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The map label for this gene is htpG [H]

Identifier: 46447169

GI number: 46447169

Start: 1837801

End: 1839648

Strand: Direct

Name: htpG [H]

Synonym: pc1535

Alternate gene names: 46447169

Gene position: 1837801-1839648 (Clockwise)

Preceding gene: 46447168

Following gene: 46447170

Centisome position: 76.12

GC content: 32.41

Gene sequence:

>1848_bases
ATGGAAAAAGGTTCTCTTCAAATACACAGTGAAAATATTTTACCAATCATCAAAAAATGGCTATATTCTGATAAAGACAT
TTTTATGAGAGAATTGGTTTCTAACTCCTGCGATGCGATTCAAAAAGTTAAAATATTACGCGATCAAGGAGACGTAGAAG
TTAAAGATGAAGATTTTCGTATTGATATTCAAATAGATAAAGAAACTCGTATCCTAAAATTTATCGATAATGGAATTGGA
ATGGATGCGGAAGAAGTAAAAAAATATATTGCGCAAATAGCTTTTTCGGGTGCTGAGGAATTTTTAAATAAATATCAATC
AAATCAAGAAAGCGAACAAATTATCGGTCATTTTGGTTTAGGTTTTTATTCTGCTTACATGGTCGCTGATAAGGTAGAAA
TCAACACACTTTCTTATAAAAATGAGGCTGAACCTGTTCTATGGATTTGTGACGGATCATCTGATTATGAAATGGATCGT
GGGACTAAAAGTAGCAGAGGAACAGAAATTACTCTCTTTATTAGTAAAGATAGCGATGAATATTTAGATAAAGAACACTT
AAAAAAAATCTTAATACACTATTGTTCGTTTCTCCCTTATCCCATTTATTTAGATGGTCAGCGAATCAATGAGTTTGAAC
CCTTATGGATTAAATCTGCTTCTGATTGTACAAAAGAAGATTATTTAAATTTTTATCACCAATTATTTCCTCTAGAAGAA
GATCCTCTTTTTTGGGTTCATCTTAACGTCGATTATCCATTTCGTTTAAAAGGAATTCTTTATTTTCCTAAAATCAAACG
TGATTTTGATATGAATAAAAGTCATGTTAGCCTTTACTGCAATCGAGTTTTCGTTTCAGATAACTGCAAAGATTTAATTC
CCAACTACTTAAGTGTTTTAAAAGGAATTATTGATAGTCCAGACATTCCATTGAATGTCTCCAGAAGCTATTTACAAATG
GATCGCACTGTTCGACAACTTGCAAGTCATATTTCTAAAAAGGTTTCGGATAGCTTGTCTACCCTTTATAAAACTGACAG
GGAAAGGTTTATTCAAGCTTGGCAGGATAGTTCTGTTATCGTCAAATTAGGAATTTTAGAAGATGATAAATTTTATGAAA
GAGCTAAAGAGTTTTTAATTTGGAAAAATACTGATCAAGAATGGTTGACTATCCCTGATTATCTAGAAAGAAATAAAGAG
AAAACGAAAGATAAAGTTTTTTATGCTACTGATGAGAAAATTGGCGCTCACATGATGGATATTTATAAACAACAAGGTAT
TGAAATACTATCAGCGAATAGTCCTTTAGATCCTTACCTAATCAATTTTCTAGAAAATAAATTAGCCCCTATCACATTCC
AGCGTATTGATGCTGAAGTACATGAAAATCTAGTGGATAAAAGCCGAGAAAAAACAGTTCTTGATGCTGAAGGGAGAACT
GAAGCAACCAAGCTTGCTGAATTTGTGCAAACTAAACTGAATGATGATAATGTTGAAGTCCAAGCGAAAAGTTTGGCCTC
TGATTCACTTCCAGGTTTTATTGTTATTGATGAGAAACAACGGAGAATGCGTGAGTACATGATGCGCTTAGATCCAGAAG
AACGTAATATCCAAATGTCTTTGTTTAATAAAAAAACTTTTGTGATTAACACAAACAACTCTCTTTTTGAATCGATTCAA
AAGCTAGACCAACAAAATCCAAATTTGGCAAAAGATTTGACCCAAGAAGTTTATGAGCTTGCCCTTCTTTCACAAAGAGA
AATGGAACCTCATTCTTTACATGAATTTGTTAACCGAAGTAATCGTGTCTTAGAAGCTTTAACAAAAGAAGCTCTTAAAA
ACACATAA

Upstream 100 bases:

>100_bases
ACAAACTGTTCAAGTGGCAAAACTTCCTCTAGACGCATTAGTAGAAATCTCTTGCATTGCTATAATTTCTTAATATTAAT
GAATTTTTAAAGGTATTCAA

Downstream 100 bases:

>100_bases
ATCTCTTCGCTTGAACTCAAAGAGGCAATATGCTACATATGGCCTCTTTTTACTTCTTCAAAGCGTTAAAATTATGTCAA
CCACGTATACGTCCAACTCT

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MEKGSLQIHSENILPIIKKWLYSDKDIFMRELVSNSCDAIQKVKILRDQGDVEVKDEDFRIDIQIDKETRILKFIDNGIG
MDAEEVKKYIAQIAFSGAEEFLNKYQSNQESEQIIGHFGLGFYSAYMVADKVEINTLSYKNEAEPVLWICDGSSDYEMDR
GTKSSRGTEITLFISKDSDEYLDKEHLKKILIHYCSFLPYPIYLDGQRINEFEPLWIKSASDCTKEDYLNFYHQLFPLEE
DPLFWVHLNVDYPFRLKGILYFPKIKRDFDMNKSHVSLYCNRVFVSDNCKDLIPNYLSVLKGIIDSPDIPLNVSRSYLQM
DRTVRQLASHISKKVSDSLSTLYKTDRERFIQAWQDSSVIVKLGILEDDKFYERAKEFLIWKNTDQEWLTIPDYLERNKE
KTKDKVFYATDEKIGAHMMDIYKQQGIEILSANSPLDPYLINFLENKLAPITFQRIDAEVHENLVDKSREKTVLDAEGRT
EATKLAEFVQTKLNDDNVEVQAKSLASDSLPGFIVIDEKQRRMREYMMRLDPEERNIQMSLFNKKTFVINTNNSLFESIQ
KLDQQNPNLAKDLTQEVYELALLSQREMEPHSLHEFVNRSNRVLEALTKEALKNT

Sequences:

>Translated_615_residues
MEKGSLQIHSENILPIIKKWLYSDKDIFMRELVSNSCDAIQKVKILRDQGDVEVKDEDFRIDIQIDKETRILKFIDNGIG
MDAEEVKKYIAQIAFSGAEEFLNKYQSNQESEQIIGHFGLGFYSAYMVADKVEINTLSYKNEAEPVLWICDGSSDYEMDR
GTKSSRGTEITLFISKDSDEYLDKEHLKKILIHYCSFLPYPIYLDGQRINEFEPLWIKSASDCTKEDYLNFYHQLFPLEE
DPLFWVHLNVDYPFRLKGILYFPKIKRDFDMNKSHVSLYCNRVFVSDNCKDLIPNYLSVLKGIIDSPDIPLNVSRSYLQM
DRTVRQLASHISKKVSDSLSTLYKTDRERFIQAWQDSSVIVKLGILEDDKFYERAKEFLIWKNTDQEWLTIPDYLERNKE
KTKDKVFYATDEKIGAHMMDIYKQQGIEILSANSPLDPYLINFLENKLAPITFQRIDAEVHENLVDKSREKTVLDAEGRT
EATKLAEFVQTKLNDDNVEVQAKSLASDSLPGFIVIDEKQRRMREYMMRLDPEERNIQMSLFNKKTFVINTNNSLFESIQ
KLDQQNPNLAKDLTQEVYELALLSQREMEPHSLHEFVNRSNRVLEALTKEALKNT
>Mature_615_residues
MEKGSLQIHSENILPIIKKWLYSDKDIFMRELVSNSCDAIQKVKILRDQGDVEVKDEDFRIDIQIDKETRILKFIDNGIG
MDAEEVKKYIAQIAFSGAEEFLNKYQSNQESEQIIGHFGLGFYSAYMVADKVEINTLSYKNEAEPVLWICDGSSDYEMDR
GTKSSRGTEITLFISKDSDEYLDKEHLKKILIHYCSFLPYPIYLDGQRINEFEPLWIKSASDCTKEDYLNFYHQLFPLEE
DPLFWVHLNVDYPFRLKGILYFPKIKRDFDMNKSHVSLYCNRVFVSDNCKDLIPNYLSVLKGIIDSPDIPLNVSRSYLQM
DRTVRQLASHISKKVSDSLSTLYKTDRERFIQAWQDSSVIVKLGILEDDKFYERAKEFLIWKNTDQEWLTIPDYLERNKE
KTKDKVFYATDEKIGAHMMDIYKQQGIEILSANSPLDPYLINFLENKLAPITFQRIDAEVHENLVDKSREKTVLDAEGRT
EATKLAEFVQTKLNDDNVEVQAKSLASDSLPGFIVIDEKQRRMREYMMRLDPEERNIQMSLFNKKTFVINTNNSLFESIQ
KLDQQNPNLAKDLTQEVYELALLSQREMEPHSLHEFVNRSNRVLEALTKEALKNT

