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The map label for this gene is ung [H]

Identifier: 46447646

GI number: 46447646

Start: 2390751

End: 2391461

Strand: Reverse

Name: ung [H]

Synonym: pc2012

Alternate gene names: 46447646

Gene position: 2391461-2390751 (Counterclockwise)

Preceding gene: 46447647

Following gene: 46447645

Centisome position: 99.05

GC content: 36.85

Gene sequence:

>711_bases
ATGTTAGATAAGAACTACACTCCTTTTATTTTAGAACCAAGTTGGCAAAAAGTTCTCAAACAAGAGCTTGAGCAACCTTA
TATTTTTAATTTAGCAACCTTTATTGAAAATGAATACACCTCCTCTCCAAGCCCAATTTATCCTCCGCATGATTTAATTT
TTAATGCATTTTATAATACTCCTTATGAAAAAGTACAGGTAGTTATTATGGGTCAAGATCCTTATCATGGCCCAGGGCAA
GCCCATGGACTTAGCTTTAGTGTCCCTAAGGGAATAAGGCCACCCCCTTCTTTGCAAAATATTTTTAAAGAATTACAAAC
TGACATTCTCTTACCAATTCCTTCCCATGGTTGTTTGTTAAAGTGGGCTAAACAAGGCGTTTTACTTCTCAATGCCACTT
TAACCGTTAAAAAAAGTGAGCCCTTGTCTCATCATGGCAGAGGATGGGAGCGATTTACTGATGCAGCTATTCTTCAACTT
ATCGAACGCCAAGATCCTATTATTTTTGTTCTATGGGGAAAATCCGCTCAAGATAAATGTCGTTTTTTAAAAGAATCTGT
CAATATTAAGCGTCATTATATTCTCACTGCTGCACATCCTTCTCCCTATTCAGCTGCCAATGGTTTTTTCGGTTGTCGTC
ATTTTTCTAAAATTAATGCTTTACTCGAACAGCAAGGCAAATGCCCTATTGATTGGAGTCTTGATAATTAG

Upstream 100 bases:

>100_bases
TTTATAATCAAATTAAGAAGAATTCTCCTAACTTTACTTCTGCTCAAAAGAAACAAATTCATCACTTACTTGAGCAGATG
CAAAATCTTATAGGTTATTA

Downstream 100 bases:

>100_bases
AATGAAAAATAAATACCTATACTTCCATTCGACAAAATTAAAAAAAGAAAAAATAAGCTTGCCTTGAAACTCTTGAGTAC
CTAAAAAGAAAAAAAGTGTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MLDKNYTPFILEPSWQKVLKQELEQPYIFNLATFIENEYTSSPSPIYPPHDLIFNAFYNTPYEKVQVVIMGQDPYHGPGQ
AHGLSFSVPKGIRPPPSLQNIFKELQTDILLPIPSHGCLLKWAKQGVLLLNATLTVKKSEPLSHHGRGWERFTDAAILQL
IERQDPIIFVLWGKSAQDKCRFLKESVNIKRHYILTAAHPSPYSAANGFFGCRHFSKINALLEQQGKCPIDWSLDN

Sequences:

>Translated_236_residues
MLDKNYTPFILEPSWQKVLKQELEQPYIFNLATFIENEYTSSPSPIYPPHDLIFNAFYNTPYEKVQVVIMGQDPYHGPGQ
AHGLSFSVPKGIRPPPSLQNIFKELQTDILLPIPSHGCLLKWAKQGVLLLNATLTVKKSEPLSHHGRGWERFTDAAILQL
IERQDPIIFVLWGKSAQDKCRFLKESVNIKRHYILTAAHPSPYSAANGFFGCRHFSKINALLEQQGKCPIDWSLDN
>Mature_236_residues
MLDKNYTPFILEPSWQKVLKQELEQPYIFNLATFIENEYTSSPSPIYPPHDLIFNAFYNTPYEKVQVVIMGQDPYHGPGQ
AHGLSFSVPKGIRPPPSLQNIFKELQTDILLPIPSHGCLLKWAKQGVLLLNATLTVKKSEPLSHHGRGWERFTDAAILQL
IERQDPIIFVLWGKSAQDKCRFLKESVNIKRHYILTAAHPSPYSAANGFFGCRHFSKINALLEQQGKCPIDWSLDN

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=230, Percent_Identity=50, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI6224979, Length=230, Percent_Identity=50, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1788934, Length=222, Percent_Identity=49.5495495495495, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17556304, Length=223, Percent_Identity=46.6367713004484, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=38.8185654008439, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26898; Mature: 26898

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKNYTPFILEPSWQKVLKQELEQPYIFNLATFIENEYTSSPSPIYPPHDLIFNAFYNT
CCCCCCCCEEECCCHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
PYEKVQVVIMGQDPYHGPGQAHGLSFSVPKGIRPPPSLQNIFKELQTDILLPIPSHGCLL
CCHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHH
KWAKQGVLLLNATLTVKKSEPLSHHGRGWERFTDAAILQLIERQDPIIFVLWGKSAQDKC
HHHCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
RFLKESVNIKRHYILTAAHPSPYSAANGFFGCRHFSKINALLEQQGKCPIDWSLDN
HHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLDKNYTPFILEPSWQKVLKQELEQPYIFNLATFIENEYTSSPSPIYPPHDLIFNAFYNT
CCCCCCCCEEECCCHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
PYEKVQVVIMGQDPYHGPGQAHGLSFSVPKGIRPPPSLQNIFKELQTDILLPIPSHGCLL
CCHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHH
KWAKQGVLLLNATLTVKKSEPLSHHGRGWERFTDAAILQLIERQDPIIFVLWGKSAQDKC
HHHCCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
RFLKESVNIKRHYILTAAHPSPYSAANGFFGCRHFSKINALLEQQGKCPIDWSLDN
HHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA