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The map label for this gene is ycgH [H]

Identifier: 49185913

GI number: 49185913

Start: 2875494

End: 2875883

Strand: Reverse

Name: ycgH [H]

Synonym: BAS2907

Alternate gene names: 49185913

Gene position: 2875883-2875494 (Counterclockwise)

Preceding gene: 49185914

Following gene: 49185912

Centisome position: 55.0

GC content: 34.62

Gene sequence:

>390_bases
TTGGCAAAAATGGCTGTAGAAGATCCGCAAAAAGGATCTTTTCGCATATACTCAAAAAAAGCTTTTGGAAATTGGGCGGG
TTTTAGTCATGGATGGACATATTGGTGTTCTGAACTGCTTATTATGGGCAGCCAGTTAAGTGCGTTAGGAATCTTTTCAC
GCTACTGGTTTCCTAAAATACCGTTATGGATATTTGCTACTATATATGGAGTAGCGGCTATATTAATTATCTTTATAGGG
GTAAAGATATTCGAACGTTTAGAAAAGTGGATGGCTATTATAAAAATCGCTGCTATTATGGGGTTTATTGTAATTGCTAT
TTTAGTTATTTTAGGATTTATAAAGGGTGGTTTATATAAAGCACAAATTCCGCAGAATTTTAAAGACTGA

Upstream 100 bases:

>100_bases
CTTCTTTTTAGGATCCAGTATAGGAATTAAAATAGGTGGTTCGTCAATTATTCTTATTCTTATTTTAACTGGATTTACTA
CTTATATTGTATTTGAAGCA

Downstream 100 bases:

>100_bases
TTCCCAAATGGATTAAAAGGTACTTGGTCCTCTCTAATTTATGCATTTTATGCATTTGGAGGAATCGAAATTATGGGGTT
AATGACAATAAGACTGAAAG

Product: amino acid permease

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIG
VKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD

Sequences:

>Translated_129_residues
MAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIG
VKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD
>Mature_128_residues
AKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGV
KIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYKAQIPQNFKD

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=104, Percent_Identity=37.5, Blast_Score=86, Evalue=6e-19,
Organism=Escherichia coli, GI1786789, Length=103, Percent_Identity=37.8640776699029, Blast_Score=84, Evalue=4e-18,
Organism=Escherichia coli, GI1789017, Length=113, Percent_Identity=35.3982300884956, Blast_Score=80, Evalue=6e-17,
Organism=Escherichia coli, GI87081708, Length=115, Percent_Identity=27.8260869565217, Blast_Score=77, Evalue=4e-16,
Organism=Escherichia coli, GI1788480, Length=116, Percent_Identity=30.1724137931034, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1786602, Length=105, Percent_Identity=35.2380952380952, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI48994972, Length=118, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1790653, Length=110, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=112, Percent_Identity=30.3571428571429, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 14645; Mature: 14514

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKI
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLWIFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
AQIPQNFKD
CCCCCCCCC
>Mature Secondary Structure 
AKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKI
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLWIFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFIKGGLYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
AQIPQNFKD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]