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The map label for this gene is mrdB [H]

Identifier: 49183988

GI number: 49183988

Start: 1021136

End: 1022386

Strand: Direct

Name: mrdB [H]

Synonym: BAS0966

Alternate gene names: 49183988

Gene position: 1021136-1022386 (Clockwise)

Preceding gene: 49183987

Following gene: 49183990

Centisome position: 19.53

GC content: 35.49

Gene sequence:

>1251_bases
TTGAATAAAAAAGGGGAGCGTTTTTTAAAAGAAGTTACGAACCATATTAAATCAAAAGAAGCGAAGGACTTGGTGGCAGC
GGAACTAGACTTTCACTTAAAACAGACGAAGAATATGTGGATAGGGAAAGGATTAAGTGAGGAAATTGCTGAAGATAAGG
CTGTTGAGCAAATGGGGAGTCCGATTAAACTGGGACAAGAACTTAACAAACTGCATAAGCCAAAGGTTGATTGGTTCTTA
CTTATTTTATTAGTGGCTGCGATGGGGTTAGGGTTTTTGCCAATAATCGCTCTTGGGCATACGAATGATTTACTAATGAA
CAAAATAATTTTTGTGACTCTTGGAATTGCCACAGCTATTGGGATGATGTTGCTTGATTACCGGAAGCTAGAAAGACTCG
GGTGGCTGTTTTATACAATTGGAATACTTATCTTGTTAGCTATAAAATGTTTTCCGACTGGTTACGTGATTGGGGAAGCA
ATAATAAAAATTGGCCCCATCAAAATTGATTGTTTAATGACGATACCATTCTTCTTTCTAGCTTGGACTTCTTTTTTCAA
TAATAGTAGGTTAAAGTTTATGCATCTTCTTATGTTGTACGTATTTTCTTTATATCTATTTTCAACTACAGCAATTCTTT
TACACATTTTCATCTATATTACGATGGTATTCGTTATGCTTTGGTGGAGTAAGTTAGGAAAGAAAACGGCATGGCTCATT
ACGATTTTACCCATTTTACCATTGATTATTAGGGATCTATTTTCCTGGTCTGCGGTAAAAGAATATCGGATAGCTAGAAT
TTTAGGATTTATAAACCCAGCGCATGATCAATGGGATTTACGTTTACAAGAGGCGATGTCTTCAGCAGGTTGGTTTGGTA
CATATGGAAATATAAAGTCTATCCCCGCTACCCATACTGATTTTGTATTTGCGAGTTTGACTTACTATTATGGATATGTG
CTTGCGTTAATTATTGTCTTCATTCTTTCTCTTTTTGCAGTAAGAATAATGAACATAGCTTATAAAATAAATGACGGTTA
TGGTAAATTGCTCCTCGTTGGTGGAGTGACTCTTTTTATAATCCATTGTATTTGTAACGTTGGCATGATCCTCGGGATAT
TACCACGTTTTTCTATATCATTACCTTTTATTAGTTATGGGTTAGTACCAACTCTATTTCATGCATTTATAATGGGAATC
GTACTAAGTGTATATCGACGTAAAGACATTCCAGCGAGAAAATCAGCTTAA

Upstream 100 bases:

>100_bases
CAATTAAATGATAAAGGAAACAAGATGCTGCGAAAGGCAGAGAAGAATGCTACGAAGGCACGATTTATATTAAAAGGCTT
AGTACAGGAGTGAGAAAAAA

Downstream 100 bases:

>100_bases
AAAACAAACCACCTAGTCCCTATATTTTTTAGGGTGTAGGTGGTTTTATTTACACACTTAACAAGTTTTTCCGTTCTCAA
CTTCTCCGCATGAATCTGGA

Product: cell cycle protein FtsW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNKKGERFLKEVTNHIKSKEAKDLVAAELDFHLKQTKNMWIGKGLSEEIAEDKAVEQMGSPIKLGQELNKLHKPKVDWFL
LILLVAAMGLGFLPIIALGHTNDLLMNKIIFVTLGIATAIGMMLLDYRKLERLGWLFYTIGILILLAIKCFPTGYVIGEA
IIKIGPIKIDCLMTIPFFFLAWTSFFNNSRLKFMHLLMLYVFSLYLFSTTAILLHIFIYITMVFVMLWWSKLGKKTAWLI
TILPILPLIIRDLFSWSAVKEYRIARILGFINPAHDQWDLRLQEAMSSAGWFGTYGNIKSIPATHTDFVFASLTYYYGYV
LALIIVFILSLFAVRIMNIAYKINDGYGKLLLVGGVTLFIIHCICNVGMILGILPRFSISLPFISYGLVPTLFHAFIMGI
VLSVYRRKDIPARKSA

