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The map label for this gene is dhbC [H]

Identifier: 49185214

GI number: 49185214

Start: 2202837

End: 2204036

Strand: Direct

Name: dhbC [H]

Synonym: BAS2205

Alternate gene names: 49185214

Gene position: 2202837-2204036 (Clockwise)

Preceding gene: 49185213

Following gene: 49185215

Centisome position: 42.13

GC content: 38.08

Gene sequence:

>1200_bases
ATGAATGAATTTACGGCTGTAAAGGAACTGTCAGAAAAATTACTAGAAGATTATAAGACTGAATCTTCATTCTTTTTTGC
TTCACCAACCCGAACGATATTAGCAGAAGGAGAATTTACTACAGTAAAGCATCATGAAATTGAAAGCTTCCCAGAGCTTG
TGCAAGCAGTATTACGTAATGCAAAACAAGCCGGAAATCCGAATCCTATCGTTGTGGGGGCTTTGCCATTTGATCGTAGA
AAAGAAGTCCAACTTATCGTACCAGAATATAGCAGAATTTCTGAGCGTTTACAATTGGATCCAACAAATCATCTTGAAAT
AAATAGGAACTTAACATTCGAAATGACGCCTGTGCCAGATCATGAAGTGTATATGAAAGGTGTGAAGCAAGGAATTGAAA
AAATAAAGGACGGAGATTTAAAGAAAATCGTTCTATCTAGATCGTTAGATGTTAAATCTTCTGGAAAAATTGATAAGCAA
AAACTTCTTCGAGAATTAGCAGAGCATAATAAGCACGGTTATACATTTGCGGTGAATTTACCGAAAGATGAAAACGAGAA
TAGTAAGACGCTAATTGGAGCTAGTCCTGAATTACTTGTTTCACGTCATGGTATGCAAGTGATTTCTAATCCGTTAGCTG
GTTCAAGACCACGTAGTGACGATCCAGTAGAAGATAAAAGAAGAGCGGAGGAATTACTTTCTTCTCCAAAAGATTTGCAT
GAACATGCGGTAGTAGTGGAAGCAGTTGCTGCTGCGCTTCGCCCATACTGTCATACATTATATGTTCCGGAAAAACCATC
TGTTATTCATAGTGAAGCGATGTGGCATTTGTCTACTGAAGTGAAAGGTGAACTAAAGAATCCAAATACTAGTTCTTTAG
AATTAGCAATTGCTCTTCATCCTACGCCAGCAGTTTGCGGAACGCCGATGGAAGAAGCGAGAGAAGCTATTCAAAAAATT
GAGCCATTTGACCGTGAGTTCTTTACAGGAATGTTAGGTTGGAGCGATTTAAATGGAGACGGTGAATGGATTGTTACAAT
TCGTTGTGCTGAAGTACAAGAAAATACACTCCGTTTATATGCAGGTGCTGGAGTTGTTGCTGAGTCAAAACCAGAAGATG
AATTAGCAGAAACATCAGCTAAGTTTCAAACAATGTTGAAAGCTTTAGGGTTAAATGATAGTTCACTTAATGAAAAGTAG

Upstream 100 bases:

>100_bases
TAGCTTCAGATAAAGCGAGTCATATTACAATGCACAATTTATGTGTCGATGGCGGAGCCACATTAGGAGTTTAATAAAAA
ATTTAGGGGGCTACTATACT

Downstream 100 bases:

>100_bases
GGGGCAGAAAGAATGTTAACAGGTTATACAAAATGGCCAAAAGAATTTGCCGATCGCTATCGAGAGGAAGGGTGTTGGCT
TGGGGAAACATTTGGCGGAG

Product: isochorismate synthase DhbC

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNEFTAVKELSEKLLEDYKTESSFFFASPTRTILAEGEFTTVKHHEIESFPELVQAVLRNAKQAGNPNPIVVGALPFDRR
KEVQLIVPEYSRISERLQLDPTNHLEINRNLTFEMTPVPDHEVYMKGVKQGIEKIKDGDLKKIVLSRSLDVKSSGKIDKQ
KLLRELAEHNKHGYTFAVNLPKDENENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH
EHAVVVEAVAAALRPYCHTLYVPEKPSVIHSEAMWHLSTEVKGELKNPNTSSLELAIALHPTPAVCGTPMEEAREAIQKI
EPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVQENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKALGLNDSSLNEK

Sequences:

>Translated_399_residues
MNEFTAVKELSEKLLEDYKTESSFFFASPTRTILAEGEFTTVKHHEIESFPELVQAVLRNAKQAGNPNPIVVGALPFDRR
KEVQLIVPEYSRISERLQLDPTNHLEINRNLTFEMTPVPDHEVYMKGVKQGIEKIKDGDLKKIVLSRSLDVKSSGKIDKQ
KLLRELAEHNKHGYTFAVNLPKDENENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH
EHAVVVEAVAAALRPYCHTLYVPEKPSVIHSEAMWHLSTEVKGELKNPNTSSLELAIALHPTPAVCGTPMEEAREAIQKI
EPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVQENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKALGLNDSSLNEK
>Mature_399_residues
MNEFTAVKELSEKLLEDYKTESSFFFASPTRTILAEGEFTTVKHHEIESFPELVQAVLRNAKQAGNPNPIVVGALPFDRR
KEVQLIVPEYSRISERLQLDPTNHLEINRNLTFEMTPVPDHEVYMKGVKQGIEKIKDGDLKKIVLSRSLDVKSSGKIDKQ
KLLRELAEHNKHGYTFAVNLPKDENENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH
EHAVVVEAVAAALRPYCHTLYVPEKPSVIHSEAMWHLSTEVKGELKNPNTSSLELAIALHPTPAVCGTPMEEAREAIQKI
EPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVQENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKALGLNDSSLNEK

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786809, Length=377, Percent_Identity=37.6657824933687, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=29.8181818181818, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788114, Length=304, Percent_Identity=25.9868421052632, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787518, Length=337, Percent_Identity=27.5964391691395, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=280, Percent_Identity=28.2142857142857, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 44593; Mature: 44593

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFTAVKELSEKLLEDYKTESSFFFASPTRTILAEGEFTTVKHHEIESFPELVQAVLRN
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
AKQAGNPNPIVVGALPFDRRKEVQLIVPEYSRISERLQLDPTNHLEINRNLTFEMTPVPD
HHHCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHEECCCCCCEEECCCEEEEECCCCC
HEVYMKGVKQGIEKIKDGDLKKIVLSRSLDVKSSGKIDKQKLLRELAEHNKHGYTFAVNL
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEC
PKDENENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH
CCCCCCCCCEEECCCHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHAVVVEAVAAALRPYCHTLYVPEKPSVIHSEAMWHLSTEVKGELKNPNTSSLELAIALH
HHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHEECHHHCCCCCCCCCCCEEEEEEEC
PTPAVCGTPMEEAREAIQKIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVQENTLRLY
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEE
AGAGVVAESKPEDELAETSAKFQTMLKALGLNDSSLNEK
ECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNEFTAVKELSEKLLEDYKTESSFFFASPTRTILAEGEFTTVKHHEIESFPELVQAVLRN
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHH
AKQAGNPNPIVVGALPFDRRKEVQLIVPEYSRISERLQLDPTNHLEINRNLTFEMTPVPD
HHHCCCCCCEEEECCCCCCCCCEEEECCCHHHHHHHEECCCCCCEEECCCEEEEECCCCC
HEVYMKGVKQGIEKIKDGDLKKIVLSRSLDVKSSGKIDKQKLLRELAEHNKHGYTFAVNL
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEC
PKDENENSKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLH
CCCCCCCCCEEECCCHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHAVVVEAVAAALRPYCHTLYVPEKPSVIHSEAMWHLSTEVKGELKNPNTSSLELAIALH
HHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHEECHHHCCCCCCCCCCCEEEEEEEC
PTPAVCGTPMEEAREAIQKIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVQENTLRLY
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEE
AGAGVVAESKPEDELAETSAKFQTMLKALGLNDSSLNEK
ECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550523; 9384377 [H]