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The map label for this gene is wzb [C]

Identifier: 46446713

GI number: 46446713

Start: 1289951

End: 1290433

Strand: Reverse

Name: wzb [C]

Synonym: pc1079

Alternate gene names: 46446713

Gene position: 1290433-1289951 (Counterclockwise)

Preceding gene: 46446714

Following gene: 46446712

Centisome position: 53.45

GC content: 36.44

Gene sequence:

>483_bases
ATGGAAACAATAAATGTACTCTTTGTCTGCATGGGCAATATTTGTAGGTCTCCTGCTGCGGAAGGAATTTTACGTCATTT
TGCAAAGAAAGAGCCCGATCTAGCCTTCCATATCGAAAGTTGTGGAATGGGAGATTGGCATGTTGGTCATAGTCCTGACG
TACGGATGCAAGAAGCTGCGAAATCAAGAGGAATCATTTTGACTAGTCAAGCTCAGCAATTTCAAAAAGAATTTTTTAAT
CGATTTGATTATATTTTAGTGGCAGATAAAGAAGTACTTGAATCACTTTATCAACATGCAAAATCTACTGAGCAAAAATC
TAAAATTATGTTCATGACAGAGTACAGTCAATTTTATCAAGGACAGGAAGTCCCAGACCCTTATTATCAACCGGGTGGTG
CTTTTGAATTAGTCCTTGATATTTTAGAAGATTCTTGTGTGGGTCTACTAAATCATATTCGAGTGAAAGAAGAAAAAAAA
TGA

Upstream 100 bases:

>100_bases
TGCGGCTGATGTGCAAATTTCTTAATAAATTGATTGTAAAGAAGAAAACCAAAGCTACAGCGATACTTTATAGTAAATTT
TAATTAGGAATAGATGAATG

Downstream 100 bases:

>100_bases
TAAGGATTGTCAAATACTCCCATTTTCTTTATGATTCCCCTTCTAATTTCAAGAGATGTTTAGGTTGAAAATGAAACTGT
TGTTATCTAAGCCCCGCGGT

Product: putative low molecular weight protein-tyrosine-phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
METINVLFVCMGNICRSPAAEGILRHFAKKEPDLAFHIESCGMGDWHVGHSPDVRMQEAAKSRGIILTSQAQQFQKEFFN
RFDYILVADKEVLESLYQHAKSTEQKSKIMFMTEYSQFYQGQEVPDPYYQPGGAFELVLDILEDSCVGLLNHIRVKEEKK

Sequences:

>Translated_160_residues
METINVLFVCMGNICRSPAAEGILRHFAKKEPDLAFHIESCGMGDWHVGHSPDVRMQEAAKSRGIILTSQAQQFQKEFFN
RFDYILVADKEVLESLYQHAKSTEQKSKIMFMTEYSQFYQGQEVPDPYYQPGGAFELVLDILEDSCVGLLNHIRVKEEKK
>Mature_160_residues
METINVLFVCMGNICRSPAAEGILRHFAKKEPDLAFHIESCGMGDWHVGHSPDVRMQEAAKSRGIILTSQAQQFQKEFFN
RFDYILVADKEVLESLYQHAKSTEQKSKIMFMTEYSQFYQGQEVPDPYYQPGGAFELVLDILEDSCVGLLNHIRVKEEKK

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=150, Percent_Identity=36.6666666666667, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI4757714, Length=150, Percent_Identity=34.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1788375, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI87081812, Length=142, Percent_Identity=31.6901408450704, Blast_Score=60, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6325330, Length=137, Percent_Identity=29.9270072992701, Blast_Score=72, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78706770, Length=155, Percent_Identity=32.9032258064516, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78706772, Length=155, Percent_Identity=32.9032258064516, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78711846, Length=160, Percent_Identity=33.75, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706766, Length=128, Percent_Identity=30.46875, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI78706768, Length=128, Percent_Identity=30.46875, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI78706764, Length=124, Percent_Identity=30.6451612903226, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 18368; Mature: 18368

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METINVLFVCMGNICRSPAAEGILRHFAKKEPDLAFHIESCGMGDWHVGHSPDVRMQEAA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
KSRGIILTSQAQQFQKEFFNRFDYILVADKEVLESLYQHAKSTEQKSKIMFMTEYSQFYQ
HHCCEEEEHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHC
GQEVPDPYYQPGGAFELVLDILEDSCVGLLNHIRVKEEKK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
METINVLFVCMGNICRSPAAEGILRHFAKKEPDLAFHIESCGMGDWHVGHSPDVRMQEAA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
KSRGIILTSQAQQFQKEFFNRFDYILVADKEVLESLYQHAKSTEQKSKIMFMTEYSQFYQ
HHCCEEEEHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHC
GQEVPDPYYQPGGAFELVLDILEDSCVGLLNHIRVKEEKK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]