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The map label for this gene is ycgH [H]

Identifier: 49185912

GI number: 49185912

Start: 2874738

End: 2875421

Strand: Reverse

Name: ycgH [H]

Synonym: BAS2906

Alternate gene names: 49185912

Gene position: 2875421-2874738 (Counterclockwise)

Preceding gene: 49185913

Following gene: 49185909

Centisome position: 54.99

GC content: 32.16

Gene sequence:

>684_bases
ATGGGGTTAATGACAATAAGACTGAAAGACCCTAAAGATGCACAAAAATCAGGAAGAGTAATGTTAATGATTTTAACGAT
TATTTACGTAGTCTCTTTAGGGTTGGCAATTATGATGGTTCCATTAAACCAGTTTAATACGAAAGAAAGCCCTTTTGTAA
TAGCATTACAAGACTATAATTTGCCGTATGTGTCATTTATTTTAAATGTAGTATTAATTTTAGCGGGTTTTTCAACATTA
GTTGGTTCATTATTTGCAGTGACAAGTGTACTAATGAACTTAGCTGAAGAAGGTGATGCACCTGCAATGTTTGCTAAAAA
AAATAAGAAAAATATCTCATTCCCAGCCCTAACTCTTATTATAATTGGACTTGGTGCCTCTATCCTTAGTGCTTTATTAC
TACCGAAAAACATATATGAATATGTAACAACTGCAGCTGGATTGATGTTGTTATATACATGGAGTCTCATTCTTCTTTCA
TTTTGGAGATTAATGAATCCAAAAGGTTGGATGCAGATAAAAAGCATTATTGGTCTTATAATGATTGCACTAGCTGTTAG
TGGGACATTATTGCAAAAAACAACGCGTTTTGGTTTCCTAGTGAGCTTGTTGTTTTTAGGAATAGTTATTATTGTTACTA
TAATTGTTCATTTTGTCTCAAGAAAAAGGAATAAAGCTATATGA

Upstream 100 bases:

>100_bases
ACAAATTCCGCAGAATTTTAAAGACTGATTCCCAAATGGATTAAAAGGTACTTGGTCCTCTCTAATTTATGCATTTTATG
CATTTGGAGGAATCGAAATT

Downstream 100 bases:

>100_bases
AGAATCTATCTTTACACAACATGAATAGTATGTGAAAACTAAATAATAGAAGCTATTGAAAAATGATTTGGTAAGTTTGA
AAACCAAAATATAATCCATA

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MGLMTIRLKDPKDAQKSGRVMLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVSFILNVVLILAGFSTL
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALTLIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLS
FWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNKAI

Sequences:

>Translated_227_residues
MGLMTIRLKDPKDAQKSGRVMLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVSFILNVVLILAGFSTL
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALTLIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLS
FWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNKAI
>Mature_226_residues
GLMTIRLKDPKDAQKSGRVMLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVSFILNVVLILAGFSTLV
GSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALTLIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSF
WRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNKAI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786602, Length=238, Percent_Identity=24.7899159663866, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081915, Length=167, Percent_Identity=26.3473053892216, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87081708, Length=220, Percent_Identity=21.8181818181818, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790653, Length=181, Percent_Identity=25.9668508287293, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 25042; Mature: 24911

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLMTIRLKDPKDAQKSGRVMLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYN
CCEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
LPYVSFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALTLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHH
IIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLMTIRLKDPKDAQKSGRVMLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYN
CEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
LPYVSFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALTLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHH
IIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]