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The map label for this gene is malR [H]

Identifier: 49183572

GI number: 49183572

Start: 586291

End: 586998

Strand: Direct

Name: malR [H]

Synonym: BAS0546

Alternate gene names: 49183572

Gene position: 586291-586998 (Clockwise)

Preceding gene: 49183571

Following gene: 49183573

Centisome position: 11.21

GC content: 32.06

Gene sequence:

>708_bases
ATGATTAAAGTTTTAATTGTAGAAGATGACCCGATGGTAGCAATGCTAAATACGCATTATTTAGAGCAAGTAGGAGGATT
TGAACTTGTTCAAGCAGTTAATTCCATAAAATCGGCGATAGAAGTATTAGAGGAATCACGAATAGATTTAGTCTTACTTG
ATATTTTTATGCCTGAAGAGACTGGATTTGAGCTTTTAATGTATATTCGGAATCAAGAAAAAGAAATCGATATTATGATG
ATTTCAGCTGTACATGATATGGGGAGTATTAAAAAAGCATTACAATATGGCGTAGTAGATTATTTAATTAAACCATTTAC
ATTTGAACGATTTAAAGAGGCATTAACTATATATCGAGAAAAACTTACTTTCATGAAAGAACAACAAAAAATTAGTCAAT
CGGAATTAGATTCGTTAATTTTACAAAAAGAAAAAAGGGAGCCTACTGTCACGAAAGAGCTTCCGAAAGGGTTAACGAAG
CAAACGTTGCAATTAATTTGGCAGAAGATCGAGTCGTTGAATGGAAGAGTGTTTACAACAGATGAAATGGCACAATTAGT
TGGAATTTCAAGAGTTTCTATTCGAAAATATGTAATGTTTTTGACTGACATTGGGGTGTTAGAAAACGAAATGATGTACC
AACATGTGGGAAGACCTGTAAGTAAATTAAGATGTGTTGATCAAAAGAAAATAGAGTTTTACGTATAA

Upstream 100 bases:

>100_bases
GTATACAGCGAATAAATGGGGAAATTCATATGCATTCATTAGTAGGTAAGGGAACAACGATAACAATTGAAATACCTAAA
GGTAGGGATGAGAGGCAAAT

Downstream 100 bases:

>100_bases
GCGACTTAATATAAGTCGCTTATACTTTTTTTAATTACAAAATCAATTACAAAACTTACAAAAACTATTTTTACTATTGA
AAGCGTTTTAATATTGTTAT

Product: response regulator

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSIKSAIEVLEESRIDLVLLDIFMPEETGFELLMYIRNQEKEIDIMM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRVFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVDQKKIEFYV

Sequences:

>Translated_235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSIKSAIEVLEESRIDLVLLDIFMPEETGFELLMYIRNQEKEIDIMM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRVFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVDQKKIEFYV
>Mature_235_residues
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSIKSAIEVLEESRIDLVLLDIFMPEETGFELLMYIRNQEKEIDIMM
ISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYREKLTFMKEQQKISQSELDSLILQKEKREPTVTKELPKGLTK
QTLQLIWQKIESLNGRVFTTDEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVDQKKIEFYV

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=226, Percent_Identity=43.3628318584071, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786838, Length=218, Percent_Identity=28.8990825688073, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27366; Mature: 27366

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSIKSAIEVLEESRIDLVLLDIFMPEE
CEEEEEECCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
TGFELLMYIRNQEKEIDIMMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYRE
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLTFMKEQQKISQSELDSLILQKEKREPTVTKELPKGLTKQTLQLIWQKIESLNGRVFTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEH
DEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVDQKKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCEECC
>Mature Secondary Structure
MIKVLIVEDDPMVAMLNTHYLEQVGGFELVQAVNSIKSAIEVLEESRIDLVLLDIFMPEE
CEEEEEECCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
TGFELLMYIRNQEKEIDIMMISAVHDMGSIKKALQYGVVDYLIKPFTFERFKEALTIYRE
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLTFMKEQQKISQSELDSLILQKEKREPTVTKELPKGLTKQTLQLIWQKIESLNGRVFTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEH
DEMAQLVGISRVSIRKYVMFLTDIGVLENEMMYQHVGRPVSKLRCVDQKKIEFYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]