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The map label for this gene is aceA [H]

Identifier: 49184072

GI number: 49184072

Start: 1106182

End: 1107459

Strand: Direct

Name: aceA [H]

Synonym: BAS1052

Alternate gene names: 49184072

Gene position: 1106182-1107459 (Clockwise)

Preceding gene: 49184071

Following gene: 49184074

Centisome position: 21.16

GC content: 43.11

Gene sequence:

>1278_bases
ATGAAAAACGAAAGAATCGAGAAATTACAAGAGAGCTGGGAATTAGATACGCGTTGGAAAGGGATTACACGTCCATATTC
GGCAGAAGATGTAATTCGCCTGCGCGGATCAATTGATATCGAGCATACATTAGCGCGCCGCGGTGCTGAAAAGCTTTGGG
CATCGCTTCATACAGAAGATTACATTAACGCACTTGGGGCATTAACAGGAAACCAAGCGATGCAACAAGTAAAAGCTGGG
TTAAAAGCAATTTATTTAAGTGGATGGCAAGTAGCGGCCGATGCAAACCTGTCTGGACATATGTATCCAGACCAAAGTTT
ATATCCAGCGAACAGCGTACCTGCTGTCGTAAAACGAATTAATCAAACACTTCAACGTGCGGATCAAATTCAGCATATGG
AAGGAAGCGGTGATACAGATTATTTCGTGCCAATTGTAGCAGATGCAGAAGCTGGATTTGGCGGACAATTAAACGTATTT
GAACTGATGAAAGGTATGATTGAAGCGGGTGCGTCTGGCGTGCACTTTGAAGATCAATTATCTTCAGAGAAGAAATGCGG
TCATTTAGGCGGAAAAGTATTACTACCAACGCAAACAGCAGTGCGTAATTTAATTTCGGCACGCCTTGCTGCAGACGTAA
TGGGAGTGCCGACAATTATCGTTGCAAGAACAGATGCGGATGCAGCAGATTTAATTACGAGCGATATCGATCCTGTTGAT
AAAGCGTTTATTACAGGAGAAAGAACACCAGAAGGATTTTACCGTACGAAAGCAGGTCTTGACCAAGCGATTGCACGTGG
TTTAGCGTACGCTCCTTACGCAGACCTCGTTTGGTGTGAAACTTCAGAACCAAATTTAGAAGATGCAAAACGATTTGCGG
ACGCAATTCATAAGGAGCATCCAGGGAAGCTACTTGCATATAACTGCTCACCTTCATTCAACTGGAAACAAAAACTAGAT
GAAAAAACAATTGCAAGCTTCCAAAAGGAAATCGCATCTTACGGTTACAAGTTCCAATTCGTAACACTTGCTGGATTCCA
TTCATTAAATTACGGTATGTTTGAACTAGCACGTGGCTATAAAGAGCGCGGCATGGCAGCATACTCTGAACTACAACAAG
CAGAATTCGCAGCTGAAAAACACGGCTACTCTGCAACACGTCATCAACGCGAAGTAGGAACAGGTTACTTTGATGAAGTG
GCACAAGTGATTACAGGCGGAACTTCATCAACGACAGCGTTAAAAGGATCTACAGAAGAAGCACAGTTTACGAAATAA

Upstream 100 bases:

>100_bases
CAACGTTGTTTACAAATCTCGTTCGGAATGATGAATTCGTACCATTTTTAACATTACCAGGTTATGAAATTTTATAAAAA
GTGAAAAGGGGATGGAACAA

Downstream 100 bases:

>100_bases
AAGGAAGGGGCACCTTTTGAAATGGTGTCCCTTGTTATTTTTTGAACGATGCGAGAGTAAATGAAAATATATTAACGATT
TTTTCGATATATCTACCGTA

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKNERIEKLQESWELDTRWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWASLHTEDYINALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPANSVPAVVKRINQTLQRADQIQHMEGSGDTDYFVPIVADAEAGFGGQLNVF
ELMKGMIEAGASGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVPTIIVARTDADAADLITSDIDPVD
KAFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNLEDAKRFADAIHKEHPGKLLAYNCSPSFNWKQKLD
EKTIASFQKEIASYGYKFQFVTLAGFHSLNYGMFELARGYKERGMAAYSELQQAEFAAEKHGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK

Sequences:

>Translated_425_residues
MKNERIEKLQESWELDTRWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWASLHTEDYINALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPANSVPAVVKRINQTLQRADQIQHMEGSGDTDYFVPIVADAEAGFGGQLNVF
ELMKGMIEAGASGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVPTIIVARTDADAADLITSDIDPVD
KAFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNLEDAKRFADAIHKEHPGKLLAYNCSPSFNWKQKLD
EKTIASFQKEIASYGYKFQFVTLAGFHSLNYGMFELARGYKERGMAAYSELQQAEFAAEKHGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK
>Mature_425_residues
MKNERIEKLQESWELDTRWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWASLHTEDYINALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPANSVPAVVKRINQTLQRADQIQHMEGSGDTDYFVPIVADAEAGFGGQLNVF
ELMKGMIEAGASGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVPTIIVARTDADAADLITSDIDPVD
KAFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNLEDAKRFADAIHKEHPGKLLAYNCSPSFNWKQKLD
EKTIASFQKEIASYGYKFQFVTLAGFHSLNYGMFELARGYKERGMAAYSELQQAEFAAEKHGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=432, Percent_Identity=68.9814814814815, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI1786525, Length=267, Percent_Identity=27.7153558052434, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=64.8910411622276, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=64.8910411622276, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=38.0622837370242, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=254, Percent_Identity=38.9763779527559, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46781; Mature: 46781

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNERIEKLQESWELDTRWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWASLHTED
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YINALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLSGHMYPDQSLYPANSVPAVVKRI
HHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
NQTLQRADQIQHMEGSGDTDYFVPIVADAEAGFGGQLNVFELMKGMIEAGASGVHFEDQL
HHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
SSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVPTIIVARTDADAADLITSDIDPVD
CCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCHHH
KAFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNLEDAKRFADAIHKEH
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
PGKLLAYNCSPSFNWKQKLDEKTIASFQKEIASYGYKFQFVTLAGFHSLNYGMFELARGY
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCCHHHHHHHHH
KERGMAAYSELQQAEFAAEKHGYSATRHQREVGTGYFDEVAQVITGGTSSTTALKGSTEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCC
AQFTK
CCCCC
>Mature Secondary Structure
MKNERIEKLQESWELDTRWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWASLHTED
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YINALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLSGHMYPDQSLYPANSVPAVVKRI
HHHHHHHHCCHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
NQTLQRADQIQHMEGSGDTDYFVPIVADAEAGFGGQLNVFELMKGMIEAGASGVHFEDQL
HHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
SSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVPTIIVARTDADAADLITSDIDPVD
CCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCCHHH
KAFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNLEDAKRFADAIHKEH
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
PGKLLAYNCSPSFNWKQKLDEKTIASFQKEIASYGYKFQFVTLAGFHSLNYGMFELARGY
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCCHHHHHHHHH
KERGMAAYSELQQAEFAAEKHGYSATRHQREVGTGYFDEVAQVITGGTSSTTALKGSTEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCC
AQFTK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]