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The map label for this gene is umuD [H]

Identifier: 46446610

GI number: 46446610

Start: 1175042

End: 1175473

Strand: Reverse

Name: umuD [H]

Synonym: pc0976

Alternate gene names: 46446610

Gene position: 1175473-1175042 (Counterclockwise)

Preceding gene: 46446611

Following gene: 46446609

Centisome position: 48.68

GC content: 37.04

Gene sequence:

>432_bases
ATGACGTTGATTTTTTTAGAAAATATTTCTTCTGCTGAAAAACAATTTTATCATTTACCCTTTTACCAGCAGACGATTTC
GGCAGGTTTTCCATCTCCAGCTGAAAATGAGATGGCAGATCGCATTGATTTGAATGCTTTGTTAATTAAGCACCCTTCCG
CGACTTTTTTCCTTAAGGTGTCTGGTTCTTCGATGATTAATGCAGGGATTCATCATCAAGATATTTTAGTTGTCGACCGA
AGTTTGCCTGCAGTGGATGGCAAAGTGGTTATTGCGTCTGTTGATGGAGAATTAACGGTAAAAAGATTAAAAATAGCATT
TAAAAAAGTGCAGTTGATAGCTGAAAATGATCAATATCCTTCTATCGAAATTTCCGAAGAGATGAATCTGCATATTTGGG
GGGTTGTGACTCATGTCATTCATGCTGTCTAA

Upstream 100 bases:

>100_bases
CATTAGGGCTTGTTTTAATTAGATTTTCCTATCAGAATTAAAAATAAAACATTTATTTCCTAATCACTAGAATCCTAATA
GTGATTTGAAGGTTAGCCCA

Downstream 100 bases:

>100_bases
TTCTGATTGCGTGGAATCATTATCAAGGGATCAATTCATTTTAGTAGATTGCAATAATTTTTATGTATCCTGTGAAAGAT
TATTCAATCCTAACCTTGAA

Product: SOS mutagenesis and repair protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTLIFLENISSAEKQFYHLPFYQQTISAGFPSPAENEMADRIDLNALLIKHPSATFFLKVSGSSMINAGIHHQDILVVDR
SLPAVDGKVVIASVDGELTVKRLKIAFKKVQLIAENDQYPSIEISEEMNLHIWGVVTHVIHAV

Sequences:

>Translated_143_residues
MTLIFLENISSAEKQFYHLPFYQQTISAGFPSPAENEMADRIDLNALLIKHPSATFFLKVSGSSMINAGIHHQDILVVDR
SLPAVDGKVVIASVDGELTVKRLKIAFKKVQLIAENDQYPSIEISEEMNLHIWGVVTHVIHAV
>Mature_142_residues
TLIFLENISSAEKQFYHLPFYQQTISAGFPSPAENEMADRIDLNALLIKHPSATFFLKVSGSSMINAGIHHQDILVVDRS
LPAVDGKVVIASVDGELTVKRLKIAFKKVQLIAENDQYPSIEISEEMNLHIWGVVTHVIHAV

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=130, Percent_Identity=48.4615384615385, Blast_Score=128, Evalue=1e-31,
Organism=Escherichia coli, GI1790476, Length=117, Percent_Identity=35.8974358974359, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 15910; Mature: 15778

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIFLENISSAEKQFYHLPFYQQTISAGFPSPAENEMADRIDLNALLIKHPSATFFLKV
CEEEEEECCCCCCHHEEECCHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEEE
SGSSMINAGIHHQDILVVDRSLPAVDGKVVIASVDGELTVKRLKIAFKKVQLIAENDQYP
CCCCEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHEEEEECCCCCC
SIEISEEMNLHIWGVVTHVIHAV
CEEECCCCCEEEHHHHHHHHHCC
>Mature Secondary Structure 
TLIFLENISSAEKQFYHLPFYQQTISAGFPSPAENEMADRIDLNALLIKHPSATFFLKV
EEEEEECCCCCCHHEEECCHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCEEEEEE
SGSSMINAGIHHQDILVVDRSLPAVDGKVVIASVDGELTVKRLKIAFKKVQLIAENDQYP
CCCCEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHEEEEECCCCCC
SIEISEEMNLHIWGVVTHVIHAV
CEEECCCCCEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]