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI155722983, Length=606, Percent_Identity=26.5676567656766, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI4507677, Length=514, Percent_Identity=28.4046692607004, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI154146191, Length=253, Percent_Identity=30.0395256916996, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI153792590, Length=254, Percent_Identity=29.9212598425197, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI20149594, Length=253, Percent_Identity=30.4347826086957, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1786679, Length=470, Percent_Identity=33.6170212765957, Blast_Score=258, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI115535205, Length=639, Percent_Identity=27.2300469483568, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI115535167, Length=413, Percent_Identity=30.7506053268765, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17542208, Length=504, Percent_Identity=28.7698412698413, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17559162, Length=517, Percent_Identity=26.6924564796905, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6325016, Length=425, Percent_Identity=29.8823529411765, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323840, Length=426, Percent_Identity=29.3427230046948, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24586016, Length=613, Percent_Identity=28.5481239804241, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21357739, Length=515, Percent_Identity=28.3495145631068, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17647529, Length=405, Percent_Identity=26.4197530864197, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 71904; Mature: 71904

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKGSLQIHSENILPIIKKWLYSDKDIFMRELVSNSCDAIQKVKILRDQGDVEVKDEDFR
CCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCEE
IDIQIDKETRILKFIDNGIGMDAEEVKKYIAQIAFSGAEEFLNKYQSNQESEQIIGHFGL
EEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH
GFYSAYMVADKVEINTLSYKNEAEPVLWICDGSSDYEMDRGTKSSRGTEITLFISKDSDE
HHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHH
YLDKEHLKKILIHYCSFLPYPIYLDGQRINEFEPLWIKSASDCTKEDYLNFYHQLFPLEE
HCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCC
DPLFWVHLNVDYPFRLKGILYFPKIKRDFDMNKSHVSLYCNRVFVSDNCKDLIPNYLSVL
CCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHH
KGIIDSPDIPLNVSRSYLQMDRTVRQLASHISKKVSDSLSTLYKTDRERFIQAWQDSSVI
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VKLGILEDDKFYERAKEFLIWKNTDQEWLTIPDYLERNKEKTKDKVFYATDEKIGAHMMD
EEEEECCCHHHHHHHHHEEEECCCCCCCEECCHHHHCCHHHCCCCEEEECCHHHHHHHHH
IYKQQGIEILSANSPLDPYLINFLENKLAPITFQRIDAEVHENLVDKSREKTVLDAEGRT
HHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCH
EATKLAEFVQTKLNDDNVEVQAKSLASDSLPGFIVIDEKQRRMREYMMRLDPEERNIQMS
HHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEE
LFNKKTFVINTNNSLFESIQKLDQQNPNLAKDLTQEVYELALLSQREMEPHSLHEFVNRS
EECCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NRVLEALTKEALKNT
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKGSLQIHSENILPIIKKWLYSDKDIFMRELVSNSCDAIQKVKILRDQGDVEVKDEDFR
CCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCEE
IDIQIDKETRILKFIDNGIGMDAEEVKKYIAQIAFSGAEEFLNKYQSNQESEQIIGHFGL
EEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH
GFYSAYMVADKVEINTLSYKNEAEPVLWICDGSSDYEMDRGTKSSRGTEITLFISKDSDE
HHHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHH
YLDKEHLKKILIHYCSFLPYPIYLDGQRINEFEPLWIKSASDCTKEDYLNFYHQLFPLEE
HCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCC
DPLFWVHLNVDYPFRLKGILYFPKIKRDFDMNKSHVSLYCNRVFVSDNCKDLIPNYLSVL
CCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHH
KGIIDSPDIPLNVSRSYLQMDRTVRQLASHISKKVSDSLSTLYKTDRERFIQAWQDSSVI
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VKLGILEDDKFYERAKEFLIWKNTDQEWLTIPDYLERNKEKTKDKVFYATDEKIGAHMMD
EEEEECCCHHHHHHHHHEEEECCCCCCCEECCHHHHCCHHHCCCCEEEECCHHHHHHHHH
IYKQQGIEILSANSPLDPYLINFLENKLAPITFQRIDAEVHENLVDKSREKTVLDAEGRT
HHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCH
EATKLAEFVQTKLNDDNVEVQAKSLASDSLPGFIVIDEKQRRMREYMMRLDPEERNIQMS
HHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEE
LFNKKTFVINTNNSLFESIQKLDQQNPNLAKDLTQEVYELALLSQREMEPHSLHEFVNRS
EECCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NRVLEALTKEALKNT
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]