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The map label for this gene is ubiE

Identifier: 46446694

GI number: 46446694

Start: 1262125

End: 1262853

Strand: Direct

Name: ubiE

Synonym: pc1060

Alternate gene names: 46446694

Gene position: 1262125-1262853 (Clockwise)

Preceding gene: 46446693

Following gene: 46446695

Centisome position: 52.27

GC content: 37.17

Gene sequence:

>729_bases
ATGTCGACCTACAATAAAAATCGCCCTCAGACGATCCAAATCATGTTTAATAGTATTGCTAAACAGTATGATCGGACAAA
TGCTGTTCTTTCCTTCTGTCTTCATAGACGATGGAATCTAGAACTTGTCAAGAAAGTTCAATCCCAACAAACTTCTCATA
CCTTGCTTGATCTTTGTGCAGGGACAGGAGATGTAGCTTTTAGCTATCTCAACCAAGTTTCAGCCCCTTGTCAAGCCTAT
TTAGTTGATTTTTCTTCTGAAATGTTAGCTTGTGCTGAAGAAAAAGCAAAAAGTTTTGGGAAAACACCTCATTCATTTCA
ATACGTTTTAGCAGATGTTCAGCGCCTTCCTTTTTCGAATCAAACAATGGATTGTGCGACGATGGCTTATGGAATTCGTA
ATATTCACCACCCTCTTCAATCTCTTCAAGAAACTTATCGAGTTTTAAAGCCCGGTGGTTGCCTGGGGATTTTAGAATTA
ACACGACCCGAAAATAAATTTCTTCAAATAGGGCATCAACTTTATTTAAAAACATTACTTCCATTATTAGGAAAATGGCT
AACGGCCAATGAAAATGCTTATCAATATTTAAGAAAAAGCATCCATACTTTCATTCCCCCAGGTGAATTGGAAGAACTTG
TAAAAACAGCGGGATTCATTAATACGGGTCGTTATTCATTAGCAGGAGGTATTGCAACGATCATTACTGGTTTTAAACCC
ATGAAATAA

Upstream 100 bases:

>100_bases
AGGAAAATTTACAAGAAACCTCCGATGAATTAAATAATCCTTTATCCAAACAATAAAAAAATGATTGTTTCCTAGATTTT
TTAAATACGAGGCTATTTTC

Downstream 100 bases:

>100_bases
ACGATATATAAACATATTCCATGTTGAGAAAAGATGCCCTCTGTTAGTTTTAAACAAGAAATTTTCATTCCTTTTCATTA
TGTAGACGCCGCAGGGATTT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSTYNKNRPQTIQIMFNSIAKQYDRTNAVLSFCLHRRWNLELVKKVQSQQTSHTLLDLCAGTGDVAFSYLNQVSAPCQAY
LVDFSSEMLACAEEKAKSFGKTPHSFQYVLADVQRLPFSNQTMDCATMAYGIRNIHHPLQSLQETYRVLKPGGCLGILEL
TRPENKFLQIGHQLYLKTLLPLLGKWLTANENAYQYLRKSIHTFIPPGELEELVKTAGFINTGRYSLAGGIATIITGFKP
MK

Sequences:

>Translated_242_residues
MSTYNKNRPQTIQIMFNSIAKQYDRTNAVLSFCLHRRWNLELVKKVQSQQTSHTLLDLCAGTGDVAFSYLNQVSAPCQAY
LVDFSSEMLACAEEKAKSFGKTPHSFQYVLADVQRLPFSNQTMDCATMAYGIRNIHHPLQSLQETYRVLKPGGCLGILEL
TRPENKFLQIGHQLYLKTLLPLLGKWLTANENAYQYLRKSIHTFIPPGELEELVKTAGFINTGRYSLAGGIATIITGFKP
MK
>Mature_241_residues
STYNKNRPQTIQIMFNSIAKQYDRTNAVLSFCLHRRWNLELVKKVQSQQTSHTLLDLCAGTGDVAFSYLNQVSAPCQAYL
VDFSSEMLACAEEKAKSFGKTPHSFQYVLADVQRLPFSNQTMDCATMAYGIRNIHHPLQSLQETYRVLKPGGCLGILELT
RPENKFLQIGHQLYLKTLLPLLGKWLTANENAYQYLRKSIHTFIPPGELEELVKTAGFINTGRYSLAGGIATIITGFKPM
K

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=258, Percent_Identity=32.9457364341085, Blast_Score=141, Evalue=7e-34,
Organism=Escherichia coli, GI48994983, Length=234, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17557039, Length=236, Percent_Identity=33.8983050847458, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323526, Length=238, Percent_Identity=29.8319327731092, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24641702, Length=244, Percent_Identity=31.9672131147541, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_PARUW (Q6MCB5)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008059.1
- ProteinModelPortal:   Q6MCB5
- STRING:   Q6MCB5
- GeneID:   2779722
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1060
- NMPDR:   fig|264201.1.peg.1060
- eggNOG:   COG2226
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   CPRO264201:PC1060-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27301; Mature: 27170

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure 
STYNKNRPQTIQIMFNSIAKQYDRTNAVLSFCLHRRWNLELVKKVQSQQTSHTLLDLCA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GTGDVAFSYLNQVSAPCQAYLVDFSSEMLACAEEKAKSFGKTPHSFQYVLADVQRLPFSN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
QTMDCATMAYGIRNIHHPLQSLQETYRVLKPGGCLGILELTRPENKFLQIGHQLYLKTLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
PLLGKWLTANENAYQYLRKSIHTFIPPGELEELVKTAGFINTGRYSLAGGIATIITGFKP
HHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
MK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA