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The map label for this gene is oprM [H]

Identifier: 46446853

GI number: 46446853

Start: 1449808

End: 1451268

Strand: Direct

Name: oprM [H]

Synonym: pc1219

Alternate gene names: 46446853

Gene position: 1449808-1451268 (Clockwise)

Preceding gene: 46446852

Following gene: 46446854

Centisome position: 60.05

GC content: 34.29

Gene sequence:

>1461_bases
ATGCGGATTAACTTTTTTTCTTTTTTAATTTTTACAAGTTTATTAACGAGTTGCTGTTCTCATAGAAGCTATGTTCCACC
TTCACTTGATATCCCTTATGAATGGAATAGCCCTCTTTCTGACGGAATGCATACAAATTCGCCCAAACACCTTATTTGGT
GGGAATCATTAAATGATCCTATATTAAATCGATTAATAAAATTAGCTGCTTTTCAAAATCTAGATCTCTATCTTGCCGGA
ACAAGAATTCTCGAAGCTAGACTACAAAGAAAAGGTAAAAATAGCGATTTATATCCACATGTAGATATGTCTTGTAGTTA
CAGTCATATAGAATCTCATCAAAACGTAGTCTTGAATAGGATTTTAAAACATTCTCAAAATAAACTAAAAACCAATTCCT
CTAAGTTAAATTTATTTGAAATTGGTTTTGATGCAGATTGGGAAATTGATTTATTTCAATCAAATCAATATGAAATGAAT
GCGTTAGAAGCACAAATTGAAGCCAACGAGGAAAATTTTAATGACATATGGGTGACTCTTTCAGCTGAAATTGGAAGAAA
TTATATTGAACTAAGACATTTACAGCATAAATTGATTCTCCTCAATAAACAGATTGAATCTCAAGCTGATATTCTTCATC
TAACCGAAGAACTTCTCCAAATCGGAATGGCAAATTCGATTGATATTTTGACTGCCACACAACAACTGGCCACTCTAAAA
GCTCGAAAACCCGTTATTGAATTCTCTATTCAAAAAACAATCTATCATTTATCGATTCTGCTCGGACAATTTCCAGGGGA
AGTGGAAGGACTCCTGGAATTTTCTAATCTTCCTTGTTTACCTGTTGAAAAACCTATCGGTATTCCTTCAGAATTATTGA
GAAGGCGGCCAGACATTAGGCGAGCTGAGCGACAATTGGCAACAGCCACAGAAAGTATTGGAAGCGCAGAAGCTGCTCTC
TTCCCCAAACTTTCCTTAAAAGGATTTGTCGGAATGGTTACACCTCATTTAAAATCCATTCTCAACCCAACAATGGTCAG
TACATGGTTTGCAAATCCTCAGCTTTTAATGCCTATTTTTAATAGCCGTTTATTGAAACGAGATGTTGATTATCATAAAC
TTAAAACCAAGCAAGCTTTATTTGAATACCAGAAGACAGTTTTAGAGGCATTAGAAGAAACTGAAAATGCTATTGCTTCT
TTTCACTACGAATTAGAGCGTCATCAACAACTTTCTGTTGCTTACTCCGCCGCTCAAGAAACCCAAAGAGGCACTTTAGA
GCTTTATCTAAAAGGATTTAAAAATTATTTAGAAGTTCAATTTACTAATCGAGCTCTCATAGAATTAGAAGAAGCTTTTA
ATGAAAGCCAGATGCAATTAATTCTTCACTATATTGCTCTTTATAAATCCTTAGGAGGAGGATGGAATTTTTTAGAAGAT
TCAAAAGAGCAATCATCTTAA

Upstream 100 bases:

>100_bases
GTTAAAAGTGACTTACCGCTTTAAGGAAAATGATCAAAATATTTTTGTTGGACAGGTGATGGATGTTTTTATTCAAGCTG
AATACCCTTGGAAATAAGAA

Downstream 100 bases:

>100_bases
TAGAAAAACAAGATTTTTCCGAATTTTTAATTGAGTAATTCTTATTGAAATGCTATGCATTACCAAACATATTCTAGAAA
AAATTAGTAAATTCTCTCTC

Product: putative outer membrane protein of AcrAB(MexAB)-OprM multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRINFFSFLIFTSLLTSCCSHRSYVPPSLDIPYEWNSPLSDGMHTNSPKHLIWWESLNDPILNRLIKLAAFQNLDLYLAG
TRILEARLQRKGKNSDLYPHVDMSCSYSHIESHQNVVLNRILKHSQNKLKTNSSKLNLFEIGFDADWEIDLFQSNQYEMN
ALEAQIEANEENFNDIWVTLSAEIGRNYIELRHLQHKLILLNKQIESQADILHLTEELLQIGMANSIDILTATQQLATLK
ARKPVIEFSIQKTIYHLSILLGQFPGEVEGLLEFSNLPCLPVEKPIGIPSELLRRRPDIRRAERQLATATESIGSAEAAL
FPKLSLKGFVGMVTPHLKSILNPTMVSTWFANPQLLMPIFNSRLLKRDVDYHKLKTKQALFEYQKTVLEALEETENAIAS
FHYELERHQQLSVAYSAAQETQRGTLELYLKGFKNYLEVQFTNRALIELEEAFNESQMQLILHYIALYKSLGGGWNFLED
SKEQSS

