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The map label for this gene is groEl

Identifier: 46446893

GI number: 46446893

Start: 1501351

End: 1502955

Strand: Direct

Name: groEl

Synonym: pc1259

Alternate gene names: 46446893

Gene position: 1501351-1502955 (Clockwise)

Preceding gene: 46446892

Following gene: 46446895

Centisome position: 62.18

GC content: 39.56

Gene sequence:

>1605_bases
ATGTCAATACCTAAAGAAATTATTTTTGAAGAGGAAGCACGGGAATTTCTTTTAAAGGGAATCAAGAAATTAGCCGATGT
TGTTGCCTTCACCCTTGGCCCTAAAGGAAGAAATGTAGGTCTTGAAAAAAGTTGGGGAGCTCCCACAATCACAAACGACG
GCGCAAGCATCATTCGAGATATTCAACTCGAAGACAAATACGAAAATATGGGCGTTGCAATGGCAAAAGAAGTCGTCCAA
AAAATTAAAGAAAAGTGTGGAGATGGAACAACAAGTGGAGCTCTACTTTTAAGATCTTTAGTGGAAGCCGGTATAAAAAA
TATTTCTTCTGGAGCAAGTCCAATCGGAATTAAAAGAGGGATGGATAAAGCTGTTGAAGTTGTTGTAAAAGCAATTGAAA
AGGCAGCTATTCCAGTTAAAACAAAACAAGAAACAAGAAACGTTGCTGTTGTTTCCGCTTCCGGTAATCAAGAAATTGGC
GAATTAATTGCAGAAGCGATGGAAAAAGTGAGTAATTCCGGCGCTATTACAATCGAAGAAGGAAAGGGTACCGAAACAAG
TATAGAAGTTGTCAAAGGGATGAAATTTGATCGTGGTTATGTCAGTCCTTACCTTTGCACGAACCTCGAAAAAATGATTG
TTGAAATGGATCATGCTCAAATCCTCCTCGTTGATAAAAAAATTTCTAGTATTCATGAATTACTTCCTGTGCTTCAAGCT
ACGGCTGCATCAGGACGCGAACTTTTAATCATTGCCGAAGATATTGACGGAGATGCATTGTCAACACTAGTCGTCAATAA
ACTTCGTGGTACTCTAAAAGTAGCTGCTGTTAAAGCCCCAGGGTTTGGCGATCGTCGTAAAGCAATGCTTCAAGATATTG
CAACGTTAACAGCCGCTACGGTTGTTTCTGAAGAACTTGGCATTTCTTTAAAAGAAATTCCAGCAACAGCTTTAGGATCA
GCAGAAAAAGTAACTGTCACGAAAGAATCAACAACGATTGTTGGTGGAACAGGAGCTCAAGAAGATATCGCTGCAAGAAT
TAAACAAATTGATGCCGAAATTAACTTGGCACAAAGTTCTTATGATAAAGAAAAACTAGAAGAGCGACGAGCTAAATTGA
GTGGTGGCGTTGCTGTTATTCGAGTAGGTGCGGCGACAGAGACTGAAATGAAGCAGAAAAAACAAATGTTTGATGATAGC
TTAAATTCAACAAAAGCTGCTTTAGAAGAAGGAATTGTTCCGGGTGGAGGAGTTGCTTTACTAAACGCAAGTAAAACGTT
GGGCCAACTAAAACTAGAAGGCGATGAAGCGGTAGGAGCTAAAATTGTTTTGCAGGCTTGCGAAACACCTATTAAACAAA
TTGTGCAAAATACCGGTTTTGATGGAAGTGTCGTCTTAAATGAAGTCCTCAATTCTCCTGCCAATTTCGGATTTAATGCT
TTAACTGAAAAAGTCGAAGACTTAATTGCCGCTGGCGTGATAGATCCTGCCAAAGTCATTAAAAATACGCTTACCTACGC
AGCATCAACTGCCGGTATTGTGCTTCTTTCTGAAGCATTGATCGCAGATGCGGATGATGAAGAAGAAGAAAACTCTACTA
AATAA

Upstream 100 bases:

>100_bases
TAAACTTTTTTGCGTCATTTAAATGACTTGCAAGGTGAGAAATTGAAATCTTACTTTGAGCGAAAATTCGATAGATAAGA
AATTTTAAAGAGGAGCTCAT

Downstream 100 bases:

>100_bases
GTATAGTCTTGGGAGTTTGCAAAATCATTTTTTAGCAAACTTCCAAAACTTTATTCTTAGAACAGAAAATGATCCAACAA
GAATAGCTTCTAATGATAGA

Product: heat shock protein GroEL

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSIPKEIIFEEEAREFLLKGIKKLADVVAFTLGPKGRNVGLEKSWGAPTITNDGASIIRDIQLEDKYENMGVAMAKEVVQ
KIKEKCGDGTTSGALLLRSLVEAGIKNISSGASPIGIKRGMDKAVEVVVKAIEKAAIPVKTKQETRNVAVVSASGNQEIG
ELIAEAMEKVSNSGAITIEEGKGTETSIEVVKGMKFDRGYVSPYLCTNLEKMIVEMDHAQILLVDKKISSIHELLPVLQA
TAASGRELLIIAEDIDGDALSTLVVNKLRGTLKVAAVKAPGFGDRRKAMLQDIATLTAATVVSEELGISLKEIPATALGS
AEKVTVTKESTTIVGGTGAQEDIAARIKQIDAEINLAQSSYDKEKLEERRAKLSGGVAVIRVGAATETEMKQKKQMFDDS
LNSTKAALEEGIVPGGGVALLNASKTLGQLKLEGDEAVGAKIVLQACETPIKQIVQNTGFDGSVVLNEVLNSPANFGFNA
LTEKVEDLIAAGVIDPAKVIKNTLTYAASTAGIVLLSEALIADADDEEEENSTK

Sequences:

>Translated_534_residues
MSIPKEIIFEEEAREFLLKGIKKLADVVAFTLGPKGRNVGLEKSWGAPTITNDGASIIRDIQLEDKYENMGVAMAKEVVQ
KIKEKCGDGTTSGALLLRSLVEAGIKNISSGASPIGIKRGMDKAVEVVVKAIEKAAIPVKTKQETRNVAVVSASGNQEIG
ELIAEAMEKVSNSGAITIEEGKGTETSIEVVKGMKFDRGYVSPYLCTNLEKMIVEMDHAQILLVDKKISSIHELLPVLQA
TAASGRELLIIAEDIDGDALSTLVVNKLRGTLKVAAVKAPGFGDRRKAMLQDIATLTAATVVSEELGISLKEIPATALGS
AEKVTVTKESTTIVGGTGAQEDIAARIKQIDAEINLAQSSYDKEKLEERRAKLSGGVAVIRVGAATETEMKQKKQMFDDS
LNSTKAALEEGIVPGGGVALLNASKTLGQLKLEGDEAVGAKIVLQACETPIKQIVQNTGFDGSVVLNEVLNSPANFGFNA
LTEKVEDLIAAGVIDPAKVIKNTLTYAASTAGIVLLSEALIADADDEEEENSTK
>Mature_533_residues
SIPKEIIFEEEAREFLLKGIKKLADVVAFTLGPKGRNVGLEKSWGAPTITNDGASIIRDIQLEDKYENMGVAMAKEVVQK
IKEKCGDGTTSGALLLRSLVEAGIKNISSGASPIGIKRGMDKAVEVVVKAIEKAAIPVKTKQETRNVAVVSASGNQEIGE
LIAEAMEKVSNSGAITIEEGKGTETSIEVVKGMKFDRGYVSPYLCTNLEKMIVEMDHAQILLVDKKISSIHELLPVLQAT
AASGRELLIIAEDIDGDALSTLVVNKLRGTLKVAAVKAPGFGDRRKAMLQDIATLTAATVVSEELGISLKEIPATALGSA
EKVTVTKESTTIVGGTGAQEDIAARIKQIDAEINLAQSSYDKEKLEERRAKLSGGVAVIRVGAATETEMKQKKQMFDDSL
NSTKAALEEGIVPGGGVALLNASKTLGQLKLEGDEAVGAKIVLQACETPIKQIVQNTGFDGSVVLNEVLNSPANFGFNAL
TEKVEDLIAAGVIDPAKVIKNTLTYAASTAGIVLLSEALIADADDEEEENSTK

