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The map label for this gene is cyoB [H]

Identifier: 46446824

GI number: 46446824

Start: 1418523

End: 1420484

Strand: Direct

Name: cyoB [H]

Synonym: pc1190

Alternate gene names: 46446824

Gene position: 1418523-1420484 (Clockwise)

Preceding gene: 46446823

Following gene: 46446825

Centisome position: 58.75

GC content: 37.82

Gene sequence:

>1962_bases
ATGTTTGGTAAACTTACTTTAGAATCTTTTAAACATGAATCCAGTCAAAATTTTGCTGTAGTGATGATGCTTATTAGCGG
TATCGCTTTGATTGGCCTGATTTTTTATCTTAAAAGATGGAAATGGCTTTGGAATGAATGGATCACGACAGTTGATCCCA
AACGCATCGGAATTATGTATATTATTGTTGTATTGATCATGTTTTTTAAAGGATTTACAGATGCTTTAATGATTAGATTG
CAACAAGCCTTATCTGTCGGAGAATCTCAAGGGTTTATTTCTTCTACACATTTTCAAGAAGTTTTTTCTGCCCATGGAAC
AACAATGATCTTTTTTGTAGCCATGGGAGCAGTCTTTGGGCTTTTAAATTTAATTATTCCTTTGCAAATCGGCGCTAGAG
ACGTTGCTTTCCCCTTCTTAAATGCGGTTAGCTTTTGGCTTTTTACAGCCGGGGCAATGCTAACACTCATTTCACTTGCC
ATTGGTCAATTTTCAATAGCCGGATGGTTAGCCTATCCTCCTCTTTCGGCTCTAGAATACAGTCCCGGCGAAGGAGTTGA
TTACTGGATTTGGATGTTACAAATTTCAGGAATCGGAAGCACACTTTCCGGGATTAACTTTCTTGTAACCATCCTAAAAA
TGCGCTGTCCTGGAATGACTTTAATGAAGATGCCTATCTTTGTTTGGAGTAGTTTGTGCTCAATGGTTTTAATCATCTTT
GCCTTCCCAATTCTAACTGCAACTTTATTTATGTTTTCGCTAGATCGTTACCTAGACATGCACTTTTTTACGACTGGTGG
TGGAGGAAACCCGATGATGTATGTGAACTTGATTTGGGCATGGGGGCATCCGGAGGTCTATATTCTGATTTTACCCATTT
TTGGAGTTTTCTCTGAAATTGTTCCCACTTTTTCAGAAAAAAGGTTATTTGGGTATGTCTCTATGGTTTGGGCTCTCGTT
TTAATTGCTTTTTTCTCTTTTGTCGTTTGGGTCCACCATTTCTTTACAATGGGAGCTAGCCCACATGTCAATGCCCTTTT
CGGGATTTTGACGATGATTATCGCTATTCCAACAGGTGTTAAAATCTTTAATTGGCTCTTCACAAAATTTCGAGGGCGGG
TTCATTTTACCTCTCCCATGCTTTGGTTCTTCGCTTTCTTGTTAAATTTTACAATTGCTGGAATGACAGGTATTTTACTA
GCTTCCCCTCCCGTTGATTACCAAGTTCATAATAGTTTATTTTTAATTGCCCATTTTCATGGAATGGTAATTGGCGGTGT
TCTATTTGGATTTTTTGCGGGATTTACTTATTGGTTTCCTAAGTTTACGGGTTTTATGTTGGATGAAAAACTAAATAGAT
ATGCTTTTTGGTGTTGGCTAAGTGGATTTTTGCTAGCCTTTATGCCTCTTTATATGCTTGGTTTCATGGGGGCGACAAGA
CGATTAGACCACTATGACGTTTCGACAGGATGGCACCCTCTCTTCTTGATTGTTGCTTTTGGAGCTTTTATCATAGCATG
TGGAGCATTTATTCAATTTTTTGGATTATTTTGGAGTATTAAAAATCGCAAAAAGAATTGGGATAGTACAGGTGGCGATC
CATGGAATGGAAGAACTCTAGAATGGTCTATTCCTTCTCCTGTTCCCATTTATAATTTTGCCATTATTCCAACAGTCGAT
CAAATCGACCCTTTTTGGGCAATTAAGCGAGGTGTCGCACCCGAACAGAAAAAAAATTATGAAGATATTTATTTACCTAA
AAATACCCCTATGGCTTTTTATATAGGGACTTTAAGTTTGATTTTCGGATTTGCAATGACATGGCATATTTGGTGGCTTG
CTTTAGGAAGTTTTGTCGGAATTCTAGCTTGTCTGATTGTTCGATTATCTCACGATGATCCTCATGAAGTCATTACTGTT
GCTGAAATCAAAAAAATAGAAGCTTCCTATTCAAAGAGGTAA

Upstream 100 bases:

>100_bases
AGTAAAAACAATCCAGTAGAAATTTATCGATTAGAAGAAAATTCTCTTTTTGATCTAACAATTGATAAATACATGTACCC
TCAAAAGAAATAATTAAAAT

Downstream 100 bases:

>100_bases
TAAAACCAATGAGTTCATCTTTAATAGTTCATCATCAAGATACCCTTGATCGGCAACCCGATATTCGTGCTCCAGATCCA
CATCAAGATACATTTTCTAA

Product: cytochrome o ubiquinol oxidase chain I cyoB

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MFGKLTLESFKHESSQNFAVVMMLISGIALIGLIFYLKRWKWLWNEWITTVDPKRIGIMYIIVVLIMFFKGFTDALMIRL
QQALSVGESQGFISSTHFQEVFSAHGTTMIFFVAMGAVFGLLNLIIPLQIGARDVAFPFLNAVSFWLFTAGAMLTLISLA
IGQFSIAGWLAYPPLSALEYSPGEGVDYWIWMLQISGIGSTLSGINFLVTILKMRCPGMTLMKMPIFVWSSLCSMVLIIF
AFPILTATLFMFSLDRYLDMHFFTTGGGGNPMMYVNLIWAWGHPEVYILILPIFGVFSEIVPTFSEKRLFGYVSMVWALV
LIAFFSFVVWVHHFFTMGASPHVNALFGILTMIIAIPTGVKIFNWLFTKFRGRVHFTSPMLWFFAFLLNFTIAGMTGILL
ASPPVDYQVHNSLFLIAHFHGMVIGGVLFGFFAGFTYWFPKFTGFMLDEKLNRYAFWCWLSGFLLAFMPLYMLGFMGATR
RLDHYDVSTGWHPLFLIVAFGAFIIACGAFIQFFGLFWSIKNRKKNWDSTGGDPWNGRTLEWSIPSPVPIYNFAIIPTVD
QIDPFWAIKRGVAPEQKKNYEDIYLPKNTPMAFYIGTLSLIFGFAMTWHIWWLALGSFVGILACLIVRLSHDDPHEVITV
AEIKKIEASYSKR

Sequences:

>Translated_653_residues
MFGKLTLESFKHESSQNFAVVMMLISGIALIGLIFYLKRWKWLWNEWITTVDPKRIGIMYIIVVLIMFFKGFTDALMIRL
QQALSVGESQGFISSTHFQEVFSAHGTTMIFFVAMGAVFGLLNLIIPLQIGARDVAFPFLNAVSFWLFTAGAMLTLISLA
IGQFSIAGWLAYPPLSALEYSPGEGVDYWIWMLQISGIGSTLSGINFLVTILKMRCPGMTLMKMPIFVWSSLCSMVLIIF
AFPILTATLFMFSLDRYLDMHFFTTGGGGNPMMYVNLIWAWGHPEVYILILPIFGVFSEIVPTFSEKRLFGYVSMVWALV
LIAFFSFVVWVHHFFTMGASPHVNALFGILTMIIAIPTGVKIFNWLFTKFRGRVHFTSPMLWFFAFLLNFTIAGMTGILL
ASPPVDYQVHNSLFLIAHFHGMVIGGVLFGFFAGFTYWFPKFTGFMLDEKLNRYAFWCWLSGFLLAFMPLYMLGFMGATR
RLDHYDVSTGWHPLFLIVAFGAFIIACGAFIQFFGLFWSIKNRKKNWDSTGGDPWNGRTLEWSIPSPVPIYNFAIIPTVD
QIDPFWAIKRGVAPEQKKNYEDIYLPKNTPMAFYIGTLSLIFGFAMTWHIWWLALGSFVGILACLIVRLSHDDPHEVITV
AEIKKIEASYSKR
>Mature_653_residues
MFGKLTLESFKHESSQNFAVVMMLISGIALIGLIFYLKRWKWLWNEWITTVDPKRIGIMYIIVVLIMFFKGFTDALMIRL
QQALSVGESQGFISSTHFQEVFSAHGTTMIFFVAMGAVFGLLNLIIPLQIGARDVAFPFLNAVSFWLFTAGAMLTLISLA
IGQFSIAGWLAYPPLSALEYSPGEGVDYWIWMLQISGIGSTLSGINFLVTILKMRCPGMTLMKMPIFVWSSLCSMVLIIF
AFPILTATLFMFSLDRYLDMHFFTTGGGGNPMMYVNLIWAWGHPEVYILILPIFGVFSEIVPTFSEKRLFGYVSMVWALV
LIAFFSFVVWVHHFFTMGASPHVNALFGILTMIIAIPTGVKIFNWLFTKFRGRVHFTSPMLWFFAFLLNFTIAGMTGILL
ASPPVDYQVHNSLFLIAHFHGMVIGGVLFGFFAGFTYWFPKFTGFMLDEKLNRYAFWCWLSGFLLAFMPLYMLGFMGATR
RLDHYDVSTGWHPLFLIVAFGAFIIACGAFIQFFGLFWSIKNRKKNWDSTGGDPWNGRTLEWSIPSPVPIYNFAIIPTVD
QIDPFWAIKRGVAPEQKKNYEDIYLPKNTPMAFYIGTLSLIFGFAMTWHIWWLALGSFVGILACLIVRLSHDDPHEVITV
AEIKKIEASYSKR

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=513, Percent_Identity=37.2319688109162, Blast_Score=305, Evalue=9e-83,
Organism=Escherichia coli, GI1786634, Length=652, Percent_Identity=57.8220858895706, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=484, Percent_Identity=38.0165289256198, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=40.3669724770642, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=252, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74249; Mature: 74249

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLESFKHESSQNFAVVMMLISGIALIGLIFYLKRWKWLWNEWITTVDPKRIGIMY
CCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IIVVLIMFFKGFTDALMIRLQQALSVGESQGFISSTHFQEVFSAHGTTMIFFVAMGAVFG
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLNLIIPLQIGARDVAFPFLNAVSFWLFTAGAMLTLISLAIGQFSIAGWLAYPPLSALEY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SPGEGVDYWIWMLQISGIGSTLSGINFLVTILKMRCPGMTLMKMPIFVWSSLCSMVLIIF
CCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AFPILTATLFMFSLDRYLDMHFFTTGGGGNPMMYVNLIWAWGHPEVYILILPIFGVFSEI
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEEEECCCCEEEEHHHHHHHHHHH
VPTFSEKRLFGYVSMVWALVLIAFFSFVVWVHHFFTMGASPHVNALFGILTMIIAIPTGV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTKFRGRVHFTSPMLWFFAFLLNFTIAGMTGILLASPPVDYQVHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCEEEEHHHH
GMVIGGVLFGFFAGFTYWFPKFTGFMLDEKLNRYAFWCWLSGFLLAFMPLYMLGFMGATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RLDHYDVSTGWHPLFLIVAFGAFIIACGAFIQFFGLFWSIKNRKKNWDSTGGDPWNGRTL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
EWSIPSPVPIYNFAIIPTVDQIDPFWAIKRGVAPEQKKNYEDIYLPKNTPMAFYIGTLSL
EECCCCCCCEEEEEEECCHHHCCHHHHHHCCCCCCHHCCCCCEECCCCCCHHHHHHHHHH
IFGFAMTWHIWWLALGSFVGILACLIVRLSHDDPHEVITVAEIKKIEASYSKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MFGKLTLESFKHESSQNFAVVMMLISGIALIGLIFYLKRWKWLWNEWITTVDPKRIGIMY
CCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IIVVLIMFFKGFTDALMIRLQQALSVGESQGFISSTHFQEVFSAHGTTMIFFVAMGAVFG
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLNLIIPLQIGARDVAFPFLNAVSFWLFTAGAMLTLISLAIGQFSIAGWLAYPPLSALEY
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SPGEGVDYWIWMLQISGIGSTLSGINFLVTILKMRCPGMTLMKMPIFVWSSLCSMVLIIF
CCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AFPILTATLFMFSLDRYLDMHFFTTGGGGNPMMYVNLIWAWGHPEVYILILPIFGVFSEI
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEEEECCCCEEEEHHHHHHHHHHH
VPTFSEKRLFGYVSMVWALVLIAFFSFVVWVHHFFTMGASPHVNALFGILTMIIAIPTGV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
KIFNWLFTKFRGRVHFTSPMLWFFAFLLNFTIAGMTGILLASPPVDYQVHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCEEEEHHHH
GMVIGGVLFGFFAGFTYWFPKFTGFMLDEKLNRYAFWCWLSGFLLAFMPLYMLGFMGATR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RLDHYDVSTGWHPLFLIVAFGAFIIACGAFIQFFGLFWSIKNRKKNWDSTGGDPWNGRTL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
EWSIPSPVPIYNFAIIPTVDQIDPFWAIKRGVAPEQKKNYEDIYLPKNTPMAFYIGTLSL
EECCCCCCCEEEEEEECCHHHCCHHHHHHCCCCCCHHCCCCCEECCCCCCHHHHHHHHHH
IFGFAMTWHIWWLALGSFVGILACLIVRLSHDDPHEVITVAEIKKIEASYSKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]