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The map label for this gene is fabF [H]

Identifier: 49184116

GI number: 49184116

Start: 1148011

End: 1149249

Strand: Direct

Name: fabF [H]

Synonym: BAS1096

Alternate gene names: 49184116

Gene position: 1148011-1149249 (Clockwise)

Preceding gene: 49184115

Following gene: 49184117

Centisome position: 21.96

GC content: 43.1

Gene sequence:

>1239_bases
ATGGAAAAAAAGAGGGTCGTAATTACAGGACTAGGAGCTGTTACACCGGTCGGTACAGATGTTGAAACAGCGTGGGAAAA
CATTAAAAAGGGTGTATCTGGAATCGGACGACTTACAAGAATTGATCCGGAACTATTTCCAGCAAAAGTAGCAGCAGAAA
TTAACGACTTTGAAGTCGAGAAATATATTGATAAAAAAGAAGCGCGCCGTATGGATCGCTTTACACAATATGCAGTAGCA
GCAGCGAAAATGGCAGTTGCAGATGCAAAGCTTGAGATTACAGAAGAAAACGGACCTCGAATTGGTGTATGGATTGGTTC
TGGTATTGGCGGTATGGAAACATACGAAGAACAATTTAAAATTTTTACTGAGAAAGGCCCGCGCCGCGTGAGCCCATTCT
TCGTACCGATGATGATTCCAGATATGGCAGCAGGCCAAGTATCAATCGCAACAGGAGCAAAAGGAATTAACACTTGTTCT
GTAACGGCTTGTGCATCTGGTGCAAACTCAATTGGTGATGCATTTAAAGCGATTCAGCGTGGGGATGCTGATGCAATGAT
TACGGGCGGGGCAGAGGCACCGTTAACAAGTATGGCATTCGCAGGATTTAGCTCAGCGAAAGCATTAACATTCAATGAAG
ACCCAGCAACAGCTTGCCGTCCATTTGATAAAAACCGTAGCGGTTTCGTAATGGGTGAAGGTTCAGGTATTTTAATTCTT
GAAGAATTAGAGCACGCATTAGCTCGTGGTGCTCATATTTATGCGGAAATCGCTGGTTACGGTGCAACTGGTGATGCATT
CCATATTACAATGCCTGCTCCTGGCGGTGAAGGCGGCGTGCGCGCAATGCGTCAAGCTTTAGCGGATGCAGGTCTACAGC
CAGAAGATATTGATTACATTAATGCGCATGGTACAAGTACGGATGCGAATGAAAAGTATGAAACGATGGCAATTAAAGAA
ACGTTCGGTGAGCACGCGTATAAGGTAGCGATCAGCTCAACGAAATCAATGACAGGTCACTTATTAGGAGCAGCAGGTGC
TGTTGAAGCGATCTTCTCTATTAAATCAATTACAGATGGAGTAATTCCTCCAACAATTAACTATGAAACACCAGATCCAG
AATGTGACTTAGATTACGTACCAAATAACGCGAGACATCAAGAAGTAAACGCAGTGTTAAGTAATTCATTAGGATTCGGT
GGTCATAACGCAGTATTAGTATTTAAATCGTATAAATAA

Upstream 100 bases:

>100_bases
TTAATTATACTTGTTGGTTTTGGCGGCGGATTAACATGGGGAGCAGTCGCTCTTCGTTGGGGTAAATAAGGACTGAGAGA
AAAAAAGGAGTGTATTTTGT

Downstream 100 bases:

>100_bases
TAGATAAAATAAGGAGTTTTTTCGCAATATATTGCGAAAAAACTCCTTATTTATTTTTACGCCTTTTTCTCCTTTTGCAT
ATACATAAGAAAAAGGAGGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MEKKRVVITGLGAVTPVGTDVETAWENIKKGVSGIGRLTRIDPELFPAKVAAEINDFEVEKYIDKKEARRMDRFTQYAVA
AAKMAVADAKLEITEENGPRIGVWIGSGIGGMETYEEQFKIFTEKGPRRVSPFFVPMMIPDMAAGQVSIATGAKGINTCS
VTACASGANSIGDAFKAIQRGDADAMITGGAEAPLTSMAFAGFSSAKALTFNEDPATACRPFDKNRSGFVMGEGSGILIL
EELEHALARGAHIYAEIAGYGATGDAFHITMPAPGGEGGVRAMRQALADAGLQPEDIDYINAHGTSTDANEKYETMAIKE
TFGEHAYKVAISSTKSMTGHLLGAAGAVEAIFSIKSITDGVIPPTINYETPDPECDLDYVPNNARHQEVNAVLSNSLGFG
GHNAVLVFKSYK

Sequences:

>Translated_412_residues
MEKKRVVITGLGAVTPVGTDVETAWENIKKGVSGIGRLTRIDPELFPAKVAAEINDFEVEKYIDKKEARRMDRFTQYAVA
AAKMAVADAKLEITEENGPRIGVWIGSGIGGMETYEEQFKIFTEKGPRRVSPFFVPMMIPDMAAGQVSIATGAKGINTCS
VTACASGANSIGDAFKAIQRGDADAMITGGAEAPLTSMAFAGFSSAKALTFNEDPATACRPFDKNRSGFVMGEGSGILIL
EELEHALARGAHIYAEIAGYGATGDAFHITMPAPGGEGGVRAMRQALADAGLQPEDIDYINAHGTSTDANEKYETMAIKE
TFGEHAYKVAISSTKSMTGHLLGAAGAVEAIFSIKSITDGVIPPTINYETPDPECDLDYVPNNARHQEVNAVLSNSLGFG
GHNAVLVFKSYK
>Mature_412_residues
MEKKRVVITGLGAVTPVGTDVETAWENIKKGVSGIGRLTRIDPELFPAKVAAEINDFEVEKYIDKKEARRMDRFTQYAVA
AAKMAVADAKLEITEENGPRIGVWIGSGIGGMETYEEQFKIFTEKGPRRVSPFFVPMMIPDMAAGQVSIATGAKGINTCS
VTACASGANSIGDAFKAIQRGDADAMITGGAEAPLTSMAFAGFSSAKALTFNEDPATACRPFDKNRSGFVMGEGSGILIL
EELEHALARGAHIYAEIAGYGATGDAFHITMPAPGGEGGVRAMRQALADAGLQPEDIDYINAHGTSTDANEKYETMAIKE
TFGEHAYKVAISSTKSMTGHLLGAAGAVEAIFSIKSITDGVIPPTINYETPDPECDLDYVPNNARHQEVNAVLSNSLGFG
GHNAVLVFKSYK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=46.5060240963855, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=50.6024096385542, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI41872631, Length=432, Percent_Identity=25.462962962963, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=50.6082725060827, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=38.755980861244, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=37.378640776699, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=42.3529411764706, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=27.0718232044199, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=23.9808153477218, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=37.9464285714286, Blast_Score=265, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=44.0191387559809, Blast_Score=344, Evalue=6e-95,
Organism=Drosophila melanogaster, GI19920632, Length=430, Percent_Identity=26.046511627907, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221330659, Length=430, Percent_Identity=26.046511627907, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24581345, Length=431, Percent_Identity=24.5939675174014, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43703; Mature: 43703

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKRVVITGLGAVTPVGTDVETAWENIKKGVSGIGRLTRIDPELFPAKVAAEINDFEVE
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHCCHHHHHCCCHHHHH
KYIDKKEARRMDRFTQYAVAAAKMAVADAKLEITEENGPRIGVWIGSGIGGMETYEEQFK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
IFTEKGPRRVSPFFVPMMIPDMAAGQVSIATGAKGINTCSVTACASGANSIGDAFKAIQR
HHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHC
GDADAMITGGAEAPLTSMAFAGFSSAKALTFNEDPATACRPFDKNRSGFVMGEGSGILIL
CCCCEEEECCCCCCHHHHHHCCCCCCEEEEECCCCCHHCCCCCCCCCEEEEECCCCEEEH
EELEHALARGAHIYAEIAGYGATGDAFHITMPAPGGEGGVRAMRQALADAGLQPEDIDYI
HHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEE
NAHGTSTDANEKYETMAIKETFGEHAYKVAISSTKSMTGHLLGAAGAVEAIFSIKSITDG
ECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIPPTINYETPDPECDLDYVPNNARHQEVNAVLSNSLGFGGHNAVLVFKSYK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MEKKRVVITGLGAVTPVGTDVETAWENIKKGVSGIGRLTRIDPELFPAKVAAEINDFEVE
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHCCHHHHHCCCHHHHH
KYIDKKEARRMDRFTQYAVAAAKMAVADAKLEITEENGPRIGVWIGSGIGGMETYEEQFK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
IFTEKGPRRVSPFFVPMMIPDMAAGQVSIATGAKGINTCSVTACASGANSIGDAFKAIQR
HHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHC
GDADAMITGGAEAPLTSMAFAGFSSAKALTFNEDPATACRPFDKNRSGFVMGEGSGILIL
CCCCEEEECCCCCCHHHHHHCCCCCCEEEEECCCCCHHCCCCCCCCCEEEEECCCCEEEH
EELEHALARGAHIYAEIAGYGATGDAFHITMPAPGGEGGVRAMRQALADAGLQPEDIDYI
HHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEE
NAHGTSTDANEKYETMAIKETFGEHAYKVAISSTKSMTGHLLGAAGAVEAIFSIKSITDG
ECCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VIPPTINYETPDPECDLDYVPNNARHQEVNAVLSNSLGFGGHNAVLVFKSYK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]