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The map label for this gene is icd [H]

Identifier: 46447417

GI number: 46447417

Start: 2137886

End: 2139337

Strand: Direct

Name: icd [H]

Synonym: pc1783

Alternate gene names: 46447417

Gene position: 2137886-2139337 (Clockwise)

Preceding gene: 46447415

Following gene: 46447422

Centisome position: 88.54

GC content: 37.33

Gene sequence:

>1452_bases
GTGATGGCAGCACAACTGATACCGATTACTGTGGCCGAGGGAGATGGAATTGGGCCGGAAATTATGGATGCTACGCTAAG
AATTTTAAAAGCAGCTGGAGCTCCTTTAGATATAAAAAATGTTGAAATTGGAGAAAAGGTTTATTTAAGTGGACAACCAA
CAGGAATTGAAAATTCCACTTGGGATTTAATTAGACAATCCAAAGCTCTTTTAAAAGCCCCAATTACCACTCCCCAAGGT
GGTGGCTTTAAAAGTCTAAACGTGACCATTCGCACCACTCTAGGATTATATGCTAATGTGCGCCCTTGTGTAGCTTATTA
CCCATTCGTTGAAACCAAATATCCAGGCATGAACGTTGTGATTGTCAGAGAAAACGAAGAAGACCTTTATACTGGAATTG
AATATCGACAAACTCCCGACGTCTACGAAGCACTTAAACTCATTACAAGACCCGGATGTGAGAAAATCATTCGTTATGCT
TTCGAATATGCGCAAATCTATCACCGCAAAAAAGTCACTTGTTTTACAAAAGATAATATTTTGAAGTTAACTGATGGGCT
TTTCCATAAAATTTTTGATGAAATTGGAGCCGAATATCCACAAATTGAAAAAGAGCATTGGATTGTTGATATCGGAGCAG
CTAAACTAGCTGATACACCAACAGCTTTTGATGTAATTGTTATGCCTAATTTGTATGGAGACATTTTATCAGATGTTGCT
GCTCAAATTGCTGGATCTGTCGGTCTAGCCGGATCTGCAAATATTGGTAATTCGGGAGCCATGTTTGAAGCTATTCATGG
ATCTGCGCCTAGACGGGCTGGACAAAATCTAGCCAATCCTTCAGGTCTTTTACTGGCTGCCATTCAAATGCTTGTTCATT
TAGAACAATCGAATTTAGCTGAACTCATTCATAATGCCTGGCTAAAAACGCTTGAAGAAGGGATTCATACTTATGATATT
TTTAAAGAAAAAACAAGTAAGCAGAAAGTTGGAACAAAGGAATTTGCGAATGCCGTAACTGCCCGTTTAGGAAAAAAACC
CGAAACATTACCCGCAGCTCACTATAGCACATCTTTTCATATCAAACATTCCAACTTTTCATCTCTTAAAAATTTCAAAC
AAGAATTATATGGGATAGACATTTTTATTAAATGGAGCGAAGATGTAGAAACATTAGCGACTCTTCTTCAATCCACGTCT
AATCACGATTTAAAATTAAAAATGATCAATAACCGAGGTGTAAAAGTATGGCCAAATAAAATGCCTGAAACAGCTTGCAT
AGACAACTGGCGTTGTAGATTCATATCTTCTACAAATAAAATCGTATCCCAAGAGCAAATTCTCAATTTACTAAACAGAC
TTGTACAAAAAAAACTTACGCTGACACAAACTGCTTATTTATTTGCTTTTGATGGACAGGCGGGTTATACTTTAGCTCAA
GATGAACAATAA

Upstream 100 bases:

>100_bases
CTTTCAGCATAGTTACTTTCAGTAAGGTTTTGATTGGATTTTAAACAACGAACGGATTAGTCTCAAGTTTGATTATTTAA
AAATAAATTTATGGGAATTT

Downstream 100 bases:

>100_bases
AAAGCTAATATTTAAGTCTGAGATGAGAATGAAATTTCGTTAATCAAAAAGTTTCAAGCGATAAATTCTTCATATTCTCT
TTAATATGTTTTTTACCCCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MMAAQLIPITVAEGDGIGPEIMDATLRILKAAGAPLDIKNVEIGEKVYLSGQPTGIENSTWDLIRQSKALLKAPITTPQG
GGFKSLNVTIRTTLGLYANVRPCVAYYPFVETKYPGMNVVIVRENEEDLYTGIEYRQTPDVYEALKLITRPGCEKIIRYA
FEYAQIYHRKKVTCFTKDNILKLTDGLFHKIFDEIGAEYPQIEKEHWIVDIGAAKLADTPTAFDVIVMPNLYGDILSDVA
AQIAGSVGLAGSANIGNSGAMFEAIHGSAPRRAGQNLANPSGLLLAAIQMLVHLEQSNLAELIHNAWLKTLEEGIHTYDI
FKEKTSKQKVGTKEFANAVTARLGKKPETLPAAHYSTSFHIKHSNFSSLKNFKQELYGIDIFIKWSEDVETLATLLQSTS
NHDLKLKMINNRGVKVWPNKMPETACIDNWRCRFISSTNKIVSQEQILNLLNRLVQKKLTLTQTAYLFAFDGQAGYTLAQ
DEQ

Sequences:

>Translated_483_residues
MMAAQLIPITVAEGDGIGPEIMDATLRILKAAGAPLDIKNVEIGEKVYLSGQPTGIENSTWDLIRQSKALLKAPITTPQG
GGFKSLNVTIRTTLGLYANVRPCVAYYPFVETKYPGMNVVIVRENEEDLYTGIEYRQTPDVYEALKLITRPGCEKIIRYA
FEYAQIYHRKKVTCFTKDNILKLTDGLFHKIFDEIGAEYPQIEKEHWIVDIGAAKLADTPTAFDVIVMPNLYGDILSDVA
AQIAGSVGLAGSANIGNSGAMFEAIHGSAPRRAGQNLANPSGLLLAAIQMLVHLEQSNLAELIHNAWLKTLEEGIHTYDI
FKEKTSKQKVGTKEFANAVTARLGKKPETLPAAHYSTSFHIKHSNFSSLKNFKQELYGIDIFIKWSEDVETLATLLQSTS
NHDLKLKMINNRGVKVWPNKMPETACIDNWRCRFISSTNKIVSQEQILNLLNRLVQKKLTLTQTAYLFAFDGQAGYTLAQ
DEQ
>Mature_483_residues
MMAAQLIPITVAEGDGIGPEIMDATLRILKAAGAPLDIKNVEIGEKVYLSGQPTGIENSTWDLIRQSKALLKAPITTPQG
GGFKSLNVTIRTTLGLYANVRPCVAYYPFVETKYPGMNVVIVRENEEDLYTGIEYRQTPDVYEALKLITRPGCEKIIRYA
FEYAQIYHRKKVTCFTKDNILKLTDGLFHKIFDEIGAEYPQIEKEHWIVDIGAAKLADTPTAFDVIVMPNLYGDILSDVA
AQIAGSVGLAGSANIGNSGAMFEAIHGSAPRRAGQNLANPSGLLLAAIQMLVHLEQSNLAELIHNAWLKTLEEGIHTYDI
FKEKTSKQKVGTKEFANAVTARLGKKPETLPAAHYSTSFHIKHSNFSSLKNFKQELYGIDIFIKWSEDVETLATLLQSTS
NHDLKLKMINNRGVKVWPNKMPETACIDNWRCRFISSTNKIVSQEQILNLLNRLVQKKLTLTQTAYLFAFDGQAGYTLAQ
DEQ

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=307, Percent_Identity=39.7394136807818, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI4758582, Length=326, Percent_Identity=38.9570552147239, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI28178838, Length=307, Percent_Identity=39.413680781759, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI28178821, Length=304, Percent_Identity=34.5394736842105, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI28178816, Length=304, Percent_Identity=34.5394736842105, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI28178819, Length=168, Percent_Identity=40.4761904761905, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=33.4190231362468, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1788101, Length=345, Percent_Identity=31.304347826087, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87081683, Length=361, Percent_Identity=31.3019390581717, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71986051, Length=311, Percent_Identity=40.1929260450161, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25144293, Length=326, Percent_Identity=40.1840490797546, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=38.0191693290735, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=33.5260115606936, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324709, Length=340, Percent_Identity=41.7647058823529, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324291, Length=342, Percent_Identity=36.2573099415205, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322097, Length=351, Percent_Identity=33.9031339031339, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319830, Length=366, Percent_Identity=28.1420765027322, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643268, Length=336, Percent_Identity=39.8809523809524, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24643270, Length=336, Percent_Identity=39.8809523809524, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24661184, Length=319, Percent_Identity=39.4984326018809, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI161078635, Length=329, Percent_Identity=34.6504559270517, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078633, Length=329, Percent_Identity=34.6504559270517, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24650122, Length=329, Percent_Identity=34.6504559270517, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078637, Length=329, Percent_Identity=34.6504559270517, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078639, Length=324, Percent_Identity=34.8765432098765, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI281362242, Length=337, Percent_Identity=34.7181008902077, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24648872, Length=337, Percent_Identity=34.7181008902077, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20130355, Length=342, Percent_Identity=26.9005847953216, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45550436, Length=224, Percent_Identity=24.1071428571429, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53670; Mature: 53670

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAAQLIPITVAEGDGIGPEIMDATLRILKAAGAPLDIKNVEIGEKVYLSGQPTGIENST
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCCCCCCCH
WDLIRQSKALLKAPITTPQGGGFKSLNVTIRTTLGLYANVRPCVAYYPFVETKYPGMNVV
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECHHCCCCHHHEECCCCCCCCCCCEEE
IVRENEEDLYTGIEYRQTPDVYEALKLITRPGCEKIIRYAFEYAQIYHRKKVTCFTKDNI
EEECCCCHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCC
LKLTDGLFHKIFDEIGAEYPQIEKEHWIVDIGAAKLADTPTAFDVIVMPNLYGDILSDVA
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCEEEEECCHHHHHHHHHHH
AQIAGSVGLAGSANIGNSGAMFEAIHGSAPRRAGQNLANPSGLLLAAIQMLVHLEQSNLA
HHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCHHHHH
ELIHNAWLKTLEEGIHTYDIFKEKTSKQKVGTKEFANAVTARLGKKPETLPAAHYSTSFH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IKHSNFSSLKNFKQELYGIDIFIKWSEDVETLATLLQSTSNHDLKLKMINNRGVKVWPNK
EECCCHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEECCCC
MPETACIDNWRCRFISSTNKIVSQEQILNLLNRLVQKKLTLTQTAYLFAFDGQAGYTLAQ
CCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEECC
DEQ
CCC
>Mature Secondary Structure
MMAAQLIPITVAEGDGIGPEIMDATLRILKAAGAPLDIKNVEIGEKVYLSGQPTGIENST
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCCCCCCCH
WDLIRQSKALLKAPITTPQGGGFKSLNVTIRTTLGLYANVRPCVAYYPFVETKYPGMNVV
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECHHCCCCHHHEECCCCCCCCCCCEEE
IVRENEEDLYTGIEYRQTPDVYEALKLITRPGCEKIIRYAFEYAQIYHRKKVTCFTKDNI
EEECCCCHHHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEECCCC
LKLTDGLFHKIFDEIGAEYPQIEKEHWIVDIGAAKLADTPTAFDVIVMPNLYGDILSDVA
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCCCCEEEEECCHHHHHHHHHHH
AQIAGSVGLAGSANIGNSGAMFEAIHGSAPRRAGQNLANPSGLLLAAIQMLVHLEQSNLA
HHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCHHHHH
ELIHNAWLKTLEEGIHTYDIFKEKTSKQKVGTKEFANAVTARLGKKPETLPAAHYSTSFH
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
IKHSNFSSLKNFKQELYGIDIFIKWSEDVETLATLLQSTSNHDLKLKMINNRGVKVWPNK
EECCCHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCEEECCCC
MPETACIDNWRCRFISSTNKIVSQEQILNLLNRLVQKKLTLTQTAYLFAFDGQAGYTLAQ
CCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCEECC
DEQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA