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The map label for this gene is menB [H]

Identifier: 46446698

GI number: 46446698

Start: 1265384

End: 1266211

Strand: Reverse

Name: menB [H]

Synonym: pc1064

Alternate gene names: 46446698

Gene position: 1266211-1265384 (Counterclockwise)

Preceding gene: 46446701

Following gene: 46446697

Centisome position: 52.44

GC content: 38.89

Gene sequence:

>828_bases
ATGTTAGCGACAGTAAATTGGGAAAAAGTTAAAACTTATCAGGATATTAGGTTAGAAAAAACAGAAGATGGAATAGCAAA
AATTACTATTAATAGACCTGAGGTGCGAAATGCTTTTCGTCCTGAAACGGTTCAAGAAATGCAAGAAGCTTTTGATATCT
GTCGTAATGACTCAACGATTGGCGTGATTATATTGACGGGAGAAGGGCCTCACGCATTTTGTTCAGGAGGTGATCAAAGA
GTTCGTGCAGAAGAAGGCTACATTGGACAAGACGGTGTTCCACGTTTAAATGTCTTAGACTTGCAAAAACAAATTCGCTC
TTTGCCAAAACCTATCATTGCCATGGTGGCTGGTTATGCAATTGGAGGTGGGCATGTCTTACACATCGTTTGTGATTTAA
CAATTGCAGCAAATAATGCACGTTTTGGGCAAGTTGGGCCAAAAGTTGGATCATTTGACGGTGGATTGGGAAGCAGTTAT
TTAGCTCGTATTGTAGGGCAAAAAAAAGCGCGAGAAATTTGGTATTTATGCCGTCAATATGATGCTAAAGAAGCTTTAGA
AATGGGACTTGTCAACTGTGTTGTCCCTTTAGAGCAGCTTGAAAAAGAGACTTTAAAATGGTGTCGTGAAATTTTACAGC
ATTCTCCCTTAGCTCTTCGTTGTTTAAAAGCTTGTTTGAATGCTGATTGTGATGGACAAGTAGGTCTTCTTGACTTAGCA
GGTAATGCGACCATGCTTTATTACATGACTGAAGAAGCTCAAGAAGGAAAACAAGCATTTTTAGAAAAACGGAAGCCTAA
TTTTAATCAATTTCCTCGGTTACCTTAA

Upstream 100 bases:

>100_bases
TTTGTGTATAAATACATAAAATGATATAGATCTTTTCAATCACAGATAATTCCATAGGAATTGTAATTTCATTTTTAGCA
CTTTAAGGATATGAGGGGAT

Downstream 100 bases:

>100_bases
AAAAGATAAAGGTGTTTCTAATGATTGATCAATTGACAAGGCTAAAGCCATGGATGTTGGCAAGCAGGCCAAGAACTTTA
CCGATTTGTTTAGCGCCTAT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MLATVNWEKVKTYQDIRLEKTEDGIAKITINRPEVRNAFRPETVQEMQEAFDICRNDSTIGVIILTGEGPHAFCSGGDQR
VRAEEGYIGQDGVPRLNVLDLQKQIRSLPKPIIAMVAGYAIGGGHVLHIVCDLTIAANNARFGQVGPKVGSFDGGLGSSY
LARIVGQKKAREIWYLCRQYDAKEALEMGLVNCVVPLEQLEKETLKWCREILQHSPLALRCLKACLNADCDGQVGLLDLA
GNATMLYYMTEEAQEGKQAFLEKRKPNFNQFPRLP

Sequences:

>Translated_275_residues
MLATVNWEKVKTYQDIRLEKTEDGIAKITINRPEVRNAFRPETVQEMQEAFDICRNDSTIGVIILTGEGPHAFCSGGDQR
VRAEEGYIGQDGVPRLNVLDLQKQIRSLPKPIIAMVAGYAIGGGHVLHIVCDLTIAANNARFGQVGPKVGSFDGGLGSSY
LARIVGQKKAREIWYLCRQYDAKEALEMGLVNCVVPLEQLEKETLKWCREILQHSPLALRCLKACLNADCDGQVGLLDLA
GNATMLYYMTEEAQEGKQAFLEKRKPNFNQFPRLP
>Mature_275_residues
MLATVNWEKVKTYQDIRLEKTEDGIAKITINRPEVRNAFRPETVQEMQEAFDICRNDSTIGVIILTGEGPHAFCSGGDQR
VRAEEGYIGQDGVPRLNVLDLQKQIRSLPKPIIAMVAGYAIGGGHVLHIVCDLTIAANNARFGQVGPKVGSFDGGLGSSY
LARIVGQKKAREIWYLCRQYDAKEALEMGLVNCVVPLEQLEKETLKWCREILQHSPLALRCLKACLNADCDGQVGLLDLA
GNATMLYYMTEEAQEGKQAFLEKRKPNFNQFPRLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=31.5573770491803, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=31.6793893129771, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI4502327, Length=272, Percent_Identity=31.25, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI70995211, Length=283, Percent_Identity=28.2685512367491, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI213417737, Length=223, Percent_Identity=25.5605381165919, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI157694516, Length=223, Percent_Identity=25.5605381165919, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4757966, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI51538581, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI25453481, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI51538573, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4757968, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI49355787, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=277, Percent_Identity=70.0361010830325, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=32.2448979591837, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI221142681, Length=259, Percent_Identity=32.046332046332, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=28.4644194756554, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=30.859375, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788682, Length=208, Percent_Identity=25.9615384615385, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=276, Percent_Identity=30.4347826086957, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=32.5471698113208, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=31.7829457364341, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560910, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=213, Percent_Identity=27.2300469483568, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=282, Percent_Identity=27.3049645390071, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=208, Percent_Identity=27.8846153846154, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=25.0950570342205, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129971, Length=265, Percent_Identity=33.9622641509434, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653477, Length=265, Percent_Identity=33.9622641509434, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653139, Length=283, Percent_Identity=30.0353356890459, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922422, Length=258, Percent_Identity=24.8062015503876, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357171, Length=187, Percent_Identity=31.5508021390374, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650670, Length=183, Percent_Identity=30.6010928961749, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30595; Mature: 30595

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLATVNWEKVKTYQDIRLEKTEDGIAKITINRPEVRNAFRPETVQEMQEAFDICRNDSTI
CCCCCCHHHHHHHHHHEEECCCCCEEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCE
GVIILTGEGPHAFCSGGDQRVRAEEGYIGQDGVPRLNVLDLQKQIRSLPKPIIAMVAGYA
EEEEEECCCCCHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
IGGGHVLHIVCDLTIAANNARFGQVGPKVGSFDGGLGSSYLARIVGQKKAREIWYLCRQY
CCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DAKEALEMGLVNCVVPLEQLEKETLKWCREILQHSPLALRCLKACLNADCDGQVGLLDLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEC
GNATMLYYMTEEAQEGKQAFLEKRKPNFNQFPRLP
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLATVNWEKVKTYQDIRLEKTEDGIAKITINRPEVRNAFRPETVQEMQEAFDICRNDSTI
CCCCCCHHHHHHHHHHEEECCCCCEEEEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCE
GVIILTGEGPHAFCSGGDQRVRAEEGYIGQDGVPRLNVLDLQKQIRSLPKPIIAMVAGYA
EEEEEECCCCCHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
IGGGHVLHIVCDLTIAANNARFGQVGPKVGSFDGGLGSSYLARIVGQKKAREIWYLCRQY
CCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DAKEALEMGLVNCVVPLEQLEKETLKWCREILQHSPLALRCLKACLNADCDGQVGLLDLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEC
GNATMLYYMTEEAQEGKQAFLEKRKPNFNQFPRLP
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]