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=41.2878787878788, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=41.2878787878788, Blast_Score=425, Evalue=1e-119,
Organism=Escherichia coli, GI1790586, Length=520, Percent_Identity=50.7692307692308, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=43.2075471698113, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=42.8571428571429, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=46.0227272727273, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24641193, Length=531, Percent_Identity=43.1261770244821, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24641191, Length=531, Percent_Identity=43.1261770244821, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=41.06463878327, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=41.06463878327, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=41.06463878327, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17864606, Length=527, Percent_Identity=37.3814041745731, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24584129, Length=524, Percent_Identity=31.6793893129771, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI19921262, Length=524, Percent_Identity=31.6793893129771, Blast_Score=256, Evalue=4e-68,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH603_PARUW (Q6MBR6)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008258.1
- ProteinModelPortal:   Q6MBR6
- SMR:   Q6MBR6
- STRING:   Q6MBR6
- GeneID:   2780168
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1259
- NMPDR:   fig|264201.1.peg.1259
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- ProtClustDB:   CLSK2762363
- BioCyc:   CPRO264201:PC1259-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56481; Mature: 56349

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPKEIIFEEEAREFLLKGIKKLADVVAFTLGPKGRNVGLEKSWGAPTITNDGASIIRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IQLEDKYENMGVAMAKEVVQKIKEKCGDGTTSGALLLRSLVEAGIKNISSGASPIGIKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
MDKAVEVVVKAIEKAAIPVKTKQETRNVAVVSASGNQEIGELIAEAMEKVSNSGAITIEE
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEC
GKGTETSIEVVKGMKFDRGYVSPYLCTNLEKMIVEMDHAQILLVDKKISSIHELLPVLQA
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
TAASGRELLIIAEDIDGDALSTLVVNKLRGTLKVAAVKAPGFGDRRKAMLQDIATLTAAT
HHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VVSEELGISLKEIPATALGSAEKVTVTKESTTIVGGTGAQEDIAARIKQIDAEINLAQSS
HHHHHHCCCHHHCCCHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YDKEKLEERRAKLSGGVAVIRVGAATETEMKQKKQMFDDSLNSTKAALEEGIVPGGGVAL
CCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEE
LNASKTLGQLKLEGDEAVGAKIVLQACETPIKQIVQNTGFDGSVVLNEVLNSPANFGFNA
EECCHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
LTEKVEDLIAAGVIDPAKVIKNTLTYAASTAGIVLLSEALIADADDEEEENSTK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SIPKEIIFEEEAREFLLKGIKKLADVVAFTLGPKGRNVGLEKSWGAPTITNDGASIIRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IQLEDKYENMGVAMAKEVVQKIKEKCGDGTTSGALLLRSLVEAGIKNISSGASPIGIKRG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
MDKAVEVVVKAIEKAAIPVKTKQETRNVAVVSASGNQEIGELIAEAMEKVSNSGAITIEE
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEC
GKGTETSIEVVKGMKFDRGYVSPYLCTNLEKMIVEMDHAQILLVDKKISSIHELLPVLQA
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
TAASGRELLIIAEDIDGDALSTLVVNKLRGTLKVAAVKAPGFGDRRKAMLQDIATLTAAT
HHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
VVSEELGISLKEIPATALGSAEKVTVTKESTTIVGGTGAQEDIAARIKQIDAEINLAQSS
HHHHHHCCCHHHCCCHHCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YDKEKLEERRAKLSGGVAVIRVGAATETEMKQKKQMFDDSLNSTKAALEEGIVPGGGVAL
CCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEE
LNASKTLGQLKLEGDEAVGAKIVLQACETPIKQIVQNTGFDGSVVLNEVLNSPANFGFNA
EECCHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHH
LTEKVEDLIAAGVIDPAKVIKNTLTYAASTAGIVLLSEALIADADDEEEENSTK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA