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The map label for this gene is cyoE

Identifier: 46446827

GI number: 46446827

Start: 1421484

End: 1422335

Strand: Direct

Name: cyoE

Synonym: pc1193

Alternate gene names: 46446827

Gene position: 1421484-1422335 (Clockwise)

Preceding gene: 46446826

Following gene: 46446828

Centisome position: 58.87

GC content: 34.51

Gene sequence:

>852_bases
ATGATTAACTACTATTTATTATTGACTAAGCCAGGAATTATTCTTGGCAACCTCGTCACAGTGATGGCCGGTTTTTTATT
AGCTTCAAAAGGGCAATTTCAATTTGGACTTTTTTTTTCAACAATCCTGGGTTTAGCTTTCATCATGGCTTCTGGATGTG
TATTTAATAACTACATTGATCTTGAAAAAGATCGACTTATGAAACGAACTCAGAACAGACCTCTTGTTATAGGAGTAATT
TTTGAAAAACAAGCTATTGTATTTGGATTAGCTTTAGCAATCGTTGGAGCTATTATTTTATATTTCTATACCAATCTTTT
AACGCTAGTTATCGCTGAATTGGGATTTATTATTTATGTTTTCTTTTATAGTATTTGGAAAAGTCGGACAGTTTACGGAA
CGGCGATAGGAAGCCTAGCAGGAGCTGTTCCACCTCTTGTTGGTTATTGTGCAGTCAGCAATCAATTAGATTTAGGAGCT
TTTATTTTATTTGCCATGATGGTGTTTTGGCAAATGCCCCATTTTTTTTCTATTGCTATTTATCGTCTGCAAGACTATTC
GGCAGCTAACATTCCAGTTTTACCTCTGAAAAAAGGAATTCAAATAACGAAAATTCGCATCCTTTTGTATATTATTATCT
TCACATTGACATCCAGCTTATTGACATTTTTCCATTTTACCGGATCTCTTTATTTGATTCTGACAATCGGATTAGGTCTG
ACATGGCTACTCATGGGATTGAGAGGTTTAAAAACTTCTAATGATCAACAATGGGCACAACAGATGTTTCGTTTTTCTCT
TGTTATCATCAGTGTTCTTTCTCTAACCATCCCATTCGATTTGGTAAACTAA

Upstream 100 bases:

>100_bases
TTTACAATATTAATTTTACTCATCGTCGTTATCGGATCACTTTGGATTATGCATGATTTGAATGAACGCATGATGGGGTA
TATGACCCAAGAAATGACAC

Downstream 100 bases:

>100_bases
AAAATGCAATTTACTTTAACGGGCCCTAAAGGGCTTTTCTTGCCACCCTATTTTAGAAAGCTGGGAAGAGGAAAAGAGAC
GAGAAATAATGTTCTGCCGA

Product: heme O synthase (protoheme IX farnesyltransferase) CyoE

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MINYYLLLTKPGIILGNLVTVMAGFLLASKGQFQFGLFFSTILGLAFIMASGCVFNNYIDLEKDRLMKRTQNRPLVIGVI
FEKQAIVFGLALAIVGAIILYFYTNLLTLVIAELGFIIYVFFYSIWKSRTVYGTAIGSLAGAVPPLVGYCAVSNQLDLGA
FILFAMMVFWQMPHFFSIAIYRLQDYSAANIPVLPLKKGIQITKIRILLYIIIFTLTSSLLTFFHFTGSLYLILTIGLGL
TWLLMGLRGLKTSNDQQWAQQMFRFSLVIISVLSLTIPFDLVN

Sequences:

>Translated_283_residues
MINYYLLLTKPGIILGNLVTVMAGFLLASKGQFQFGLFFSTILGLAFIMASGCVFNNYIDLEKDRLMKRTQNRPLVIGVI
FEKQAIVFGLALAIVGAIILYFYTNLLTLVIAELGFIIYVFFYSIWKSRTVYGTAIGSLAGAVPPLVGYCAVSNQLDLGA
FILFAMMVFWQMPHFFSIAIYRLQDYSAANIPVLPLKKGIQITKIRILLYIIIFTLTSSLLTFFHFTGSLYLILTIGLGL
TWLLMGLRGLKTSNDQQWAQQMFRFSLVIISVLSLTIPFDLVN
>Mature_283_residues
MINYYLLLTKPGIILGNLVTVMAGFLLASKGQFQFGLFFSTILGLAFIMASGCVFNNYIDLEKDRLMKRTQNRPLVIGVI
FEKQAIVFGLALAIVGAIILYFYTNLLTLVIAELGFIIYVFFYSIWKSRTVYGTAIGSLAGAVPPLVGYCAVSNQLDLGA
FILFAMMVFWQMPHFFSIAIYRLQDYSAANIPVLPLKKGIQITKIRILLYIIIFTLTSSLLTFFHFTGSLYLILTIGLGL
TWLLMGLRGLKTSNDQQWAQQMFRFSLVIISVLSLTIPFDLVN

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=33.9285714285714, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786631, Length=281, Percent_Identity=48.0427046263345, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71998235, Length=204, Percent_Identity=28.921568627451, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=239, Percent_Identity=28.4518828451883, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921064, Length=258, Percent_Identity=27.5193798449612, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_PARUW (Q6MBY2)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008192.1
- STRING:   Q6MBY2
- GeneID:   2781407
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1193
- NMPDR:   fig|264201.1.peg.1193
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- PhylomeDB:   Q6MBY2
- ProtClustDB:   CLSK2762350
- BioCyc:   CPRO264201:PC1193-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 31732; Mature: 31732

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc4b5558)-; HASH(0xe4cc38c)-; HASH(0xe4c7500)-; HASH(0xe4cc278)-; HASH(0xe4cc0a4)-; HASH(0xe1f7828)-; HASH(0xe4a3494)-; HASH(0xe4984fc)-; HASH(0xe4c9ed4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINYYLLLTKPGIILGNLVTVMAGFLLASKGQFQFGLFFSTILGLAFIMASGCVFNNYID
CCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEKDRLMKRTQNRPLVIGVIFEKQAIVFGLALAIVGAIILYFYTNLLTLVIAELGFIIYV
CCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFYSIWKSRTVYGTAIGSLAGAVPPLVGYCAVSNQLDLGAFILFAMMVFWQMPHFFSIAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
YRLQDYSAANIPVLPLKKGIQITKIRILLYIIIFTLTSSLLTFFHFTGSLYLILTIGLGL
HHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWLLMGLRGLKTSNDQQWAQQMFRFSLVIISVLSLTIPFDLVN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCH
>Mature Secondary Structure
MINYYLLLTKPGIILGNLVTVMAGFLLASKGQFQFGLFFSTILGLAFIMASGCVFNNYID
CCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEKDRLMKRTQNRPLVIGVIFEKQAIVFGLALAIVGAIILYFYTNLLTLVIAELGFIIYV
CCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFYSIWKSRTVYGTAIGSLAGAVPPLVGYCAVSNQLDLGAFILFAMMVFWQMPHFFSIAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
YRLQDYSAANIPVLPLKKGIQITKIRILLYIIIFTLTSSLLTFFHFTGSLYLILTIGLGL
HHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TWLLMGLRGLKTSNDQQWAQQMFRFSLVIISVLSLTIPFDLVN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA