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The map label for this gene is menA [H]

Identifier: 46446697

GI number: 46446697

Start: 1264461

End: 1265363

Strand: Reverse

Name: menA [H]

Synonym: pc1063

Alternate gene names: 46446697

Gene position: 1265363-1264461 (Counterclockwise)

Preceding gene: 46446698

Following gene: 46446696

Centisome position: 52.41

GC content: 37.76

Gene sequence:

>903_bases
ATGATTGATCAATTGACAAGGCTAAAGCCATGGATGTTGGCAAGCAGGCCAAGAACTTTACCGATTTGTTTAGCGCCTAT
CATGGTAGGAACTTTTTTGGCGTTTGCTATTGTGCAGAGAATCGACTGGTTTTTAGCAACTTCCTCATTTTTAAGTGTAC
TATTCTTACAAATTGGAACGAATTTAGTCAATGATGCCCTTGATTTTCCAAAAGGAGCGGATACAAAAGAGCGTTTAGGG
CCGAAAAGAATGACTCAAGCGGGATTACTGTCATTTAAACAAACTTTTAGAGGTGGATTGATATGTTTTGGAGTAGCCAT
CTTGATTGGTACTCCTTTAATGATAACGGGGGGATGGCCCTTTGCCGCTATTTTATTTTTTTCTACTCTGTGTGGTTATC
TTTATACGGGAGGTCCCGTTCCATTAGCTTATTATGGCCTTGGGGAGCTTTTTATTTTTATTTTCTATGGACTCGTTGCC
ATTCCCTCTGCTTTTTATTTGCAAACAAAGTTTGTCAATCAAACAGTATTTATTGGTGCGATTCAAATGGGATTTTTAGC
CATGATTCCTAATGCCGTGAATAACTTAAGAGATAGACAAAGCGATGCGAAAGTTGATAAAAAAACGCTTGCGGTTCGTT
TTGGAACAACATTTGCATGTTGGGAAATTACTTTCTTTGCAATAATTCCTTTCATTGTCGGCATTGCTTGGTGGTTTGTT
AACCAACCTTATTTAACACTATTTCCTTTAGGATCATCGCCCCTCGCTTTTCGATTAATCAAAACAATTTGGGAAACTAA
ACAAGGAACTTCTTATCAAGCTAGTTTTGCGCAAAGTATTTTGTTAATTTTTAGTTTTGGTTTATTGTTGGCCGTAGCTT
GTTTGATGCGTATAGCCGAATGA

Upstream 100 bases:

>100_bases
CTGAAGAAGCTCAAGAAGGAAAACAAGCATTTTTAGAAAAACGGAAGCCTAATTTTAATCAATTTCCTCGGTTACCTTAA
AAAAGATAAAGGTGTTTCTA

Downstream 100 bases:

>100_bases
ACGTTGGAAATAATTTGTATGAAAATTGATTGGATAAGTTCCGAATCAAGAGTTTTTTTAAATCCCAGTTATGGCGTTGA
AAAACAACAACTTTACTTAA

Product: putative 1,4-dihydroxy-2-naphthoate octaprenyltransferase, menA

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIDQLTRLKPWMLASRPRTLPICLAPIMVGTFLAFAIVQRIDWFLATSSFLSVLFLQIGTNLVNDALDFPKGADTKERLG
PKRMTQAGLLSFKQTFRGGLICFGVAILIGTPLMITGGWPFAAILFFSTLCGYLYTGGPVPLAYYGLGELFIFIFYGLVA
IPSAFYLQTKFVNQTVFIGAIQMGFLAMIPNAVNNLRDRQSDAKVDKKTLAVRFGTTFACWEITFFAIIPFIVGIAWWFV
NQPYLTLFPLGSSPLAFRLIKTIWETKQGTSYQASFAQSILLIFSFGLLLAVACLMRIAE

Sequences:

>Translated_300_residues
MIDQLTRLKPWMLASRPRTLPICLAPIMVGTFLAFAIVQRIDWFLATSSFLSVLFLQIGTNLVNDALDFPKGADTKERLG
PKRMTQAGLLSFKQTFRGGLICFGVAILIGTPLMITGGWPFAAILFFSTLCGYLYTGGPVPLAYYGLGELFIFIFYGLVA
IPSAFYLQTKFVNQTVFIGAIQMGFLAMIPNAVNNLRDRQSDAKVDKKTLAVRFGTTFACWEITFFAIIPFIVGIAWWFV
NQPYLTLFPLGSSPLAFRLIKTIWETKQGTSYQASFAQSILLIFSFGLLLAVACLMRIAE
>Mature_300_residues
MIDQLTRLKPWMLASRPRTLPICLAPIMVGTFLAFAIVQRIDWFLATSSFLSVLFLQIGTNLVNDALDFPKGADTKERLG
PKRMTQAGLLSFKQTFRGGLICFGVAILIGTPLMITGGWPFAAILFFSTLCGYLYTGGPVPLAYYGLGELFIFIFYGLVA
IPSAFYLQTKFVNQTVFIGAIQMGFLAMIPNAVNNLRDRQSDAKVDKKTLAVRFGTTFACWEITFFAIIPFIVGIAWWFV
NQPYLTLFPLGSSPLAFRLIKTIWETKQGTSYQASFAQSILLIFSFGLLLAVACLMRIAE

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=299, Percent_Identity=26.4214046822742, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790365, Length=223, Percent_Identity=32.7354260089686, Blast_Score=114, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17737429, Length=299, Percent_Identity=28.0936454849498, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33348; Mature: 33348

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQLTRLKPWMLASRPRTLPICLAPIMVGTFLAFAIVQRIDWFLATSSFLSVLFLQIGT
CCCCHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLVNDALDFPKGADTKERLGPKRMTQAGLLSFKQTFRGGLICFGVAILIGTPLMITGGWP
HHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCH
FAAILFFSTLCGYLYTGGPVPLAYYGLGELFIFIFYGLVAIPSAFYLQTKFVNQTVFIGA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
IQMGFLAMIPNAVNNLRDRQSDAKVDKKTLAVRFGTTFACWEITFFAIIPFIVGIAWWFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
NQPYLTLFPLGSSPLAFRLIKTIWETKQGTSYQASFAQSILLIFSFGLLLAVACLMRIAE
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDQLTRLKPWMLASRPRTLPICLAPIMVGTFLAFAIVQRIDWFLATSSFLSVLFLQIGT
CCCCHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLVNDALDFPKGADTKERLGPKRMTQAGLLSFKQTFRGGLICFGVAILIGTPLMITGGWP
HHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCH
FAAILFFSTLCGYLYTGGPVPLAYYGLGELFIFIFYGLVAIPSAFYLQTKFVNQTVFIGA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
IQMGFLAMIPNAVNNLRDRQSDAKVDKKTLAVRFGTTFACWEITFFAIIPFIVGIAWWFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
NQPYLTLFPLGSSPLAFRLIKTIWETKQGTSYQASFAQSILLIFSFGLLLAVACLMRIAE
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]