Sequences:

>Translated_486_residues
MRINFFSFLIFTSLLTSCCSHRSYVPPSLDIPYEWNSPLSDGMHTNSPKHLIWWESLNDPILNRLIKLAAFQNLDLYLAG
TRILEARLQRKGKNSDLYPHVDMSCSYSHIESHQNVVLNRILKHSQNKLKTNSSKLNLFEIGFDADWEIDLFQSNQYEMN
ALEAQIEANEENFNDIWVTLSAEIGRNYIELRHLQHKLILLNKQIESQADILHLTEELLQIGMANSIDILTATQQLATLK
ARKPVIEFSIQKTIYHLSILLGQFPGEVEGLLEFSNLPCLPVEKPIGIPSELLRRRPDIRRAERQLATATESIGSAEAAL
FPKLSLKGFVGMVTPHLKSILNPTMVSTWFANPQLLMPIFNSRLLKRDVDYHKLKTKQALFEYQKTVLEALEETENAIAS
FHYELERHQQLSVAYSAAQETQRGTLELYLKGFKNYLEVQFTNRALIELEEAFNESQMQLILHYIALYKSLGGGWNFLED
SKEQSS
>Mature_486_residues
MRINFFSFLIFTSLLTSCCSHRSYVPPSLDIPYEWNSPLSDGMHTNSPKHLIWWESLNDPILNRLIKLAAFQNLDLYLAG
TRILEARLQRKGKNSDLYPHVDMSCSYSHIESHQNVVLNRILKHSQNKLKTNSSKLNLFEIGFDADWEIDLFQSNQYEMN
ALEAQIEANEENFNDIWVTLSAEIGRNYIELRHLQHKLILLNKQIESQADILHLTEELLQIGMANSIDILTATQQLATLK
ARKPVIEFSIQKTIYHLSILLGQFPGEVEGLLEFSNLPCLPVEKPIGIPSELLRRRPDIRRAERQLATATESIGSAEAAL
FPKLSLKGFVGMVTPHLKSILNPTMVSTWFANPQLLMPIFNSRLLKRDVDYHKLKTKQALFEYQKTVLEALEETENAIAS
FHYELERHQQLSVAYSAAQETQRGTLELYLKGFKNYLEVQFTNRALIELEEAFNESQMQLILHYIALYKSLGGGWNFLED
SKEQSS

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=466, Percent_Identity=23.6051502145923, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI2367348, Length=493, Percent_Identity=21.9066937119675, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55853; Mature: 55853

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRINFFSFLIFTSLLTSCCSHRSYVPPSLDIPYEWNSPLSDGMHTNSPKHLIWWESLNDP
CEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
ILNRLIKLAAFQNLDLYLAGTRILEARLQRKGKNSDLYPHVDMSCSYSHIESHQNVVLNR
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILKHSQNKLKTNSSKLNLFEIGFDADWEIDLFQSNQYEMNALEAQIEANEENFNDIWVTL
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHEECCCCCCCEEEEEE
SAEIGRNYIELRHLQHKLILLNKQIESQADILHLTEELLQIGMANSIDILTATQQLATLK
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ARKPVIEFSIQKTIYHLSILLGQFPGEVEGLLEFSNLPCLPVEKPIGIPSELLRRRPDIR
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHH
RAERQLATATESIGSAEAALFPKLSLKGFVGMVTPHLKSILNPTMVSTWFANPQLLMPIF
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHH
NSRLLKRDVDYHKLKTKQALFEYQKTVLEALEETENAIASFHYELERHQQLSVAYSAAQE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQRGTLELYLKGFKNYLEVQFTNRALIELEEAFNESQMQLILHYIALYKSLGGGWNFLED
HCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCC
SKEQSS
CCCCCC
>Mature Secondary Structure
MRINFFSFLIFTSLLTSCCSHRSYVPPSLDIPYEWNSPLSDGMHTNSPKHLIWWESLNDP
CEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
ILNRLIKLAAFQNLDLYLAGTRILEARLQRKGKNSDLYPHVDMSCSYSHIESHQNVVLNR
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILKHSQNKLKTNSSKLNLFEIGFDADWEIDLFQSNQYEMNALEAQIEANEENFNDIWVTL
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHEECCCCCCCEEEEEE
SAEIGRNYIELRHLQHKLILLNKQIESQADILHLTEELLQIGMANSIDILTATQQLATLK
EHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ARKPVIEFSIQKTIYHLSILLGQFPGEVEGLLEFSNLPCLPVEKPIGIPSELLRRRPDIR
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHH
RAERQLATATESIGSAEAALFPKLSLKGFVGMVTPHLKSILNPTMVSTWFANPQLLMPIF
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHH
NSRLLKRDVDYHKLKTKQALFEYQKTVLEALEETENAIASFHYELERHQQLSVAYSAAQE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQRGTLELYLKGFKNYLEVQFTNRALIELEEAFNESQMQLILHYIALYKSLGGGWNFLED
HCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCC
SKEQSS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]