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The map label for this gene is tmk

Identifier: 46446707

GI number: 46446707

Start: 1281277

End: 1281954

Strand: Reverse

Name: tmk

Synonym: pc1073

Alternate gene names: 46446707

Gene position: 1281954-1281277 (Counterclockwise)

Preceding gene: 46446708

Following gene: 46446706

Centisome position: 53.09

GC content: 37.61

Gene sequence:

>678_bases
ATGCCTTCAACGAAATTTAAGGGGTATTTTATCACAATCGAAGGAGGAGAGGGATCTGGTAAATCGACCCTTCTCAACCA
ATTAGGAGACTATTTTCGGAATAAAGGGTTTGAAGTCATTCAAACACGTGAACCTGGAGGAACAAAGCTTGGTGAATCAA
TTCGACATTTGTTGTTGAATCATGAGGATAGCATCTCTATTGGACACCAAGCAGAATTATTATTATTTTTGGCTGCAAGA
GCTCAACATATTGAAGAGTTAATTCAACCAGCGCTTAAAGCTGGAAAAATTGTGCTTTGTGATCGTTTTAATGATTCTAC
GATTGCTTATCAAGGAGCAGCACGAGGATTAAATGCTAAAAAAATACAAGAGTTTTGCCAACTTGTTTGCGCAGAAATAC
TTCCTAATTGGACATTATTTCTAGATGTGTCTCCAGAGATTGGCTTAGCACGTACTCAAAAAATTCAAAAAGTTCATGCG
CAAATGGGGCAATTAGATCGCATCGAATCCGAAAAAATTGAATTTCACGAACGTGTTCGTCAGGCTTTTTTATCTCTTGT
CCAGCAAGAACCTCAGCGAATATATCGTATTGATGCTAATGAAAGTCAATCAAAAGTTTTACAAAAAGCGCTTGAATTTT
TAGAAGAGCAGTGGTCTGACTCGGAGTTGAAAACTTGA

Upstream 100 bases:

>100_bases
CAATTGAACTTAACGAAAACAACGTTTCTTTTGAATCACCAGAAATTAAAATGTCAGTAAAGCCCAGCTCAGAAGAAATT
ACTGATCAATCGGAATAGAC

Downstream 100 bases:

>100_bases
ACAAATTTCCCTCTTCTTTTTCTTTTCTCGTTGGTAATGATCCTATTAAAATTTATCTGCAAAGAATGCTTATAAAAAAA
GCTATCGGAAATTCTTTACT

Product: putative thymidylate kinase, tmk

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MPSTKFKGYFITIEGGEGSGKSTLLNQLGDYFRNKGFEVIQTREPGGTKLGESIRHLLLNHEDSISIGHQAELLLFLAAR
AQHIEELIQPALKAGKIVLCDRFNDSTIAYQGAARGLNAKKIQEFCQLVCAEILPNWTLFLDVSPEIGLARTQKIQKVHA
QMGQLDRIESEKIEFHERVRQAFLSLVQQEPQRIYRIDANESQSKVLQKALEFLEEQWSDSELKT

Sequences:

>Translated_225_residues
MPSTKFKGYFITIEGGEGSGKSTLLNQLGDYFRNKGFEVIQTREPGGTKLGESIRHLLLNHEDSISIGHQAELLLFLAAR
AQHIEELIQPALKAGKIVLCDRFNDSTIAYQGAARGLNAKKIQEFCQLVCAEILPNWTLFLDVSPEIGLARTQKIQKVHA
QMGQLDRIESEKIEFHERVRQAFLSLVQQEPQRIYRIDANESQSKVLQKALEFLEEQWSDSELKT
>Mature_224_residues
PSTKFKGYFITIEGGEGSGKSTLLNQLGDYFRNKGFEVIQTREPGGTKLGESIRHLLLNHEDSISIGHQAELLLFLAARA
QHIEELIQPALKAGKIVLCDRFNDSTIAYQGAARGLNAKKIQEFCQLVCAEILPNWTLFLDVSPEIGLARTQKIQKVHAQ
MGQLDRIESEKIEFHERVRQAFLSLVQQEPQRIYRIDANESQSKVLQKALEFLEEQWSDSELKT

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=38.8349514563107, Blast_Score=137, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PARUW (Q6MCA2)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008072.1
- ProteinModelPortal:   Q6MCA2
- SMR:   Q6MCA2
- STRING:   Q6MCA2
- GeneID:   2780386
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1073
- NMPDR:   fig|264201.1.peg.1073
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q6MCA2
- ProtClustDB:   CLSK2762310
- BioCyc:   CPRO264201:PC1073-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25495; Mature: 25364

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTKFKGYFITIEGGEGSGKSTLLNQLGDYFRNKGFEVIQTREPGGTKLGESIRHLLLN
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
HEDSISIGHQAELLLFLAARAQHIEELIQPALKAGKIVLCDRFNDSTIAYQGAARGLNAK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECHHHCCCCHH
KIQEFCQLVCAEILPNWTLFLDVSPEIGLARTQKIQKVHAQMGQLDRIESEKIEFHERVR
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAFLSLVQQEPQRIYRIDANESQSKVLQKALEFLEEQWSDSELKT
HHHHHHHHHCHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PSTKFKGYFITIEGGEGSGKSTLLNQLGDYFRNKGFEVIQTREPGGTKLGESIRHLLLN
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
HEDSISIGHQAELLLFLAARAQHIEELIQPALKAGKIVLCDRFNDSTIAYQGAARGLNAK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECHHHCCCCHH
KIQEFCQLVCAEILPNWTLFLDVSPEIGLARTQKIQKVHAQMGQLDRIESEKIEFHERVR
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAFLSLVQQEPQRIYRIDANESQSKVLQKALEFLEEQWSDSELKT
HHHHHHHHHCHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA