVTINEIAKLCNVSNATVSRVLNNHPYVNSEKREKIIKVMQEFNYTPSAIARNLRINKTQTIALSIPNIDHPFFGKLARE
ISKELLKHNYKLLIYQTFYEKKIELELLSLLKNKAVDGVILASLENSWENIEHYLAYGPIILCNEYEENAPIPIICYDEF
EAGYKAVKHLISKGYKKIGFCFDSLNSQAQLKRQQGYLHALKEKQLPFNKKWLFGDAITINDGFKIFEKLDKLKDKPTAL
FTGNDQVAAGVIKGATIRGYSIPSDLAVCGYDNQLICTVTTPTISTIDIPIVELSKRTVKEILLYINTDESIKRKIIEYP
TNLIIREST
>Mature_329_residues
MVTINEIAKLCNVSNATVSRVLNNHPYVNSEKREKIIKVMQEFNYTPSAIARNLRINKTQTIALSIPNIDHPFFGKLARE
ISKELLKHNYKLLIYQTFYEKKIELELLSLLKNKAVDGVILASLENSWENIEHYLAYGPIILCNEYEENAPIPIICYDEF
EAGYKAVKHLISKGYKKIGFCFDSLNSQAQLKRQQGYLHALKEKQLPFNKKWLFGDAITINDGFKIFEKLDKLKDKPTAL
FTGNDQVAAGVIKGATIRGYSIPSDLAVCGYDNQLICTVTTPTISTIDIPIVELSKRTVKEILLYINTDESIKRKIIEYP
TNLIIREST

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=329, Percent_Identity=28.2674772036474, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1787948, Length=351, Percent_Identity=26.7806267806268, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=28.3987915407855, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=27.2727272727273, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=27.5641025641026, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789202, Length=300, Percent_Identity=27, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787580, Length=319, Percent_Identity=24.7648902821317, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI48994940, Length=317, Percent_Identity=21.4511041009464, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786268, Length=323, Percent_Identity=25.077399380805, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787906, Length=215, Percent_Identity=22.7906976744186, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=21.9047619047619, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790689, Length=317, Percent_Identity=23.0283911671924, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789456, Length=313, Percent_Identity=22.3642172523962, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37483; Mature: 37483

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTINEIAKLCNVSNATVSRVLNNHPYVNSEKREKIIKVMQEFNYTPSAIARNLRINKTQ
CCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
TIALSIPNIDHPFFGKLAREISKELLKHNYKLLIYQTFYEKKIELELLSLLKNKAVDGVI
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCEE
LASLENSWENIEHYLAYGPIILCNEYEENAPIPIICYDEFEAGYKAVKHLISKGYKKIGF
EEEHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHH
CFDSLNSQAQLKRQQGYLHALKEKQLPFNKKWLFGDAITINDGFKIFEKLDKLKDKPTAL
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHHHHHHHHHCCCCCEE
FTGNDQVAAGVIKGATIRGYSIPSDLAVCGYDNQLICTVTTPTISTIDIPIVELSKRTVK
EECCCCEEHHEECCCEEECCCCCCCCEEECCCCEEEEEEECCCCEEEECHHHHHHHHHHH
EILLYINTDESIKRKIIEYPTNLIIREST
HHHEEECCCHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure
MVTINEIAKLCNVSNATVSRVLNNHPYVNSEKREKIIKVMQEFNYTPSAIARNLRINKTQ
CCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
TIALSIPNIDHPFFGKLAREISKELLKHNYKLLIYQTFYEKKIELELLSLLKNKAVDGVI
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCEE
LASLENSWENIEHYLAYGPIILCNEYEENAPIPIICYDEFEAGYKAVKHLISKGYKKIGF
EEEHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHH
CFDSLNSQAQLKRQQGYLHALKEKQLPFNKKWLFGDAITINDGFKIFEKLDKLKDKPTAL
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEEEECCCHHHHHHHHHHCCCCCEE
FTGNDQVAAGVIKGATIRGYSIPSDLAVCGYDNQLICTVTTPTISTIDIPIVELSKRTVK
EECCCCEEHHEECCCEEECCCCCCCCEEECCCCEEEEEEECCCCEEEECHHHHHHHHHHH
EILLYINTDESIKRKIIEYPTNLIIREST
HHHEEECCCHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]