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The map label for this gene is fabH1

Identifier: 49184115

GI number: 49184115

Start: 1147047

End: 1147979

Strand: Direct

Name: fabH1

Synonym: BAS1095

Alternate gene names: 49184115

Gene position: 1147047-1147979 (Clockwise)

Preceding gene: 49184114

Following gene: 49184116

Centisome position: 21.94

GC content: 40.73

Gene sequence:

>933_bases
GTGAACGTGGGCATTTTAGGGATCGGAAGATATGTGCCGGAAAAAGTAGTCACAAATCACGATTTAGAAAAAATAATGGA
TACATCCGATGAATGGATTCGTACGAGAACAGGTATTGCGGAAAGACGCATTGCCGATGATACAATAGATACTTCATATA
TGGCCGTAGAGGCTTCTAAAAAAGCACTTGAAGATGCAGGGATTAGCGGAGAGGATATCGATCTTATTTTAGTAGCAACA
GTAACGCCAGATCGTGCTTTTCCAGCAGTAGCTTGTGTTATTCAAGAAGCAATTGGCGCAAAACATGCAGCTGCAATGGA
TTTAAGTGCAGCGTGTGCTGGTTTTATGTACGGAATGATTACAGCGCAGCAATTTATTCAAACGGGAACTTATAAAAATG
TACTAGTAGTTGGTAGTGATAAGCTATCTAAAATTGTAGACTGGAACGATCGAAATACAGCAGTACTATTTGGAGACGGA
GCCGGTGCGATCGTAATGGGAGCTGTTTCAGAAGGTAAAGGCGTTCTATCTTTCGAATTAGGAGCGGACGGAAGTGGCGG
TAAGCATCTTTATCAAGACGAGTATGTTATGATGAATGGCAGAGAAGTCTTTAAATTTGCTGTTCGTCAACTTGGGGATT
CTTGTCTTCGCGTTTTAGATAAAGCTGGTCTTACGAAAGAAGATGTGGATTTCTTAGTACCGCATCAAGCGAACATTCGT
ATTATGGAATCTGCAAGAGAGAGATTAAATTTACCACAAGAAAAAATGAGTATGACAATTGAGAAGTTCGGTAATACATC
AGCTTCTTCCATTCCGATTGCAATGGTAGAGGAATTGCAAAATGGACGTATTCAAGATGGTGATTTAATTATACTTGTTG
GTTTTGGCGGCGGATTAACATGGGGAGCAGTCGCTCTTCGTTGGGGTAAATAA

Upstream 100 bases:

>100_bases
GCTTTATGTTTTAGCTGAAATATATTCTAGACAAAAATACATTTATGTTTTAAAATTAGTACCAAGTCATAATAATTGAT
ATAAAACGGAGGGCTGCGAT

Downstream 100 bases:

>100_bases
GGACTGAGAGAAAAAAAGGAGTGTATTTTGTATGGAAAAAAAGAGGGTCGTAATTACAGGACTAGGAGCTGTTACACCGG
TCGGTACAGATGTTGAAACA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Beta-ketoacyl-ACP synthase III 1; KAS III 1

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK

Sequences:

>Translated_310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK
>Mature_310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=45.2830188679245, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH1_BACAN (Q81JG0)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_843661.1
- RefSeq:   YP_017796.1
- RefSeq:   YP_027367.1
- ProteinModelPortal:   Q81JG0
- SMR:   Q81JG0
- EnsemblBacteria:   EBBACT00000013265
- EnsemblBacteria:   EBBACT00000013953
- EnsemblBacteria:   EBBACT00000020184
- GeneID:   1089235
- GeneID:   2815277
- GeneID:   2851531
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1184
- KEGG:   bar:GBAA_1184
- KEGG:   bat:BAS1095
- TIGR:   BA_1184
- TIGR:   GBAA_1184
- GeneTree:   EBGT00050000001269
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- ProtClustDB:   PRK09352
- BioCyc:   BANT260799:BAS1095-MONOMER
- BioCyc:   BANT261594:GBAA1184-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33454; Mature: 33454

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 235-235 ACT_SITE 265-265

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASK
CCEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEHHHH
KALEDAGISGEDIDLILVATVTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMI
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDGAGAIVMGAVSEGKGVLSFEL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEE
GADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
CCCCCCCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEECCCCCCEE
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLT
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCC
WGAVALRWGK
CHHEEEECCC
>Mature Secondary Structure
MNVGILGIGRYVPEKVVTNHDLEKIMDTSDEWIRTRTGIAERRIADDTIDTSYMAVEASK
CCEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEHHHH
KALEDAGISGEDIDLILVATVTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMI
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDGAGAIVMGAVSEGKGVLSFEL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEE
GADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
CCCCCCCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEECCCCCCEE
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLT
EHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCC
WGAVALRWGK
CHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629