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The map label for this gene is thrS

Identifier: 46447649

GI number: 46447649

Start: 2393020

End: 2394972

Strand: Reverse

Name: thrS

Synonym: pc2015

Alternate gene names: 46447649

Gene position: 2394972-2393020 (Counterclockwise)

Preceding gene: 46447651

Following gene: 46447648

Centisome position: 99.19

GC content: 36.35

Gene sequence:

>1953_bases
GTGATAAGGAATAACAAATCCATGTTTATTAAATTGAAAGATCAATCATCTTATGAAATGCCCTCTGGAAGCACCGCTAA
AGATCTAGCAGATAAATTGAATTTGAAAGGGCCACATGAAGCTTTAGGAGCTTCTATCAATGGAAAAACAGTTGATCTTT
CTTATCCTTTACAAGAAGGGGATCAGGTTATTTTATGGGGTTTTAACGATCCTGAAGGAAAAGAAATTTTTTGGCACACT
TCTGCTCATGTTCTCGCACAAGCTATTTTACGTTTATGGCCAGATGCACAGCCAACTATTGGACCCCCTATTGAAAATGG
TTTTTACTACGATTTTGCCAATTTGACCATTTCTGATGCCGATTTTGAAAAAATTGAAAAAGAAATGCAGGCTATTATTT
CTGAAAATTTTCAAATCAAACGAGAAGTTATTTCAACAAAATCCGATGCATTAAAACAATTTCAGAATAATCCTTATAAG
TGTGAATTGATTAACAGTTTTGAAGACGAAAGCACATTAACAGGTTATCGGCAAGGCGAGTTTTATGATCTTTGTCGAGG
CCCCCATCTCTTTAATTTAGGAAAAATAAAAGCTCTAAAATTAATGAAAACAGCTGGAGCTTATTGGAGAGGAGATTCTA
ATAAAGAAATGCTTACGCGCATTTACGCCATTTCTTTTCCGGATCGAAAACTTTTAAAAGATTATTTACATCAATTAGAA
GAAGCTAAAAAACGTGATCACAAATTATTAGGGGCGAAATTAGATTTATTTTCCTTAAAAGAAGAGGCTCCTGGAATGCC
TTTTATCCACCCTAAAGGTTTAATTGTTTGGAATCAATTGGTTGCTTACATTAGAGAATGTCTCAGCCGCCACGATTATA
TTGAGATCAAAACACCAACAATGATGACAAAAGAGTTGTGGGAAATTTCTGGTCATTGGGGTAATTATCGTCAAAATATG
TTTATCTCACAAATTGAAGATCGTGATTTTGCCATTAAACCAATGAATTGTCCAGGTTGTATGCTTTATTATAAAAGCCA
TACGCATAGTTATCGTGAACTACCTTTAAGGATAGCTGAAATCGGAAATGTTCATCGCTATGAACCCTCAGGATCTTTAT
CAGGATTATTTAGAGTACGTAGCTTTCACCAAGATGATGCTCACATTTTTATGAAACCGTCCGATATCCAACAAGAAATT
TTAGGAGTACTGGCTCTTGCAGATGAAATCTATTCTACATTTGGTCTTTCTTATCGCTTAGAATTATCGACTCGTCCTGA
AAAAAACACTATTGGTACTGATCATGAATGGGAAGTAGCGACAGCAGGGCTAAAAGGCGCTCTAGATGAAATGGGAAAAG
AATATCGCATTAATGAAGGAGATGGGGCCTTTTATGGACCTAAAATTGACTTTCATATTCGTGACGCAATCAATCGTAGT
TGGCAATGTGGAACTATTCAGCTAGATATGGCTCTACCTGAAAAATTTGAACTCGAATACACTTTTTCGGATGGAACTCG
CCAGCGCCCTGTTATGATTCACCGCGCAATATTTGGCTCAATCGAACGTTTTTTTGGTATTTTAATCGAACATTATGTAG
GTAAATTTCCTCTTTGGTTAAGCCCTTCACAAATCCGATTCATTACGGTCGCTGATCGCCACGAACCTTATGCAAGAGAA
CTTGCTAAACGTTTTAAAAATGCAGGTTTTCATGTTGACGTGGATAGCACCCAAGAATCTGTCAGCAAAAAAGTTCGTAA
TGCGCAACTGGCTCAATTTAACTATATTTTAACGATCGGGGACCAAGAAGTTGAACACAAAACGGCTAATTTAAGAACTC
GGGATAATGTCGTCCATGGTGAAATTCAAATTGATGAATTTATACAAAAGTTAGAAATTGAAAAACAACAACGTCAATCC
CATTCTCCTTACGCTTCAGCAGAAAGGAATTAA

Upstream 100 bases:

>100_bases
TTCATGTAAACTCCTTTTTATACGAAATACCGAAATAAACTTGTAAATAAGAAGTCATCAGAAAGTTAAAAATTGATTTC
TGAAATTTGGTAAAATCAAA

Downstream 100 bases:

>100_bases
AAAATGAAGACAATTGCGATTAGCAGTTTTAAAGGAGGAACGGCCAAAACATCGACAGCTTTACACATAGGGGCTGCTTT
GGCAAAGTTTCATAAGAAAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MIRNNKSMFIKLKDQSSYEMPSGSTAKDLADKLNLKGPHEALGASINGKTVDLSYPLQEGDQVILWGFNDPEGKEIFWHT
SAHVLAQAILRLWPDAQPTIGPPIENGFYYDFANLTISDADFEKIEKEMQAIISENFQIKREVISTKSDALKQFQNNPYK
CELINSFEDESTLTGYRQGEFYDLCRGPHLFNLGKIKALKLMKTAGAYWRGDSNKEMLTRIYAISFPDRKLLKDYLHQLE
EAKKRDHKLLGAKLDLFSLKEEAPGMPFIHPKGLIVWNQLVAYIRECLSRHDYIEIKTPTMMTKELWEISGHWGNYRQNM
FISQIEDRDFAIKPMNCPGCMLYYKSHTHSYRELPLRIAEIGNVHRYEPSGSLSGLFRVRSFHQDDAHIFMKPSDIQQEI
LGVLALADEIYSTFGLSYRLELSTRPEKNTIGTDHEWEVATAGLKGALDEMGKEYRINEGDGAFYGPKIDFHIRDAINRS
WQCGTIQLDMALPEKFELEYTFSDGTRQRPVMIHRAIFGSIERFFGILIEHYVGKFPLWLSPSQIRFITVADRHEPYARE
LAKRFKNAGFHVDVDSTQESVSKKVRNAQLAQFNYILTIGDQEVEHKTANLRTRDNVVHGEIQIDEFIQKLEIEKQQRQS
HSPYASAERN

Sequences:

>Translated_650_residues
MIRNNKSMFIKLKDQSSYEMPSGSTAKDLADKLNLKGPHEALGASINGKTVDLSYPLQEGDQVILWGFNDPEGKEIFWHT
SAHVLAQAILRLWPDAQPTIGPPIENGFYYDFANLTISDADFEKIEKEMQAIISENFQIKREVISTKSDALKQFQNNPYK
CELINSFEDESTLTGYRQGEFYDLCRGPHLFNLGKIKALKLMKTAGAYWRGDSNKEMLTRIYAISFPDRKLLKDYLHQLE
EAKKRDHKLLGAKLDLFSLKEEAPGMPFIHPKGLIVWNQLVAYIRECLSRHDYIEIKTPTMMTKELWEISGHWGNYRQNM
FISQIEDRDFAIKPMNCPGCMLYYKSHTHSYRELPLRIAEIGNVHRYEPSGSLSGLFRVRSFHQDDAHIFMKPSDIQQEI
LGVLALADEIYSTFGLSYRLELSTRPEKNTIGTDHEWEVATAGLKGALDEMGKEYRINEGDGAFYGPKIDFHIRDAINRS
WQCGTIQLDMALPEKFELEYTFSDGTRQRPVMIHRAIFGSIERFFGILIEHYVGKFPLWLSPSQIRFITVADRHEPYARE
LAKRFKNAGFHVDVDSTQESVSKKVRNAQLAQFNYILTIGDQEVEHKTANLRTRDNVVHGEIQIDEFIQKLEIEKQQRQS
HSPYASAERN
>Mature_650_residues
MIRNNKSMFIKLKDQSSYEMPSGSTAKDLADKLNLKGPHEALGASINGKTVDLSYPLQEGDQVILWGFNDPEGKEIFWHT
SAHVLAQAILRLWPDAQPTIGPPIENGFYYDFANLTISDADFEKIEKEMQAIISENFQIKREVISTKSDALKQFQNNPYK
CELINSFEDESTLTGYRQGEFYDLCRGPHLFNLGKIKALKLMKTAGAYWRGDSNKEMLTRIYAISFPDRKLLKDYLHQLE
EAKKRDHKLLGAKLDLFSLKEEAPGMPFIHPKGLIVWNQLVAYIRECLSRHDYIEIKTPTMMTKELWEISGHWGNYRQNM
FISQIEDRDFAIKPMNCPGCMLYYKSHTHSYRELPLRIAEIGNVHRYEPSGSLSGLFRVRSFHQDDAHIFMKPSDIQQEI
LGVLALADEIYSTFGLSYRLELSTRPEKNTIGTDHEWEVATAGLKGALDEMGKEYRINEGDGAFYGPKIDFHIRDAINRS
WQCGTIQLDMALPEKFELEYTFSDGTRQRPVMIHRAIFGSIERFFGILIEHYVGKFPLWLSPSQIRFITVADRHEPYARE
LAKRFKNAGFHVDVDSTQESVSKKVRNAQLAQFNYILTIGDQEVEHKTANLRTRDNVVHGEIQIDEFIQKLEIEKQQRQS
HSPYASAERN

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=619, Percent_Identity=43.7802907915994, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI38202255, Length=603, Percent_Identity=44.7761194029851, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI20070344, Length=630, Percent_Identity=40.3174603174603, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=42.4528301886792, Blast_Score=524, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=612, Percent_Identity=44.281045751634, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71984184, Length=612, Percent_Identity=44.281045751634, Blast_Score=535, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322112, Length=669, Percent_Identity=41.1061285500747, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322654, Length=399, Percent_Identity=38.3458646616541, Blast_Score=286, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24583842, Length=622, Percent_Identity=42.604501607717, Blast_Score=530, Evalue=1e-150,
Organism=Drosophila melanogaster, GI28574141, Length=622, Percent_Identity=42.604501607717, Blast_Score=530, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24583839, Length=622, Percent_Identity=42.604501607717, Blast_Score=530, Evalue=1e-150,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PARUW (Q6M9L0)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_009014.1
- ProteinModelPortal:   Q6M9L0
- SMR:   Q6M9L0
- STRING:   Q6M9L0
- GeneID:   2779714
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc2015
- NMPDR:   fig|264201.1.peg.2015
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q6M9L0
- ProtClustDB:   PRK00413
- BioCyc:   CPRO264201:PC2015-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74958; Mature: 74958

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNNKSMFIKLKDQSSYEMPSGSTAKDLADKLNLKGPHEALGASINGKTVDLSYPLQEG
CCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCC
DQVILWGFNDPEGKEIFWHTSAHVLAQAILRLWPDAQPTIGPPIENGFYYDFANLTISDA
CEEEEECCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEEECCC
DFEKIEKEMQAIISENFQIKREVISTKSDALKQFQNNPYKCELINSFEDESTLTGYRQGE
HHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
FYDLCRGPHLFNLGKIKALKLMKTAGAYWRGDSNKEMLTRIYAISFPDRKLLKDYLHQLE
HHHHHCCCCEECCCCHHHHHHHHHCCCEECCCCCHHHHHHEEEECCCCHHHHHHHHHHHH
EAKKRDHKLLGAKLDLFSLKEEAPGMPFIHPKGLIVWNQLVAYIRECLSRHDYIEIKTPT
HHHHHHHHHHCCEEHEEEHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCH
MMTKELWEISGHWGNYRQNMFISQIEDRDFAIKPMNCPGCMLYYKSHTHSYRELPLRIAE
HHHHHHHHHCCCCCCHHHCHHHHHHCCCCEEEECCCCCCEEEEEECCCCCHHHCCEEEEC
IGNVHRYEPSGSLSGLFRVRSFHQDDAHIFMKPSDIQQEILGVLALADEIYSTFGLSYRL
CCCCEEECCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEE
ELSTRPEKNTIGTDHEWEVATAGLKGALDEMGKEYRINEGDGAFYGPKIDFHIRDAINRS
EECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHHCCC
WQCGTIQLDMALPEKFELEYTFSDGTRQRPVMIHRAIFGSIERFFGILIEHYVGKFPLWL
CCCCEEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SPSQIRFITVADRHEPYARELAKRFKNAGFHVDVDSTQESVSKKVRNAQLAQFNYILTIG
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCEEEEEEEEEEC
DQEVEHKTANLRTRDNVVHGEIQIDEFIQKLEIEKQQRQSHSPYASAERN
CCHHHHHHCCCEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIRNNKSMFIKLKDQSSYEMPSGSTAKDLADKLNLKGPHEALGASINGKTVDLSYPLQEG
CCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCC
DQVILWGFNDPEGKEIFWHTSAHVLAQAILRLWPDAQPTIGPPIENGFYYDFANLTISDA
CEEEEECCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEEECCC
DFEKIEKEMQAIISENFQIKREVISTKSDALKQFQNNPYKCELINSFEDESTLTGYRQGE
HHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
FYDLCRGPHLFNLGKIKALKLMKTAGAYWRGDSNKEMLTRIYAISFPDRKLLKDYLHQLE
HHHHHCCCCEECCCCHHHHHHHHHCCCEECCCCCHHHHHHEEEECCCCHHHHHHHHHHHH
EAKKRDHKLLGAKLDLFSLKEEAPGMPFIHPKGLIVWNQLVAYIRECLSRHDYIEIKTPT
HHHHHHHHHHCCEEHEEEHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCH
MMTKELWEISGHWGNYRQNMFISQIEDRDFAIKPMNCPGCMLYYKSHTHSYRELPLRIAE
HHHHHHHHHCCCCCCHHHCHHHHHHCCCCEEEECCCCCCEEEEEECCCCCHHHCCEEEEC
IGNVHRYEPSGSLSGLFRVRSFHQDDAHIFMKPSDIQQEILGVLALADEIYSTFGLSYRL
CCCCEEECCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEE
ELSTRPEKNTIGTDHEWEVATAGLKGALDEMGKEYRINEGDGAFYGPKIDFHIRDAINRS
EECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEEHHHHCCC
WQCGTIQLDMALPEKFELEYTFSDGTRQRPVMIHRAIFGSIERFFGILIEHYVGKFPLWL
CCCCEEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SPSQIRFITVADRHEPYARELAKRFKNAGFHVDVDSTQESVSKKVRNAQLAQFNYILTIG
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCEEEEEEEEEEC
DQEVEHKTANLRTRDNVVHGEIQIDEFIQKLEIEKQQRQSHSPYASAERN
CCHHHHHHCCCEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA