Click here to switch to the map view.

The map label for this gene is aac [H]

Identifier: 46446970

GI number: 46446970

Start: 1593412

End: 1593912

Strand: Direct

Name: aac [H]

Synonym: pc1336

Alternate gene names: 46446970

Gene position: 1593412-1593912 (Clockwise)

Preceding gene: 46446969

Following gene: 46446975

Centisome position: 65.99

GC content: 34.53

Gene sequence:

>501_bases
GTGCCATTAATTTATGCTTGGTTTCAAACCCCGCATATTAAAAAATGGTACGGATCGGAACAAGAATGGACAATTGAAGC
AATTGAAAAAAAATACAACCCTCATCGACTACAGGCCAATAAAATTGCTGCCTTCATCATTTATTACAAACAAATTCCAA
TAGGTTATATCCAAAAGTATTCTGTTAGCGATTATCCCTGGGAAGAGCTTGATTTGTCTAAACTTGCTTCTAAATTAGCA
GGAATAGATTTATTTATTGGAAACCCCACCTACCTTTATCAAGGCTTCGGGCAGCTTATTTTAAAACAATTTTTAACCCA
ACAGATTCAACCTTACTTTCAAGAATGTTTAGTGGATCCTCGTTGTGATAATTATGCTGCTATTCGCTGTTATGAAAAAG
TCGGTTTTGAATTTTATCAAACTGTACTTTGTGGCCGAGAAGCACTTTGCATAATGAAAAAAAATTTAACGCATCATTTG
GTAGAGATACCAAAGAGTTAA

Upstream 100 bases:

>100_bases
TGGGGATCGATCTTATGATACTTTATTGTCCGCTCTAAAAAATGCTGTCAGCTGATATAAATCGATGAGGATTTACTTTC
AATTTTTAGAAAATCAACAT

Downstream 100 bases:

>100_bases
ATGTAAGTAACTCTATCACCTACACTTACAATTGCCCCAGAATATCTGGTGGCAATCATAGATTTTATTCAAATTAATGA
AGAAGTTCTTGAATTTCTTT

Product: putative aminoglycoside N6'-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MPLIYAWFQTPHIKKWYGSEQEWTIEAIEKKYNPHRLQANKIAAFIIYYKQIPIGYIQKYSVSDYPWEELDLSKLASKLA
GIDLFIGNPTYLYQGFGQLILKQFLTQQIQPYFQECLVDPRCDNYAAIRCYEKVGFEFYQTVLCGREALCIMKKNLTHHL
VEIPKS

Sequences:

>Translated_166_residues
MPLIYAWFQTPHIKKWYGSEQEWTIEAIEKKYNPHRLQANKIAAFIIYYKQIPIGYIQKYSVSDYPWEELDLSKLASKLA
GIDLFIGNPTYLYQGFGQLILKQFLTQQIQPYFQECLVDPRCDNYAAIRCYEKVGFEFYQTVLCGREALCIMKKNLTHHL
VEIPKS
>Mature_165_residues
PLIYAWFQTPHIKKWYGSEQEWTIEAIEKKYNPHRLQANKIAAFIIYYKQIPIGYIQKYSVSDYPWEELDLSKLASKLAG
IDLFIGNPTYLYQGFGQLILKQFLTQQIQPYFQECLVDPRCDNYAAIRCYEKVGFEFYQTVLCGREALCIMKKNLTHHLV
EIPKS

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 19603; Mature: 19472

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIYAWFQTPHIKKWYGSEQEWTIEAIEKKYNPHRLQANKIAAFIIYYKQIPIGYIQKY
CCEEEEECCCCCCHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHEEEEEHHHCCHHHHEEC
SVSDYPWEELDLSKLASKLAGIDLFIGNPTYLYQGFGQLILKQFLTQQIQPYFQECLVDP
CCCCCCHHHCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RCDNYAAIRCYEKVGFEFYQTVLCGREALCIMKKNLTHHLVEIPKS
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLIYAWFQTPHIKKWYGSEQEWTIEAIEKKYNPHRLQANKIAAFIIYYKQIPIGYIQKY
CEEEEECCCCCCHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHEEEEEHHHCCHHHHEEC
SVSDYPWEELDLSKLASKLAGIDLFIGNPTYLYQGFGQLILKQFLTQQIQPYFQECLVDP
CCCCCCHHHCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RCDNYAAIRCYEKVGFEFYQTVLCGREALCIMKKNLTHHLVEIPKS
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]