Sequences:

>Translated_416_residues
MNKKGERFLKEVTNHIKSKEAKDLVAAELDFHLKQTKNMWIGKGLSEEIAEDKAVEQMGSPIKLGQELNKLHKPKVDWFL
LILLVAAMGLGFLPIIALGHTNDLLMNKIIFVTLGIATAIGMMLLDYRKLERLGWLFYTIGILILLAIKCFPTGYVIGEA
IIKIGPIKIDCLMTIPFFFLAWTSFFNNSRLKFMHLLMLYVFSLYLFSTTAILLHIFIYITMVFVMLWWSKLGKKTAWLI
TILPILPLIIRDLFSWSAVKEYRIARILGFINPAHDQWDLRLQEAMSSAGWFGTYGNIKSIPATHTDFVFASLTYYYGYV
LALIIVFILSLFAVRIMNIAYKINDGYGKLLLVGGVTLFIIHCICNVGMILGILPRFSISLPFISYGLVPTLFHAFIMGI
VLSVYRRKDIPARKSA
>Mature_416_residues
MNKKGERFLKEVTNHIKSKEAKDLVAAELDFHLKQTKNMWIGKGLSEEIAEDKAVEQMGSPIKLGQELNKLHKPKVDWFL
LILLVAAMGLGFLPIIALGHTNDLLMNKIIFVTLGIATAIGMMLLDYRKLERLGWLFYTIGILILLAIKCFPTGYVIGEA
IIKIGPIKIDCLMTIPFFFLAWTSFFNNSRLKFMHLLMLYVFSLYLFSTTAILLHIFIYITMVFVMLWWSKLGKKTAWLI
TILPILPLIIRDLFSWSAVKEYRIARILGFINPAHDQWDLRLQEAMSSAGWFGTYGNIKSIPATHTDFVFASLTYYYGYV
LALIIVFILSLFAVRIMNIAYKINDGYGKLLLVGGVTLFIIHCICNVGMILGILPRFSISLPFISYGLVPTLFHAFIMGI
VLSVYRRKDIPARKSA

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786277, Length=141, Percent_Identity=32.6241134751773, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786853, Length=342, Percent_Identity=22.5146198830409, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 47326; Mature: 47326

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKGERFLKEVTNHIKSKEAKDLVAAELDFHLKQTKNMWIGKGLSEEIAEDKAVEQMGS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCC
PIKLGQELNKLHKPKVDWFLLILLVAAMGLGFLPIIALGHTNDLLMNKIIFVTLGIATAI
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GMMLLDYRKLERLGWLFYTIGILILLAIKCFPTGYVIGEAIIKIGPIKIDCLMTIPFFFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEHHHHHHHHHHH
AWTSFFNNSRLKFMHLLMLYVFSLYLFSTTAILLHIFIYITMVFVMLWWSKLGKKTAWLI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TILPILPLIIRDLFSWSAVKEYRIARILGFINPAHDQWDLRLQEAMSSAGWFGTYGNIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
IPATHTDFVFASLTYYYGYVLALIIVFILSLFAVRIMNIAYKINDGYGKLLLVGGVTLFI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
IHCICNVGMILGILPRFSISLPFISYGLVPTLFHAFIMGIVLSVYRRKDIPARKSA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNKKGERFLKEVTNHIKSKEAKDLVAAELDFHLKQTKNMWIGKGLSEEIAEDKAVEQMGS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCC
PIKLGQELNKLHKPKVDWFLLILLVAAMGLGFLPIIALGHTNDLLMNKIIFVTLGIATAI
CHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
GMMLLDYRKLERLGWLFYTIGILILLAIKCFPTGYVIGEAIIKIGPIKIDCLMTIPFFFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEHHHHHHHHHHH
AWTSFFNNSRLKFMHLLMLYVFSLYLFSTTAILLHIFIYITMVFVMLWWSKLGKKTAWLI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TILPILPLIIRDLFSWSAVKEYRIARILGFINPAHDQWDLRLQEAMSSAGWFGTYGNIKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
IPATHTDFVFASLTYYYGYVLALIIVFILSLFAVRIMNIAYKINDGYGKLLLVGGVTLFI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
IHCICNVGMILGILPRFSISLPFISYGLVPTLFHAFIMGIVLSVYRRKDIPARKSA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]